175 related articles for article (PubMed ID: 26714710)
1. Methods for the Analyses of Inhibitor-Induced Aberrant Multimerization of HIV-1 Integrase.
Kessl JJ; Sharma A; Kvaratskhelia M
Methods Mol Biol; 2016; 1354():149-64. PubMed ID: 26714710
[TBL] [Abstract][Full Text] [Related]
2. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Feng L; Dharmarajan V; Serrao E; Hoyte A; Larue RC; Slaughter A; Sharma A; Plumb MR; Kessl JJ; Fuchs JR; Bushman FD; Engelman AN; Griffin PR; Kvaratskhelia M
ACS Chem Biol; 2016 May; 11(5):1313-21. PubMed ID: 26910179
[TBL] [Abstract][Full Text] [Related]
3. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L; Sharma A; Slaughter A; Jena N; Koh Y; Shkriabai N; Larue RC; Patel PA; Mitsuya H; Kessl JJ; Engelman A; Fuchs JR; Kvaratskhelia M
J Biol Chem; 2013 May; 288(22):15813-20. PubMed ID: 23615903
[TBL] [Abstract][Full Text] [Related]
4. A new class of multimerization selective inhibitors of HIV-1 integrase.
Sharma A; Slaughter A; Jena N; Feng L; Kessl JJ; Fadel HJ; Malani N; Male F; Wu L; Poeschla E; Bushman FD; Fuchs JR; Kvaratskhelia M
PLoS Pathog; 2014 May; 10(5):e1004171. PubMed ID: 24874515
[TBL] [Abstract][Full Text] [Related]
5. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
Patel D; Antwi J; Koneru PC; Serrao E; Forli S; Kessl JJ; Feng L; Deng N; Levy RM; Fuchs JR; Olson AJ; Engelman AN; Bauman JD; Kvaratskhelia M; Arnold E
J Biol Chem; 2016 Nov; 291(45):23569-23577. PubMed ID: 27645997
[TBL] [Abstract][Full Text] [Related]
6. A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.
Shkriabai N; Dharmarajan V; Slaughter A; Kessl JJ; Larue RC; Feng L; Fuchs JR; Griffin PR; Kvaratskhelia M
J Biol Chem; 2014 Sep; 289(38):26430-26440. PubMed ID: 25118283
[TBL] [Abstract][Full Text] [Related]
7. A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor.
Nakamura T; Nakamura T; Amano M; Miyakawa T; Yamagata Y; Matsuoka M; Nakata H
J Virol; 2020 Sep; 94(19):. PubMed ID: 32611758
[TBL] [Abstract][Full Text] [Related]
8. Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer.
Sun J; Patel K; Hume J; Pigza JA; Donahue MG; Kessl JJ
J Biol Chem; 2021; 296():100363. PubMed ID: 33539919
[TBL] [Abstract][Full Text] [Related]
9. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors.
Koneru PC; Francis AC; Deng N; Rebensburg SV; Hoyte AC; Lindenberger J; Adu-Ampratwum D; Larue RC; Wempe MF; Engelman AN; Lyumkis D; Fuchs JR; Levy RM; Melikyan GB; Kvaratskhelia M
Elife; 2019 May; 8():. PubMed ID: 31120420
[TBL] [Abstract][Full Text] [Related]
10. Allosteric inhibition of HIV-1 integrase activity.
Engelman A; Kessl JJ; Kvaratskhelia M
Curr Opin Chem Biol; 2013 Jun; 17(3):339-45. PubMed ID: 23647983
[TBL] [Abstract][Full Text] [Related]
11. HIV-1 integrase multimerization as a therapeutic target.
Feng L; Larue RC; Slaughter A; Kessl JJ; Kvaratskhelia M
Curr Top Microbiol Immunol; 2015; 389():93-119. PubMed ID: 25778682
[TBL] [Abstract][Full Text] [Related]
12. Discovery of a Distinct Chemical and Mechanistic Class of Allosteric HIV-1 Integrase Inhibitors with Antiretroviral Activity.
Burlein C; Wang C; Xu M; Bhatt T; Stahlhut M; Ou Y; Adam GC; Heath J; Klein DJ; Sanders J; Narayan K; Abeywickrema P; Heo MR; Carroll SS; Grobler JA; Sharma S; Diamond TL; Converso A; Krosky DJ
ACS Chem Biol; 2017 Nov; 12(11):2858-2865. PubMed ID: 29024587
[TBL] [Abstract][Full Text] [Related]
13. Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors.
Sun J; Kessl JJ
Viruses; 2024 Jan; 16(2):. PubMed ID: 38399977
[TBL] [Abstract][Full Text] [Related]
14. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Jurado KA; Wang H; Slaughter A; Feng L; Kessl JJ; Koh Y; Wang W; Ballandras-Colas A; Patel PA; Fuchs JR; Kvaratskhelia M; Engelman A
Proc Natl Acad Sci U S A; 2013 May; 110(21):8690-5. PubMed ID: 23610442
[TBL] [Abstract][Full Text] [Related]
15. The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.
Christ F; Debyser Z
Virology; 2013 Jan; 435(1):102-9. PubMed ID: 23217620
[TBL] [Abstract][Full Text] [Related]
16. Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors.
Demeulemeester J; Tintori C; Botta M; Debyser Z; Christ F
J Biomol Screen; 2012 Jun; 17(5):618-28. PubMed ID: 22337657
[TBL] [Abstract][Full Text] [Related]
17. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies.
Deng N; Hoyte A; Mansour YE; Mohamed MS; Fuchs JR; Engelman AN; Kvaratskhelia M; Levy R
Protein Sci; 2016 Nov; 25(11):1911-1917. PubMed ID: 27503276
[TBL] [Abstract][Full Text] [Related]
18. Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors.
Jurado KA; Engelman A
Expert Rev Mol Med; 2013 Nov; 15():e14. PubMed ID: 24274067
[TBL] [Abstract][Full Text] [Related]
19. Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
Bonnard D; Le Rouzic E; Eiler S; Amadori C; Orlov I; Bruneau JM; Brias J; Barbion J; Chevreuil F; Spehner D; Chasset S; Ledoussal B; Moreau F; Saïb A; Klaholz BP; Emiliani S; Ruff M; Zamborlini A; Benarous R
J Biol Chem; 2018 Apr; 293(16):6172-6186. PubMed ID: 29507092
[TBL] [Abstract][Full Text] [Related]
20. Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction.
Zhang FH; Debnath B; Xu ZL; Yang LM; Song LR; Zheng YT; Neamati N; Long YQ
Eur J Med Chem; 2017 Jan; 125():1051-1063. PubMed ID: 27810592
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
