These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
175 related articles for article (PubMed ID: 26851239)
1. Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG. Bonn B; Svanberg P; Janefeldt A; Hultman Ia; Grime K Drug Metab Dispos; 2016 Apr; 44(4):527-33. PubMed ID: 26851239 [TBL] [Abstract][Full Text] [Related]
2. Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs. Zanelli U; Caradonna NP; Hallifax D; Turlizzi E; Houston JB Drug Metab Dispos; 2012 Jan; 40(1):104-10. PubMed ID: 21998403 [TBL] [Abstract][Full Text] [Related]
3. Comparison of fresh and cryopreserved rat hepatocyte suspensions for the prediction of in vitro intrinsic clearance. Griffin SJ; Houston JB Drug Metab Dispos; 2004 May; 32(5):552-8. PubMed ID: 15100178 [TBL] [Abstract][Full Text] [Related]
4. Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds. Hultman Ia; Vedin C; Abrahamsson A; Winiwarter S; Darnell M Mol Pharm; 2016 Aug; 13(8):2796-807. PubMed ID: 27377099 [TBL] [Abstract][Full Text] [Related]
5. Prediction of in vitro intrinsic clearance from hepatocytes: comparison of suspensions and monolayer cultures. Griffin SJ; Houston JB Drug Metab Dispos; 2005 Jan; 33(1):115-20. PubMed ID: 15608354 [TBL] [Abstract][Full Text] [Related]
6. Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes. Floby E; Johansson J; Hoogstraate J; Hewitt NJ; Hill J; Sohlenius-Sternbeck AK Xenobiotica; 2009 Sep; 39(9):656-62. PubMed ID: 19622023 [TBL] [Abstract][Full Text] [Related]
7. Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds. Sohlenius-Sternbeck AK; Afzelius L; Prusis P; Neelissen J; Hoogstraate J; Johansson J; Floby E; Bengtsson A; Gissberg O; Sternbeck J; Petersson C Xenobiotica; 2010 Sep; 40(9):637-49. PubMed ID: 20624033 [TBL] [Abstract][Full Text] [Related]
8. Comparison of Human Long-Term Liver Models for Clearance Prediction of Slowly Metabolized Compounds. Preiss LC; Georgi K; Lauschke VM; Petersson C Drug Metab Dispos; 2024 May; 52(6):539-547. PubMed ID: 38604730 [TBL] [Abstract][Full Text] [Related]
9. Relationship between passive permeability, efflux, and predictability of clearance from in vitro metabolic intrinsic clearance. Huang L; Berry L; Ganga S; Janosky B; Chen A; Roberts J; Colletti AE; Lin MH Drug Metab Dispos; 2010 Feb; 38(2):223-31. PubMed ID: 19875499 [TBL] [Abstract][Full Text] [Related]
10. HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro. Lübberstedt M; Müller-Vieira U; Mayer M; Biemel KM; Knöspel F; Knobeloch D; Nüssler AK; Gerlach JC; Zeilinger K J Pharmacol Toxicol Methods; 2011; 63(1):59-68. PubMed ID: 20460162 [TBL] [Abstract][Full Text] [Related]
11. Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo. Soars MG; Grime K; Sproston JL; Webborn PJ; Riley RJ Drug Metab Dispos; 2007 Jun; 35(6):859-65. PubMed ID: 17344337 [TBL] [Abstract][Full Text] [Related]
12. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance. Brown HS; Griffin M; Houston JB Drug Metab Dispos; 2007 Feb; 35(2):293-301. PubMed ID: 17132764 [TBL] [Abstract][Full Text] [Related]
13. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes. Riley RJ; McGinnity DF; Austin RP Drug Metab Dispos; 2005 Sep; 33(9):1304-11. PubMed ID: 15932954 [TBL] [Abstract][Full Text] [Related]
14. Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds. Huang L; Chen A; Roberts J; Janosky B; Be X; Berry L; Lin MH Xenobiotica; 2012 Sep; 42(9):830-40. PubMed ID: 22439758 [TBL] [Abstract][Full Text] [Related]
15. Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists. Hutzler JM; Ring BJ; Anderson SR Drug Metab Dispos; 2015 Dec; 43(12):1917-28. PubMed ID: 26363026 [TBL] [Abstract][Full Text] [Related]
16. Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance. Foster JA; Houston JB; Hallifax D Xenobiotica; 2011 Feb; 41(2):124-36. PubMed ID: 21058916 [TBL] [Abstract][Full Text] [Related]
17. Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac. Chan TS; Yu H; Moore A; Khetani SR; Tweedie D Drug Metab Dispos; 2013 Dec; 41(12):2024-32. PubMed ID: 23959596 [TBL] [Abstract][Full Text] [Related]
18. Assessment of the Biotransformation of Low-Turnover Drugs in the H Burton RD; Hieronymus T; Chamem T; Heim D; Anderson S; Zhu X; Hutzler JM Drug Metab Dispos; 2018 Nov; 46(11):1617-1625. PubMed ID: 30135244 [TBL] [Abstract][Full Text] [Related]
19. Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance. Fagerholm U J Pharm Pharmacol; 2007 Jun; 59(6):803-28. PubMed ID: 17637173 [TBL] [Abstract][Full Text] [Related]
20. Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations. Blanchard N; Hewitt NJ; Silber P; Jones H; Coassolo P; Lavé T J Pharm Pharmacol; 2006 May; 58(5):633-41. PubMed ID: 16640832 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]