218 related articles for article (PubMed ID: 26723888)
21. Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling.
Du Y; Days E; Romaine I; Abney KK; Kaufmann K; Sulikowski G; Stauffer S; Lindsley CW; Weaver CD
ACS Chem Neurosci; 2015 Jun; 6(6):871-8. PubMed ID: 25879403
[TBL] [Abstract][Full Text] [Related]
22. Using automated patch clamp electrophysiology platforms in ion channel drug discovery: an industry perspective.
Rogers M; Obergrussberger A; Kondratskyi A; Fertig N
Expert Opin Drug Discov; 2024 May; 19(5):523-535. PubMed ID: 38481119
[TBL] [Abstract][Full Text] [Related]
23. A painstaking overhaul for cardiac safety testing.
Servick K
Science; 2016 Sep; 353(6303):976-977. PubMed ID: 27701095
[No Abstract] [Full Text] [Related]
24. Nonradioactive rubidium ion efflux assay and its applications in drug discovery and development.
Terstappen GC
Assay Drug Dev Technol; 2004 Oct; 2(5):553-9. PubMed ID: 15671653
[TBL] [Abstract][Full Text] [Related]
25. Screening technologies for ion channel drug discovery.
Terstappen GC; Roncarati R; Dunlop J; Peri R
Future Med Chem; 2010 May; 2(5):715-30. PubMed ID: 21426199
[TBL] [Abstract][Full Text] [Related]
26. Protein kinase profiling assays: a technology review.
Wang Y; Ma H
Drug Discov Today Technol; 2015 Nov; 18():1-8. PubMed ID: 26723886
[TBL] [Abstract][Full Text] [Related]
27. Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening?
Towart R; Linders JT; Hermans AN; Rohrbacher J; van der Linde HJ; Ercken M; Cik M; Roevens P; Teisman A; Gallacher DJ
J Pharmacol Toxicol Methods; 2009; 60(1):1-10. PubMed ID: 19439185
[TBL] [Abstract][Full Text] [Related]
28. Flux assays in high throughput screening of ion channels in drug discovery.
Gill S; Gill R; Lee SS; Hesketh JC; Fedida D; Rezazadeh S; Stankovich L; Liang D
Assay Drug Dev Technol; 2003 Oct; 1(5):709-17. PubMed ID: 15090243
[TBL] [Abstract][Full Text] [Related]
29. Population patch clamp electrophysiology: a breakthrough technology for ion channel screening.
Dale TJ; Townsend C; Hollands EC; Trezise DJ
Mol Biosyst; 2007 Oct; 3(10):714-22. PubMed ID: 17882333
[TBL] [Abstract][Full Text] [Related]
30. HTS assays for developing the molecular pharmacology of ion channels.
McManus OB
Curr Opin Pharmacol; 2014 Apr; 15():91-6. PubMed ID: 24556186
[TBL] [Abstract][Full Text] [Related]
31. QPatch: the missing link between HTS and ion channel drug discovery.
Mathes C; Friis S; Finley M; Liu Y
Comb Chem High Throughput Screen; 2009 Jan; 12(1):78-95. PubMed ID: 19149494
[TBL] [Abstract][Full Text] [Related]
32. Renaissance of ion channel research and drug discovery by patch clamp automation.
Fertig N; Farre C
Future Med Chem; 2010 May; 2(5):691-5. PubMed ID: 21426196
[No Abstract] [Full Text] [Related]
33. Emerging trends in ion channel-based assays for predicting the cardiac safety of drugs.
Witchel HJ
IDrugs; 2010 Feb; 13(2):90-6. PubMed ID: 20127560
[TBL] [Abstract][Full Text] [Related]
34. High-throughput cardiac safety evaluation and multi-parameter arrhythmia profiling of cardiomyocytes using microelectrode arrays.
Gilchrist KH; Lewis GF; Gay EA; Sellgren KL; Grego S
Toxicol Appl Pharmacol; 2015 Oct; 288(2):249-57. PubMed ID: 26232523
[TBL] [Abstract][Full Text] [Related]
35. Effects of the venom of the spider Ornithoctonus hainana on neonatal rat ventricular myocytes cellular and ionic electrophysiology.
Zhang Y; Liu J; Liu Z; Wang M; Wang J; Lu S; Zhu L; Zeng X; Liang S
Toxicon; 2014 Sep; 87():104-12. PubMed ID: 24930961
[TBL] [Abstract][Full Text] [Related]
36. Human stem cell-derived cardiomyocytes detect drug-mediated changes in action potentials and ion currents.
Gibson JK; Yue Y; Bronson J; Palmer C; Numann R
J Pharmacol Toxicol Methods; 2014; 70(3):255-67. PubMed ID: 25219538
[TBL] [Abstract][Full Text] [Related]
37. Ion channels as medicinal targets of biological toxins: the impact of automated patch-clamp electrophysiology.
Picones A
Curr Top Med Chem; 2015; 15(7):631-7. PubMed ID: 25751269
[TBL] [Abstract][Full Text] [Related]
38. Pharmacogenetics and cardiac ion channels.
Roepke TK; Abbott GW
Vascul Pharmacol; 2006 Feb; 44(2):90-106. PubMed ID: 16344000
[TBL] [Abstract][Full Text] [Related]
39. An ion channel library for drug discovery and safety screening on automated platforms.
Wible BA; Kuryshev YA; Smith SS; Liu Z; Brown AM
Assay Drug Dev Technol; 2008 Dec; 6(6):765-80. PubMed ID: 19090691
[TBL] [Abstract][Full Text] [Related]
40. The future of drug discovery: enabling technologies for enhancing lead characterization and profiling therapeutic potential.
Janero DR
Expert Opin Drug Discov; 2014 Aug; 9(8):847-58. PubMed ID: 24965547
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
