These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

283 related articles for article (PubMed ID: 26747608)

  • 1. Mechanistic Insights into Hsp104 Potentiation.
    Torrente MP; Chuang E; Noll MM; Jackrel ME; Go MS; Shorter J
    J Biol Chem; 2016 Mar; 291(10):5101-15. PubMed ID: 26747608
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity.
    Tariq A; Lin J; Jackrel ME; Hesketh CD; Carman PJ; Mack KL; Weitzman R; Gambogi C; Hernandez Murillo OA; Sweeny EA; Gurpinar E; Yokom AL; Gates SN; Yee K; Sudesh S; Stillman J; Rizo AN; Southworth DR; Shorter J
    Cell Rep; 2019 Aug; 28(8):2080-2095.e6. PubMed ID: 31433984
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural and mechanistic insights into Hsp104 function revealed by synchrotron X-ray footprinting.
    Sweeny EA; Tariq A; Gurpinar E; Go MS; Sochor MA; Kan ZY; Mayne L; Englander SW; Shorter J
    J Biol Chem; 2020 Feb; 295(6):1517-1538. PubMed ID: 31882541
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain.
    Ryan JJ; Bao A; Bell B; Ling C; Jackrel ME
    Protein Sci; 2021 Aug; 30(8):1667-1685. PubMed ID: 34010483
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.
    Jackrel ME; Yee K; Tariq A; Chen AI; Shorter J
    ACS Chem Biol; 2015 Dec; 10(12):2672-9. PubMed ID: 26441009
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain.
    Tariq A; Lin J; Noll MM; Torrente MP; Mack KL; Murillo OH; Jackrel ME; Shorter J
    FEMS Yeast Res; 2018 Aug; 18(5):. PubMed ID: 29788207
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.
    Jackrel ME; DeSantis ME; Martinez BA; Castellano LM; Stewart RM; Caldwell KA; Caldwell GA; Shorter J
    Cell; 2014 Jan; 156(1-2):170-82. PubMed ID: 24439375
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding.
    Hattendorf DA; Lindquist SL
    Proc Natl Acad Sci U S A; 2002 Mar; 99(5):2732-7. PubMed ID: 11867765
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants.
    Hattendorf DA; Lindquist SL
    EMBO J; 2002 Jan; 21(1-2):12-21. PubMed ID: 11782421
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.
    Jackrel ME; Shorter J
    Dis Model Mech; 2014 Oct; 7(10):1175-84. PubMed ID: 25062688
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional analysis of proposed substrate-binding residues of Hsp104.
    Howard MK; Sohn BS; von Borcke J; Xu A; Jackrel ME
    PLoS One; 2020; 15(3):e0230198. PubMed ID: 32155221
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Therapeutic genetic variation revealed in diverse Hsp104 homologs.
    March ZM; Sweeney K; Kim H; Yan X; Castellano LM; Jackrel ME; Lin J; Chuang E; Gomes E; Willicott CW; Michalska K; Jedrzejczak RP; Joachimiak A; Caldwell KA; Caldwell GA; Shalem O; Shorter J
    Elife; 2020 Dec; 9():. PubMed ID: 33319748
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulatory circuits of the AAA+ disaggregase Hsp104.
    Franzmann TM; Czekalla A; Walter SG
    J Biol Chem; 2011 May; 286(20):17992-8001. PubMed ID: 21454552
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation.
    Sweeny EA; Jackrel ME; Go MS; Sochor MA; Razzo BM; DeSantis ME; Gupta K; Shorter J
    Mol Cell; 2015 Mar; 57(5):836-849. PubMed ID: 25620563
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.
    Desantis ME; Sweeny EA; Snead D; Leung EH; Go MS; Gupta K; Wendler P; Shorter J
    J Biol Chem; 2014 Jan; 289(2):848-67. PubMed ID: 24280225
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Tuning Hsp104 specificity to selectively detoxify α-synuclein.
    Mack KL; Kim H; Barbieri EM; Lin J; Braganza S; Jackrel ME; DeNizio JE; Yan X; Chuang E; Tariq A; Cupo RR; Castellano LM; Caldwell KA; Caldwell GA; Shorter J
    Mol Cell; 2023 Sep; 83(18):3314-3332.e9. PubMed ID: 37625404
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Isolating potentiated Hsp104 variants using yeast proteinopathy models.
    Jackrel ME; Tariq A; Yee K; Weitzman R; Shorter J
    J Vis Exp; 2014 Nov; (93):e52089. PubMed ID: 25407485
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Engineering therapeutic protein disaggregases.
    Shorter J
    Mol Biol Cell; 2016 May; 27(10):1556-60. PubMed ID: 27255695
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Processing of proteins by the molecular chaperone Hsp104.
    Schaupp A; Marcinowski M; Grimminger V; Bösl B; Walter S
    J Mol Biol; 2007 Jul; 370(4):674-86. PubMed ID: 17543332
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Engineering enhanced protein disaggregases for neurodegenerative disease.
    Jackrel ME; Shorter J
    Prion; 2015; 9(2):90-109. PubMed ID: 25738979
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.