176 related articles for article (PubMed ID: 26811537)
1. The lipidome associated with the γ-secretase complex is required for its integrity and activity.
Ayciriex S; Gerber H; Osuna GM; Chami M; Stahlberg H; Shevchenko A; Fraering PC
Biochem J; 2016 Feb; 473(3):321-34. PubMed ID: 26811537
[TBL] [Abstract][Full Text] [Related]
2. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
[TBL] [Abstract][Full Text] [Related]
3. Regulation of gamma-secretase activity in Alzheimer's disease.
Zhou S; Zhou H; Walian PJ; Jap BK
Biochemistry; 2007 Mar; 46(10):2553-63. PubMed ID: 17298085
[TBL] [Abstract][Full Text] [Related]
4. Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer's disease.
Kanatsu K; Tomita T
Biol Chem; 2016 Sep; 397(9):827-35. PubMed ID: 27390881
[TBL] [Abstract][Full Text] [Related]
5. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
Winkler E; Hobson S; Fukumori A; Dümpelfeld B; Luebbers T; Baumann K; Haass C; Hopf C; Steiner H
Biochemistry; 2009 Feb; 48(6):1183-97. PubMed ID: 19159235
[TBL] [Abstract][Full Text] [Related]
6. Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
Feilen LP; Chen SY; Fukumori A; Feederle R; Zacharias M; Steiner H
Elife; 2022 May; 11():. PubMed ID: 35579427
[TBL] [Abstract][Full Text] [Related]
7. Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production.
Matz A; Halamoda-Kenzaoui B; Hamelin R; Mosser S; Alattia JR; Dimitrov M; Moniatte M; Fraering PC
J Neurochem; 2015 May; 133(3):409-21. PubMed ID: 25458374
[TBL] [Abstract][Full Text] [Related]
8. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
Laudon H; Winblad B; Näslund J
Physiol Behav; 2007 Sep; 92(1-2):115-20. PubMed ID: 17588625
[TBL] [Abstract][Full Text] [Related]
9. The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.
Stockley JH; O'Neill C
Biochem Soc Trans; 2007 Jun; 35(Pt 3):574-6. PubMed ID: 17511655
[TBL] [Abstract][Full Text] [Related]
10. γ-Secretase inhibitors and modulators.
Golde TE; Koo EH; Felsenstein KM; Osborne BA; Miele L
Biochim Biophys Acta; 2013 Dec; 1828(12):2898-907. PubMed ID: 23791707
[TBL] [Abstract][Full Text] [Related]
11. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.
Wolfe MS; Xia W; Moore CL; Leatherwood DD; Ostaszewski B; Rahmati T; Donkor IO; Selkoe DJ
Biochemistry; 1999 Apr; 38(15):4720-7. PubMed ID: 10200159
[TBL] [Abstract][Full Text] [Related]
12. The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.
Bolduc DM; Montagna DR; Seghers MC; Wolfe MS; Selkoe DJ
Elife; 2016 Aug; 5():. PubMed ID: 27580372
[TBL] [Abstract][Full Text] [Related]
13. Direct and potent regulation of gamma-secretase by its lipid microenvironment.
Osenkowski P; Ye W; Wang R; Wolfe MS; Selkoe DJ
J Biol Chem; 2008 Aug; 283(33):22529-40. PubMed ID: 18539594
[TBL] [Abstract][Full Text] [Related]
14. Substrate recruitment by γ-secretase.
Fukumori A; Feilen LP; Steiner H
Semin Cell Dev Biol; 2020 Sep; 105():54-63. PubMed ID: 32331992
[TBL] [Abstract][Full Text] [Related]
15. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.
Suárez-Calvet M; Belbin O; Pera M; Badiola N; Magrané J; Guardia-Laguarta C; Muñoz L; Colom-Cadena M; Clarimón J; Lleó A
J Neurochem; 2014 Jan; 128(2):330-9. PubMed ID: 24117942
[TBL] [Abstract][Full Text] [Related]
16. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
Zhou S; Zhou H; Walian PJ; Jap BK
Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
[TBL] [Abstract][Full Text] [Related]
17. Secretase inhibitors and modulators for Alzheimer's disease treatment.
Tomita T
Expert Rev Neurother; 2009 May; 9(5):661-79. PubMed ID: 19402777
[TBL] [Abstract][Full Text] [Related]
18. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
[TBL] [Abstract][Full Text] [Related]
19. A fast growing spectrum of biological functions of γ-secretase in development and disease.
Jurisch-Yaksi N; Sannerud R; Annaert W
Biochim Biophys Acta; 2013 Dec; 1828(12):2815-27. PubMed ID: 24099003
[TBL] [Abstract][Full Text] [Related]
20. Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.
Gamerdinger M; Clement AB; Behl C
Neuropharmacology; 2008 May; 54(6):998-1005. PubMed ID: 18359496
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]