BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

186 related articles for article (PubMed ID: 26707936)

  • 1. CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia.
    Jena N; Sheng J; Hu JK; Li W; Zhou W; Lee G; Tsichlis N; Pathak A; Brown N; Deshpande A; Luo C; Hu GF; Hinds PW; Van Etten RA; Hu MG
    Leukemia; 2016 May; 30(5):1033-43. PubMed ID: 26707936
    [TBL] [Abstract][Full Text] [Related]  

  • 2. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.
    Hales EC; Taub JW; Matherly LH
    Cell Signal; 2014 Jan; 26(1):149-61. PubMed ID: 24140475
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
    Rodríguez-Díez E; Quereda V; Bellutti F; Prchal-Murphy M; Partida D; Eguren M; Kollmann K; Gómez de Cedrón M; Dubus P; Cañamero M; Martínez D; Sexl V; Malumbres M
    Blood; 2014 Oct; 124(15):2380-90. PubMed ID: 25157181
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ribociclib, a Cdk4/Cdk6 kinase inhibitor, enhances glucocorticoid sensitivity in B-acute lymphoblastic leukemia (B-All).
    Bortolozzi R; Mattiuzzo E; Trentin L; Accordi B; Basso G; Viola G
    Biochem Pharmacol; 2018 Jul; 153():230-241. PubMed ID: 29408328
    [TBL] [Abstract][Full Text] [Related]  

  • 5. CDK6 kinase activity is required for thymocyte development.
    Hu MG; Deshpande A; Schlichting N; Hinds EA; Mao C; Dose M; Hu GF; Van Etten RA; Gounari F; Hinds PW
    Blood; 2011 Jun; 117(23):6120-31. PubMed ID: 21508411
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.
    Sawai CM; Freund J; Oh P; Ndiaye-Lobry D; Bretz JC; Strikoudis A; Genesca L; Trimarchi T; Kelliher MA; Clark M; Soulier J; Chen-Kiang S; Aifantis I
    Cancer Cell; 2012 Oct; 22(4):452-65. PubMed ID: 23079656
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.
    Wang H; Nicolay BN; Chick JM; Gao X; Geng Y; Ren H; Gao H; Yang G; Williams JA; Suski JM; Keibler MA; Sicinska E; Gerdemann U; Haining WN; Roberts TM; Polyak K; Gygi SP; Dyson NJ; Sicinski P
    Nature; 2017 Jun; 546(7658):426-430. PubMed ID: 28607489
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.
    Fujimoto T; Anderson K; Jacobsen SE; Nishikawa SI; Nerlov C
    EMBO J; 2007 May; 26(9):2361-70. PubMed ID: 17431401
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
    Rao SS; O'Neil J; Liberator CD; Hardwick JS; Dai X; Zhang T; Tyminski E; Yuan J; Kohl NE; Richon VM; Van der Ploeg LH; Carroll PM; Draetta GF; Look AT; Strack PR; Winter CG
    Cancer Res; 2009 Apr; 69(7):3060-8. PubMed ID: 19318552
    [TBL] [Abstract][Full Text] [Related]  

  • 10. KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo.
    Pekkonen P; Järviluoma A; Zinovkina N; Cvrljevic A; Prakash S; Westermarck J; Evan GI; Cesarman E; Verschuren EW; Ojala PM
    Cell Cycle; 2014; 13(23):3670-84. PubMed ID: 25483078
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia.
    Mendes RD; Canté-Barrett K; Pieters R; Meijerink JP
    Haematologica; 2016 Sep; 101(9):1010-7. PubMed ID: 27582570
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.
    Guo D; Ye J; Dai J; Li L; Chen F; Ma D; Ji C
    Leuk Res; 2009 May; 33(5):678-85. PubMed ID: 19091404
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.
    Durinck K; Wallaert A; Van de Walle I; Van Loocke W; Volders PJ; Vanhauwaert S; Geerdens E; Benoit Y; Van Roy N; Poppe B; Soulier J; Cools J; Mestdagh P; Vandesompele J; Rondou P; Van Vlierberghe P; Taghon T; Speleman F
    Haematologica; 2014 Dec; 99(12):1808-16. PubMed ID: 25344525
    [TBL] [Abstract][Full Text] [Related]  

  • 14. IL-7R is essential for leukemia-initiating cell activity of T-cell acute lymphoblastic leukemia.
    González-García S; Mosquera M; Fuentes P; Palumbo T; Escudero A; Pérez-Martínez A; Ramírez M; Corcoran AE; Toribio ML
    Blood; 2019 Dec; 134(24):2171-2182. PubMed ID: 31530562
    [TBL] [Abstract][Full Text] [Related]  

  • 15. β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.
    Gekas C; D'Altri T; Aligué R; González J; Espinosa L; Bigas A
    Leukemia; 2016 Oct; 30(10):2002-2010. PubMed ID: 27125305
    [TBL] [Abstract][Full Text] [Related]  

  • 16. NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.
    Giambra V; Jenkins CR; Wang H; Lam SH; Shevchuk OO; Nemirovsky O; Wai C; Gusscott S; Chiang MY; Aster JC; Humphries RK; Eaves C; Weng AP
    Nat Med; 2012 Nov; 18(11):1693-8. PubMed ID: 23086478
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Selective inhibition of Ph-positive ALL cell growth through kinase-dependent and -independent effects by CDK6-specific PROTACs.
    De Dominici M; Porazzi P; Xiao Y; Chao A; Tang HY; Kumar G; Fortina P; Spinelli O; Rambaldi A; Peterson LF; Petruk S; Barletta C; Mazo A; Cingolani G; Salvino JM; Calabretta B
    Blood; 2020 Apr; 135(18):1560-1573. PubMed ID: 32040545
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity.
    Yang C; Boyson CA; Di Liberto M; Huang X; Hannah J; Dorn DC; Moore MA; Chen-Kiang S; Zhou P
    Cancer Res; 2015 May; 75(9):1838-45. PubMed ID: 25744718
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Murine Pten(-/-) T-ALL requires non-redundant PI3K/mTOR and DLL4/Notch1 signals for maintenance and γc/TCR signals for thymic exit.
    Hagenbeek TJ; Wu X; Choy L; Sanchez-Irizarry C; Seshagiri S; Stinson J; Siebel CW; Spits H
    Cancer Lett; 2014 May; 346(2):237-48. PubMed ID: 24384093
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of Notch1 promotes development of human CD8(+) single positive T cells in humanized mice.
    Haji Y; Suzuki M; Moriya K; So T; Hozumi K; Mizuma M; Unno M; Ishii N
    Biochem Biophys Res Commun; 2014 May; 447(2):346-51. PubMed ID: 24726647
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.