BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1103 related articles for article (PubMed ID: 26718876)

  • 1. In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries.
    Utkarsh D; Loretz C; Li AP
    Chem Biol Interact; 2016 Aug; 255():12-22. PubMed ID: 26718876
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles.
    Zhang J; Doshi U; Suzuki A; Chang CW; Borlak J; Li AP; Tong W
    Chem Biol Interact; 2016 Aug; 255():3-11. PubMed ID: 26581450
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential.
    Li AP; Lu C; Brent JA; Pham C; Fackett A; Ruegg CE; Silber PM
    Chem Biol Interact; 1999 Jun; 121(1):17-35. PubMed ID: 10418968
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts.
    Donato MT; Lahoz A; Jiménez N; Pérez G; Serralta A; Mir J; Castell JV; Gómez-Lechón MJ
    Drug Metab Dispos; 2006 Sep; 34(9):1556-62. PubMed ID: 16763015
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Prediction of Drug-Induced Liver Injury in HepG2 Cells Cultured with Human Liver Microsomes.
    Choi JM; Oh SJ; Lee JY; Jeon JS; Ryu CS; Kim YM; Lee K; Kim SK
    Chem Res Toxicol; 2015 May; 28(5):872-85. PubMed ID: 25860621
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results with Acetaminophen, Amiodarone, Cyclophosphamide, Ketoconazole, Nefazodone, and Troglitazone.
    Wei H; Li AP
    Drug Metab Dispos; 2022 Feb; 50(2):140-149. PubMed ID: 34750194
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI).
    Miyata S; Saku N; Akiyama S; Javaregowda PK; Ite K; Takashima N; Toyoda M; Yura K; Kimura T; Nishina H; Nakazawa A; Kasahara M; Nonaka H; Kiyono T; Umezawa A
    Stem Cell Res Ther; 2022 Jan; 13(1):6. PubMed ID: 35012658
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells.
    Wu Y; Chitranshi P; Loukotková L; Gamboa da Costa G; Beland FA; Zhang J; Fang JL
    Arch Toxicol; 2017 Jun; 91(6):2405-2423. PubMed ID: 27896399
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Prediction of drug-induced immune-mediated hepatotoxicity using hepatocyte-like cells derived from human embryonic stem cells.
    Kim DE; Jang MJ; Kim YR; Lee JY; Cho EB; Kim E; Kim Y; Kim MY; Jeong WI; Kim S; Han YM; Lee SH
    Toxicology; 2017 Jul; 387():1-9. PubMed ID: 28645575
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures.
    Yokoyama Y; Sasaki Y; Terasaki N; Kawataki T; Takekawa K; Iwase Y; Shimizu T; Sanoh S; Ohta S
    Biol Pharm Bull; 2018 May; 41(5):722-732. PubMed ID: 29445054
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse.
    Zhang J; He K; Cai L; Chen YC; Yang Y; Shi Q; Woolf TF; Ge W; Guo L; Borlak J; Tong W
    Chem Biol Interact; 2016 Aug; 255():45-54. PubMed ID: 27000539
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vitro oxidative metabolism of cajaninstilbene Acid by human liver microsomes and hepatocytes: involvement of cytochrome p450 reaction phenotyping, inhibition, and induction studies.
    Hua X; Peng X; Tan S; Li C; Wang W; Luo M; Fu Y; Zu Y; Smyth H
    J Agric Food Chem; 2014 Oct; 62(43):10604-14. PubMed ID: 25272989
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1.
    Li AP
    Chem Biol Interact; 2009 Apr; 179(1):4-8. PubMed ID: 18950609
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 4-Fluoromethamphetamine (4-FMA) induces in vitro hepatotoxicity mediated by CYP2E1, CYP2D6, and CYP3A4 metabolism.
    Roque Bravo R; Carmo H; Valente MJ; Silva JP; Carvalho F; Bastos ML; Dias da Silva D
    Toxicology; 2021 Nov; 463():152988. PubMed ID: 34655687
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes.
    Parkinson A; Mudra DR; Johnson C; Dwyer A; Carroll KM
    Toxicol Appl Pharmacol; 2004 Sep; 199(3):193-209. PubMed ID: 15364537
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.
    Tolosa L; Gómez-Lechón MJ; López S; Guzmán C; Castell JV; Donato MT; Jover R
    Toxicol Sci; 2016 Jul; 152(1):214-29. PubMed ID: 27208088
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.
    Shi Q; Greenhaw J; Salminen WF
    J Appl Toxicol; 2014 Aug; 34(8):835-40. PubMed ID: 23686521
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Liver grafts preserved in Celsior solution as source of hepatocytes for drug metabolism studies: comparison with surgical liver biopsies.
    Donato MT; Serralta A; Jiménez N; Pérez G; Castell JV; Mir J; Gómez-Lechón MJ
    Drug Metab Dispos; 2005 Jan; 33(1):108-14. PubMed ID: 15448115
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.
    Xu S; Liu J; Shi J; Wang Z; Ji L
    Sci Rep; 2017 Nov; 7(1):16511. PubMed ID: 29184146
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of CYP3A in ethanol-mediated increases in acetaminophen hepatotoxicity.
    Kostrubsky VE; Szakacs JG; Jeffery EH; Wood SG; Bement WJ; Wrighton SA; Sinclair PR; Sinclair JF
    Toxicol Appl Pharmacol; 1997 Apr; 143(2):315-23. PubMed ID: 9144448
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 56.