These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

448 related articles for article (PubMed ID: 26831078)

  • 1. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
    Mullarky E; Lucki NC; Beheshti Zavareh R; Anglin JL; Gomes AP; Nicolay BN; Wong JC; Christen S; Takahashi H; Singh PK; Blenis J; Warren JD; Fendt SM; Asara JM; DeNicola GM; Lyssiotis CA; Lairson LL; Cantley LC
    Proc Natl Acad Sci U S A; 2016 Feb; 113(7):1778-83. PubMed ID: 26831078
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
    Mullarky E; Xu J; Robin AD; Huggins DJ; Jennings A; Noguchi N; Olland A; Lakshminarasimhan D; Miller M; Tomita D; Michino M; Su T; Zhang G; Stamford AW; Meinke PT; Kargman S; Cantley LC
    Bioorg Med Chem Lett; 2019 Sep; 29(17):2503-2510. PubMed ID: 31327531
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity.
    Wang Q; Liberti MV; Liu P; Deng X; Liu Y; Locasale JW; Lai L
    Cell Chem Biol; 2017 Jan; 24(1):55-65. PubMed ID: 28042046
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer.
    Zhao X; Fu J; Du J; Xu W
    Int J Biol Sci; 2020; 16(9):1495-1506. PubMed ID: 32226297
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.
    Pacold ME; Brimacombe KR; Chan SH; Rohde JM; Lewis CA; Swier LJ; Possemato R; Chen WW; Sullivan LB; Fiske BP; Cho S; Freinkman E; Birsoy K; Abu-Remaileh M; Shaul YD; Liu CM; Zhou M; Koh MJ; Chung H; Davidson SM; Luengo A; Wang AQ; Xu X; Yasgar A; Liu L; Rai G; Westover KD; Vander Heiden MG; Shen M; Gray NS; Boxer MB; Sabatini DM
    Nat Chem Biol; 2016 Jun; 12(6):452-8. PubMed ID: 27110680
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy.
    Zhou X; Tan Y; Gou K; Tao L; Luo Y; Zhou Y; Zuo Z; Sun Q; Luo Y; Zhao Y
    Bioorg Chem; 2021 Oct; 115():105159. PubMed ID: 34298241
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
    Arlt B; Zasada C; Baum K; Wuenschel J; Mastrobuoni G; Lodrini M; Astrahantseff K; Winkler A; Schulte JH; Finkler S; Forbes M; Hundsdoerfer P; Guergen D; Hoffmann J; Wolf J; Eggert A; Kempa S; Deubzer HE
    Int J Cancer; 2021 Mar; 148(5):1219-1232. PubMed ID: 33284994
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.
    Guo J; Gu X; Zheng M; Zhang Y; Chen L; Li H
    Bioorg Chem; 2019 Jun; 87():16-22. PubMed ID: 30852233
    [TBL] [Abstract][Full Text] [Related]  

  • 9. p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation.
    Ou Y; Wang SJ; Jiang L; Zheng B; Gu W
    J Biol Chem; 2015 Jan; 290(1):457-66. PubMed ID: 25404730
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism.
    Zhao JY; Feng KR; Wang F; Zhang JW; Cheng JF; Lin GQ; Gao D; Tian P
    Eur J Med Chem; 2021 May; 217():113379. PubMed ID: 33756126
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor
    Weinstabl H; Treu M; Rinnenthal J; Zahn SK; Ettmayer P; Bader G; Dahmann G; Kessler D; Rumpel K; Mischerikow N; Savarese F; Gerstberger T; Mayer M; Zoephel A; Schnitzer R; Sommergruber W; Martinelli P; Arnhof H; Peric-Simov B; Hofbauer KS; Garavel G; Scherbantin Y; Mitzner S; Fett TN; Scholz G; Bruchhaus J; Burkard M; Kousek R; Ciftci T; Sharps B; Schrenk A; Harrer C; Haering D; Wolkerstorfer B; Zhang X; Lv X; Du A; Li D; Li Y; Quant J; Pearson M; McConnell DB
    J Med Chem; 2019 Sep; 62(17):7976-7997. PubMed ID: 31365252
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer.
    Itoyama R; Yasuda-Yoshihara N; Kitamura F; Yasuda T; Bu L; Yonemura A; Uchihara T; Arima K; Hu X; Jun Z; Okamoto Y; Akiyama T; Yamashita K; Nakao Y; Yusa T; Kitano Y; Higashi T; Miyata T; Imai K; Hayashi H; Yamashita YI; Mikawa T; Kondoh H; Baba H; Ishimoto T
    Cancer Lett; 2021 Dec; 523():29-42. PubMed ID: 34508795
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
    Possemato R; Marks KM; Shaul YD; Pacold ME; Kim D; Birsoy K; Sethumadhavan S; Woo HK; Jang HG; Jha AK; Chen WW; Barrett FG; Stransky N; Tsun ZY; Cowley GS; Barretina J; Kalaany NY; Hsu PP; Ottina K; Chan AM; Yuan B; Garraway LA; Root DE; Mino-Kenudson M; Brachtel EF; Driggers EM; Sabatini DM
    Nature; 2011 Aug; 476(7360):346-50. PubMed ID: 21760589
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment.
    Sadiqa A; Rasul A; Hassan M; Sultana S; Jabeen F
    Molecules; 2022 Sep; 27(18):. PubMed ID: 36144843
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The NAD
    Murphy JP; Giacomantonio MA; Paulo JA; Everley RA; Kennedy BE; Pathak GP; Clements DR; Kim Y; Dai C; Sharif T; Gygi SP; Gujar S
    Cell Rep; 2018 Aug; 24(9):2381-2391.e5. PubMed ID: 30157431
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Ixocarpalactone A from dietary tomatillo inhibits pancreatic cancer growth by targeting PHGDH.
    Zheng M; Guo J; Xu J; Yang K; Tang R; Gu X; Li H; Chen L
    Food Funct; 2019 Jun; 10(6):3386-3395. PubMed ID: 31112178
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PHGDH: a novel therapeutic target in cancer.
    Lee CM; Hwang Y; Kim M; Park YC; Kim H; Fang S
    Exp Mol Med; 2024 Jul; 56(7):1513-1522. PubMed ID: 38945960
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
    Rohde JM; Brimacombe KR; Liu L; Pacold ME; Yasgar A; Cheff DM; Lee TD; Rai G; Baljinnyam B; Li Z; Simeonov A; Hall MD; Shen M; Sabatini DM; Boxer MB
    Bioorg Med Chem; 2018 May; 26(8):1727-1739. PubMed ID: 29555419
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.
    Ma X; Li B; Liu J; Fu Y; Luo Y
    J Exp Clin Cancer Res; 2019 Feb; 38(1):66. PubMed ID: 30744688
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells.
    Sharif T; Martell E; Dai C; Ghassemi-Rad MS; Lee K; Singh SK; Weaver ICG; Gujar S
    Cell Death Dis; 2018 Sep; 9(10):990. PubMed ID: 30250195
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.