132 related articles for article (PubMed ID: 26819670)
1. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.
Jones BD; Tochowicz A; Tang Y; Cameron MD; McCall LI; Hirata K; Siqueira-Neto JL; Reed SL; McKerrow JH; Roush WR
ACS Med Chem Lett; 2016 Jan; 7(1):77-82. PubMed ID: 26819670
[TBL] [Abstract][Full Text] [Related]
2. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
Chen YT; Brinen LS; Kerr ID; Hansell E; Doyle PS; McKerrow JH; Roush WR
PLoS Negl Trop Dis; 2010 Sep; 4(9):. PubMed ID: 20856868
[TBL] [Abstract][Full Text] [Related]
3. Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.
Scheidt KA; Roush WR; McKerrow JH; Selzer PM; Hansell E; Rosenthal PJ
Bioorg Med Chem; 1998 Dec; 6(12):2477-94. PubMed ID: 9925304
[TBL] [Abstract][Full Text] [Related]
4. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Brinen LS; Hansell E; Cheng J; Roush WR; McKerrow JH; Fletterick RJ
Structure; 2000 Aug; 8(8):831-40. PubMed ID: 10997902
[TBL] [Abstract][Full Text] [Related]
5. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.
Choe Y; Brinen LS; Price MS; Engel JC; Lange M; Grisostomi C; Weston SG; Pallai PV; Cheng H; Hardy LW; Hartsough DS; McMakin M; Tilton RF; Baldino CM; Craik CS
Bioorg Med Chem; 2005 Mar; 13(6):2141-56. PubMed ID: 15727867
[TBL] [Abstract][Full Text] [Related]
6. Cysteine protease inhibitors alter Golgi complex ultrastructure and function in Trypanosoma cruzi.
Engel JC; Doyle PS; Palmer J; Hsieh I; Bainton DF; McKerrow JH
J Cell Sci; 1998 Mar; 111 ( Pt 5)():597-606. PubMed ID: 9454733
[TBL] [Abstract][Full Text] [Related]
7. Intramolecular Interactions Enhance the Potency of Gallinamide A Analogues against
Barbosa Da Silva E; Sharma V; Hernandez-Alvarez L; Tang AH; Stoye A; O'Donoghue AJ; Gerwick WH; Payne RJ; McKerrow JH; Podust LM
J Med Chem; 2022 Mar; 65(5):4255-4269. PubMed ID: 35188371
[TBL] [Abstract][Full Text] [Related]
8. Assessment of the Cruzain Cysteine Protease Reversible and Irreversible Covalent Inhibition Mechanism.
Silva JRA; Cianni L; Araujo D; Batista PHJ; de Vita D; Rosini F; Leitão A; Lameira J; Montanari CA
J Chem Inf Model; 2020 Mar; 60(3):1666-1677. PubMed ID: 32126170
[TBL] [Abstract][Full Text] [Related]
9. Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents.
Ferreira RS; Dessoy MA; Pauli I; Souza ML; Krogh R; Sales AI; Oliva G; Dias LC; Andricopulo AD
J Med Chem; 2014 Mar; 57(6):2380-92. PubMed ID: 24533839
[TBL] [Abstract][Full Text] [Related]
10. Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.
Chenna BC; Li L; Mellott DM; Zhai X; Siqueira-Neto JL; Calvet Alvarez C; Bernatchez JA; Desormeaux E; Alvarez Hernandez E; Gomez J; McKerrow JH; Cruz-Reyes J; Meek TD
J Med Chem; 2020 Mar; 63(6):3298-3316. PubMed ID: 32125159
[TBL] [Abstract][Full Text] [Related]
11. Crystal structure of chagasin, the endogenous cysteine-protease inhibitor from Trypanosoma cruzi.
Figueiredo da Silva AA; de Carvalho Vieira L; Krieger MA; Goldenberg S; Zanchin NI; Guimarães BG
J Struct Biol; 2007 Feb; 157(2):416-23. PubMed ID: 17011790
[TBL] [Abstract][Full Text] [Related]
12. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy.
Lee GM; Balouch E; Goetz DH; Lazic A; McKerrow JH; Craik CS
Biochemistry; 2012 Dec; 51(50):10087-98. PubMed ID: 23181936
[TBL] [Abstract][Full Text] [Related]
13. Cruzain structures: apocruzain and cruzain bound to S-methyl thiomethanesulfonate and implications for drug design.
Barbosa da Silva E; Dall E; Briza P; Brandstetter H; Ferreira RS
Acta Crystallogr F Struct Biol Commun; 2019 Jun; 75(Pt 6):419-427. PubMed ID: 31204688
[TBL] [Abstract][Full Text] [Related]
14. Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis.
Huang L; Lee A; Ellman JA
J Med Chem; 2002 Jan; 45(3):676-84. PubMed ID: 11806719
[TBL] [Abstract][Full Text] [Related]
15. Structural determinants of specificity in the cysteine protease cruzain.
Gillmor SA; Craik CS; Fletterick RJ
Protein Sci; 1997 Aug; 6(8):1603-11. PubMed ID: 9260273
[TBL] [Abstract][Full Text] [Related]
16. A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.
Doyle PS; Zhou YM; Engel JC; McKerrow JH
Antimicrob Agents Chemother; 2007 Nov; 51(11):3932-9. PubMed ID: 17698625
[TBL] [Abstract][Full Text] [Related]
17. Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.
Lima AP; dos Reis FC; Serveau C; Lalmanach G; Juliano L; Ménard R; Vernet T; Thomas DY; Storer AC; Scharfstein J
Mol Biochem Parasitol; 2001 Apr; 114(1):41-52. PubMed ID: 11356512
[TBL] [Abstract][Full Text] [Related]
18. Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain.
Huang L; Brinen LS; Ellman JA
Bioorg Med Chem; 2003 Jan; 11(1):21-9. PubMed ID: 12467703
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of cysteine proteases by a natural biflavone: behavioral evaluation of fukugetin as papain and cruzain inhibitor.
Assis DM; Gontijo VS; de Oliveira Pereira I; Santos JA; Camps I; Nagem TJ; Ellena J; Izidoro MA; dos Santos Tersariol IL; de Barros NM; Doriguetto AC; dos Santos MH; Juliano MA
J Enzyme Inhib Med Chem; 2013 Aug; 28(4):661-70. PubMed ID: 22468751
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.
Espíndola JW; Cardoso MV; Filho GB; Oliveira E Silva DA; Moreira DR; Bastos TM; Simone CA; Soares MB; Villela FS; Ferreira RS; Castro MC; Pereira VR; Murta SM; Sales Junior PA; Romanha AJ; Leite AC
Eur J Med Chem; 2015 Aug; 101():818-35. PubMed ID: 26231082
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]