These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

116 related articles for article (PubMed ID: 26725591)

  • 1. Applications of Receptor- and Ligand-based Models in Inverse Docking Experiments: Recognition of Dihydrofolate Reductase Using 7,8-Dialkyl- 1,3-Diaminopyrrolo[3,2-f]Quinazolines.
    Kumar SP; Jasrai YT; Pandya HA
    Curr Comput Aided Drug Des; 2016; 12(1):15-28. PubMed ID: 26725591
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Selectivity analysis of 5-(arylthio)-2,4-diaminoquinazolines as inhibitors of Candida albicans dihydrofolate reductase by molecular dynamics simulations.
    Gokhale VM; Kulkarni VM
    J Comput Aided Mol Des; 2000 Jul; 14(5):495-506. PubMed ID: 10896321
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity.
    Paulsen JL; Bendel SD; Anderson AC
    Chem Biol Drug Des; 2011 Oct; 78(4):505-12. PubMed ID: 21726415
    [TBL] [Abstract][Full Text] [Related]  

  • 4. High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
    Kuyper LF; Baccanari DP; Jones ML; Hunter RN; Tansik RL; Joyner SS; Boytos CM; Rudolph SK; Knick V; Wilson HR; Caddell JM; Friedman HS; Comley JC; Stables JN
    J Med Chem; 1996 Feb; 39(4):892-903. PubMed ID: 8632413
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen
    DeJarnette C; Luna-Tapia A; Estredge LR; Palmer GE
    mSphere; 2020 Jun; 5(3):. PubMed ID: 32581079
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Scoring ensembles of docked protein:ligand interactions for virtual lead optimization.
    Paulsen JL; Anderson AC
    J Chem Inf Model; 2009 Dec; 49(12):2813-9. PubMed ID: 19950979
    [TBL] [Abstract][Full Text] [Related]  

  • 7. In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.
    Paulsen JL; Liu J; Bolstad DB; Smith AE; Priestley ND; Wright DL; Anderson AC
    Bioorg Med Chem; 2009 Jul; 17(14):4866-72. PubMed ID: 19560363
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity.
    Ng HL; Chen S; Chew EH; Chui WK
    Eur J Med Chem; 2016 Jun; 115():63-74. PubMed ID: 26994844
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Deep-learning based repurposing of FDA-approved drugs against
    Joshi T; Pundir H; Chandra S
    J Biomol Struct Dyn; 2022 Nov; 40(18):8420-8436. PubMed ID: 33879017
    [No Abstract]   [Full Text] [Related]  

  • 10. X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor.
    Whitlow M; Howard AJ; Stewart D; Hardman KD; Chan JH; Baccanari DP; Tansik RL; Hong JS; Kuyper LF
    J Med Chem; 2001 Aug; 44(18):2928-32. PubMed ID: 11520201
    [TBL] [Abstract][Full Text] [Related]  

  • 11. pROC-Chemotype Plots Enhance the Interpretability of Benchmarking Results in Structure-Based Virtual Screening.
    Ibrahim TM; Bauer MR; Dörr A; Veyisoglu E; Boeckler FM
    J Chem Inf Model; 2015 Nov; 55(11):2297-307. PubMed ID: 26434782
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis and evaluation of antitumor acylated monoaminopyrroloquinazolines.
    Chao B; Li BX; Xiao X
    Bioorg Med Chem Lett; 2017 Jul; 27(14):3107-3110. PubMed ID: 28552339
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Towards understanding the mechanisms of molecular recognition by computer simulations of ligand-protein interactions.
    Verkhivker GM; Rejto PA; Bouzida D; Arthurs S; Colson AB; Freer ST; Gehlhaar DK; Larson V; Luty BA; Marrone T; Rose PW
    J Mol Recognit; 1999; 12(6):371-89. PubMed ID: 10611647
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
    Schormann N; Senkovich O; Walker K; Wright DL; Anderson AC; Rosowsky A; Ananthan S; Shinkre B; Velu S; Chattopadhyay D
    Proteins; 2008 Dec; 73(4):889-901. PubMed ID: 18536013
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model.
    Graffner-Nordberg M; Fyfe M; Brattsand R; Mellgård B; Hallberg A
    J Med Chem; 2003 Jul; 46(16):3455-62. PubMed ID: 12877583
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3H)-one as DHFR inhibitors.
    El-Gazzar YI; Georgey HH; El-Messery SM; Ewida HA; Hassan GS; Raafat MM; Ewida MA; El-Subbagh HI
    Bioorg Chem; 2017 Jun; 72():282-292. PubMed ID: 28499189
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analysis of Coxiela burnetti dihydrofolate reductase via in silico docking with inhibitors and molecular dynamics simulation.
    de Souza FR; Guimarães AP; Cuya T; de Freitas MP; Gonçalves ADS; Forgione P; Costa França TC
    J Biomol Struct Dyn; 2017 Oct; 35(13):2975-2986. PubMed ID: 27726597
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines.
    Chan JH; Hong JS; Kuyper LF; Baccanari DP; Joyner SS; Tansik RL; Boytos CM; Rudolph SK
    J Med Chem; 1995 Sep; 38(18):3608-16. PubMed ID: 7658448
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.
    Bolstad DB; Bolstad ES; Frey KM; Wright DL; Anderson AC
    J Med Chem; 2008 Nov; 51(21):6839-52. PubMed ID: 18834108
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rational modification of the lead molecule: Enhancement in the anticancer and dihydrofolate reductase inhibitory activity.
    Kaur J; Kaur S; Singh P
    Bioorg Med Chem Lett; 2016 Apr; 26(8):1936-40. PubMed ID: 26979156
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.