BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

361 related articles for article (PubMed ID: 26685860)

  • 1. Identification of novel inhibitors for Pim-1 kinase using pharmacophore modeling based on a novel method for selecting pharmacophore generation subsets.
    Shahin R; Swellmeen L; Shaheen O; Aboalhaija N; Habash M
    J Comput Aided Mol Des; 2016 Jan; 30(1):39-68. PubMed ID: 26685860
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure based drug design of Pim-1 kinase followed by pharmacophore guided synthesis of quinolone-based inhibitors.
    Swellmeen L; Shahin R; Al-Hiari Y; Alamiri A; Hasan A; Shaheen O
    Bioorg Med Chem; 2017 Sep; 25(17):4855-4875. PubMed ID: 28760531
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting Pim-1 kinase for potential drug-development.
    Gadewal N; Varma A
    Int J Comput Biol Drug Des; 2012; 5(2):137-51. PubMed ID: 22854122
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Integrated molecular docking, 3D QSAR and molecular dynamics simulation studies on indole derivatives for designing new Pim-1 inhibitors.
    Peddi SR; Peddi SR; Sivan S; Veerati R; Manga V
    J Recept Signal Transduct Res; 2020 Feb; 40(1):1-14. PubMed ID: 31931654
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Ligand-based computer aided drug design reveals new tropomycin receptor kinase a (TrkA) inhibitors.
    Shahin R; Mansi I; Swellmeen L; Alwidyan T; Al-Hashimi N; Al-Qarar'h Y; Shaheen O
    J Mol Graph Model; 2018 Mar; 80():327-352. PubMed ID: 29454290
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases.
    Casuscelli F; Ardini E; Avanzi N; Casale E; Cervi G; D'Anello M; Donati D; Faiardi D; Ferguson RD; Fogliatto G; Galvani A; Marsiglio A; Mirizzi DG; Montemartini M; Orrenius C; Papeo G; Piutti C; Salom B; Felder ER
    Bioorg Med Chem; 2013 Dec; 21(23):7364-80. PubMed ID: 24139169
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 3D QSAR studies, molecular docking and ADMET evaluation, using thiazolidine derivatives as template to obtain new inhibitors of PIM1 kinase.
    Aouidate A; Ghaleb A; Ghamali M; Ousaa A; Choukrad M; Sbai A; Bouachrine M; Lakhlifi T
    Comput Biol Chem; 2018 Jun; 74():201-211. PubMed ID: 29635214
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Elaborate ligand-based modeling and subsequent synthetic exploration unveil new nanomolar Ca2+/calmodulin-dependent protein kinase II inhibitory leads.
    Shahin R; Taha MO
    Bioorg Med Chem; 2012 Jan; 20(1):377-400. PubMed ID: 22112539
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study.
    Chen Q; Wang Y; Shi S; Li K; Zhang L; Gao J
    Int J Mol Sci; 2019 Oct; 20(21):. PubMed ID: 31671637
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis.
    Al-Sha'er MA; Al-Aqtash RA; Taha MO
    Med Chem; 2019; 15(6):588-601. PubMed ID: 30799792
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of new heat shock protein 90 inhibitors using virtual co-crystallized pharmacophore generation.
    Al-Sha'er MA; Mansi I; Khanfar M; Abudayyh A
    J Enzyme Inhib Med Chem; 2016; 31(sup4):64-77. PubMed ID: 27569779
    [TBL] [Abstract][Full Text] [Related]  

  • 12. QSAR based docking studies of marine algal anticancer compounds as inhibitors of protein kinase B (PKBβ).
    Davis GD; Vasanthi AH
    Eur J Pharm Sci; 2015 Aug; 76():110-8. PubMed ID: 25936945
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery and identification of PIM-1 kinase inhibitors through a hybrid screening approach.
    Shao M; Yuan Y; Yu K; Lei K; Zhu G; Chen L; Xiang M
    Mol Divers; 2014 May; 18(2):335-44. PubMed ID: 24519385
    [TBL] [Abstract][Full Text] [Related]  

  • 14. QSAR-guided pharmacophoric modeling reveals important structural requirements for Polo kinase 1 (Plk1) inhibitors.
    Shahin R; Al-Hashimi NN; Daoud NE; Aljamal S; Shaheen O
    J Mol Graph Model; 2021 Dec; 109():108022. PubMed ID: 34562852
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of novel Pim-1 kinase inhibitors by a hierarchical multistage virtual screening approach based on SVM model, pharmacophore, and molecular docking.
    Ren JX; Li LL; Zheng RL; Xie HZ; Cao ZX; Feng S; Pan YL; Chen X; Wei YQ; Yang SY
    J Chem Inf Model; 2011 Jun; 51(6):1364-75. PubMed ID: 21618971
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification and structure-activity relationship of 8-hydroxy-quinoline-7-carboxylic acid derivatives as inhibitors of Pim-1 kinase.
    Sliman F; Blairvacq M; Durieu E; Meijer L; Rodrigo J; Desmaële D
    Bioorg Med Chem Lett; 2010 May; 20(9):2801-5. PubMed ID: 20363627
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of new MurF inhibitors via pharmacophore modeling and QSAR analysis followed by in-silico screening.
    Taha MO; Atallah N; Al-Bakri AG; Paradis-Bleau C; Zalloum H; Younis KS; Levesque RC
    Bioorg Med Chem; 2008 Feb; 16(3):1218-35. PubMed ID: 17988876
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A crystallographic fragment screen identifies cinnamic acid derivatives as starting points for potent Pim-1 inhibitors.
    Schulz MN; Fanghänel J; Schäfer M; Badock V; Briem H; Boemer U; Nguyen D; Husemann M; Hillig RC
    Acta Crystallogr D Biol Crystallogr; 2011 Mar; 67(Pt 3):156-66. PubMed ID: 21358046
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis.
    Taha MO; Al-Sha'er MA; Khanfar MA; Al-Nadaf AH
    Eur J Med Chem; 2014 Sep; 84():454-65. PubMed ID: 25050878
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase.
    Pierce AC; Jacobs M; Stuver-Moody C
    J Med Chem; 2008 Mar; 51(6):1972-5. PubMed ID: 18290603
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.