BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

286 related articles for article (PubMed ID: 26748875)

  • 1. Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.
    Mehta AY; Mohammed BM; Martin EJ; Brophy DF; Gailani D; Desai UR
    J Thromb Haemost; 2016 Apr; 14(4):828-38. PubMed ID: 26748875
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects.
    Mehta AY; Thakkar JN; Mohammed BM; Martin EJ; Brophy DF; Kishimoto T; Desai UR
    J Med Chem; 2014 Apr; 57(7):3030-9. PubMed ID: 24635452
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.
    Mehta AY; Desai UR
    Biochem Biophys Res Commun; 2014 Sep; 452(3):813-6. PubMed ID: 25201728
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis.
    Lei X; Reheman A; Hou Y; Zhou H; Wang Y; Marshall AH; Liang C; Dai X; Li BX; Vanhoorelbeke K; Ni H
    Thromb Haemost; 2014 Feb; 111(2):279-89. PubMed ID: 24172860
    [TBL] [Abstract][Full Text] [Related]  

  • 5. WY-14643, a novel antiplatelet and antithrombotic agent targeting the GPIbα receptor.
    Cao C; Yang Q; Xia X; Chen Z; Liu P; Wu X; Hu H; Ding Z; Li X
    Thromb Res; 2024 Jun; 238():41-51. PubMed ID: 38669962
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha.
    Celikel R; McClintock RA; Roberts JR; Mendolicchio GL; Ware J; Varughese KI; Ruggeri ZM
    Science; 2003 Jul; 301(5630):218-21. PubMed ID: 12855810
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.
    Zarpellon A; Celikel R; Roberts JR; McClintock RA; Mendolicchio GL; Moore KL; Jing H; Varughese KI; Ruggeri ZM
    Proc Natl Acad Sci U S A; 2011 May; 108(21):8628-33. PubMed ID: 21555542
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Global Thrombosis Test (GTT) can detect major determinants of haemostasis including platelet reactivity, endogenous fibrinolytic and thrombin generating potential.
    Yamamoto J; Inoue N; Otsui K; Ishii H; Gorog DA
    Thromb Res; 2014 May; 133(5):919-26. PubMed ID: 24613697
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Anti-thrombotic Effects Mediated by a Novel Dual-Target Peptide Inhibiting Both Platelet Aggregation and Thrombin Activity without Causing Bleeding.
    Yu J; Wang T; Zhang X; Chen Q; Hu Y; Liang Q; Shi Y; Wang Y; Zhang Y; Yu M; Zhao B
    Thromb Haemost; 2024 Feb; 124(2):108-121. PubMed ID: 37657484
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A critical role for thrombin in platelet aggregation under high shear stress.
    Sakurai Y; Shima M; Giddings J; Takeyama M; Kasuda S; Nogami K; Nishiya K; Yoshioka A
    Thromb Res; 2004; 113(5):311-8. PubMed ID: 15183043
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Intravenously administered APAC, a dual AntiPlatelet AntiCoagulant, targets arterial injury site to inhibit platelet thrombus formation and tissue factor activity in mice.
    Bonetti NR; Jouppila AS; Saeedi Saravi SS; Cooley BC; Pasterk L; Liberale LL; Gobbato S; Lüscher TF; Camici GG; Lassila RP; Beer JH
    Thromb Res; 2023 Aug; 228():163-171. PubMed ID: 37331119
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation.
    Dumas JJ; Kumar R; Seehra J; Somers WS; Mosyak L
    Science; 2003 Jul; 301(5630):222-6. PubMed ID: 12855811
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Comparison of thrombin active site and exosite inhibitors and heparin in experimental models of arterial and venous thrombosis and bleeding.
    Schumacher WA; Steinbacher TE; Heran CL; Seiler SM; Michel IM; Ogletree ML
    J Pharmacol Exp Ther; 1993 Dec; 267(3):1237-42. PubMed ID: 8263785
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Total steroidal alkaloids from Veratrum patulum L. Inhibit platelet aggregation, thrombi formation and decrease bleeding time in rats.
    Song Q; Wang S; Zhao W
    J Ethnopharmacol; 2012 May; 141(1):183-6. PubMed ID: 22366682
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Dual inhibition of HY023016 based on binding properties of platelet membrane receptor subunit glycoprotein Ibα and thrombin exosites.
    Chen QF; Cui S; Shen HL; Chen X; Li YZ; Wu Q; Xu YG; Gong GQ
    Eur J Pharmacol; 2018 Mar; 822():51-58. PubMed ID: 29355554
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Enhanced anticoagulant activity of enoxaparin in patients with ESRD as measured by thrombin generation time.
    Brophy DF; Martin EJ; Gehr TW; Carr ME
    Am J Kidney Dis; 2004 Aug; 44(2):270-7. PubMed ID: 15264185
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and in Vitro and in Vivo Anticoagulant and Antiplatelet Activities of Amidino- and Non-Amidinobenzamides.
    Lee SH; Lee W; Bae JS; Ma E
    Molecules; 2016 May; 21(5):. PubMed ID: 27213328
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.
    De Cristofaro R; De Filippis V
    Biochem J; 2003 Jul; 373(Pt 2):593-601. PubMed ID: 12689334
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Anti-metastatic effect of a non-anticoagulant low-molecular-weight heparin versus the standard low-molecular-weight heparin, enoxaparin.
    Mousa SA; Linhardt R; Francis JL; Amirkhosravi A
    Thromb Haemost; 2006 Dec; 96(6):816-21. PubMed ID: 17139378
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Kenaf Seed Cysteine Protease (KSCP) Inhibits the Intrinsic Pathway of the Blood Coagulation Cascade and Platelet Aggregation.
    Hanumegowda SM; Srinivasa C; Shivaiah A; Venkatappa MM; Shankar RL; Lakshmaiah RK; Gonchigar SJ; Sannaningaiah D
    Curr Protein Pept Sci; 2024; 25(5):394-408. PubMed ID: 38031777
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.