These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

175 related articles for article (PubMed ID: 26851239)

  • 21. Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro.
    Naritomi Y; Terashita S; Kagayama A; Sugiyama Y
    Drug Metab Dispos; 2003 May; 31(5):580-8. PubMed ID: 12695346
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Development and Characterization of a Human Hepatocyte Low Intrinsic Clearance Assay for Use in Drug Discovery.
    Lancett P; Williamson B; Barton P; Riley RJ
    Drug Metab Dispos; 2018 Aug; 46(8):1169-1178. PubMed ID: 29880630
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Metabolite formation kinetics and intrinsic clearance of phenacetin, tolbutamide, alprazolam, and midazolam in adenoviral cytochrome P450-transfected HepG2 cells and comparison with hepatocytes and in vivo.
    Donato MT; Hallifax D; Picazo L; Castell JV; Houston JB; Gomez-Lechón MJ; Lahoz A
    Drug Metab Dispos; 2010 Sep; 38(9):1449-55. PubMed ID: 20501911
    [TBL] [Abstract][Full Text] [Related]  

  • 24. A practical and direct comparison of intrinsic metabolic clearance of several non-CYP enzyme substrates in freshly isolated and cryopreserved hepatocytes.
    Akabane T; Gerst N; Naritomi Y; Masters JN; Tamura K
    Drug Metab Pharmacokinet; 2012; 27(2):181-91. PubMed ID: 22027494
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations.
    Jones HM; Houston JB
    Drug Metab Dispos; 2004 Sep; 32(9):973-82. PubMed ID: 15319339
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Micropatterned Co-Cultures of Human Hepatocytes and Stromal Cells for the Assessment of Drug Clearance and Drug-Drug Interactions.
    Lin C; Khetani SR
    Curr Protoc Toxicol; 2017 May; 72():14.17.1-14.17.23. PubMed ID: 28463419
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice.
    Watari R; Kakiki M; Yamasaki C; Ishida Y; Tateno C; Kuroda Y; Ishida S; Kusano K
    Biol Pharm Bull; 2019; 42(3):348-353. PubMed ID: 30828066
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions.
    Stringer RA; Strain-Damerell C; Nicklin P; Houston JB
    Drug Metab Dispos; 2009 May; 37(5):1025-34. PubMed ID: 19196847
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Evaluation and Optimization of a Microcavity Plate-Based Human Hepatocyte Spheroid Model for Predicting Clearance of Slowly Metabolized Drug Candidates.
    Kukla DA; Belair DG; Stresser DM
    Drug Metab Dispos; 2024 Jul; 52(8):797-812. PubMed ID: 38777596
    [TBL] [Abstract][Full Text] [Related]  

  • 30. In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes.
    Nakakariya M; Ono M; Amano N; Moriwaki T; Maeda K; Sugiyama Y
    Drug Metab Dispos; 2012 Mar; 40(3):602-9. PubMed ID: 22190695
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Upcyte Human Hepatocytes: a Potent In Vitro Tool for the Prediction of Hepatic Clearance of Metabolically Stable Compounds.
    Schaefer M; Schänzle G; Bischoff D; Süssmuth RD
    Drug Metab Dispos; 2016 Mar; 44(3):435-44. PubMed ID: 26712819
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Qualitative and quantitative prediction of human in vivo metabolic pathways in a human hepatocyte-murine stromal cell co-culture model.
    Cassidy KC; Yi P
    Xenobiotica; 2018 Dec; 48(12):1192-1205. PubMed ID: 29143555
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes.
    Ito K; Houston JB
    Pharm Res; 2004 May; 21(5):785-92. PubMed ID: 15180335
    [TBL] [Abstract][Full Text] [Related]  

  • 34. A Novel Plated Hepatocyte Relay Assay (PHRA) for In Vitro Evaluation of Hepatic Metabolic Clearance of Slowly Metabolized Compounds.
    Peng CC; Doshi U; Prakash C; Li AP
    Drug Metab Lett; 2016; 10(1):3-15. PubMed ID: 26282592
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes.
    Lau YY; Sapidou E; Cui X; White RE; Cheng KC
    Drug Metab Dispos; 2002 Dec; 30(12):1446-54. PubMed ID: 12433818
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Prediction of metabolic clearance using cryopreserved human hepatocytes: kinetic characteristics for five benzodiazepines.
    Hallifax D; Rawden HC; Hakooz N; Houston JB
    Drug Metab Dispos; 2005 Dec; 33(12):1852-8. PubMed ID: 16174807
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Reliability of human cryopreserved hepatocytes and liver microsomes as in vitro systems to predict metabolic clearance.
    Stringer R; Nicklin PL; Houston JB
    Xenobiotica; 2008 Oct; 38(10):1313-29. PubMed ID: 18853387
    [TBL] [Abstract][Full Text] [Related]  

  • 38. In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system.
    Darnell M; Ulvestad M; Ellis E; Weidolf L; Andersson TB
    J Pharmacol Exp Ther; 2012 Oct; 343(1):134-44. PubMed ID: 22776955
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Toward a new paradigm for the efficient in vitro-in vivo extrapolation of metabolic clearance in humans from hepatocyte data.
    Poulin P; Haddad S
    J Pharm Sci; 2013 Sep; 102(9):3239-51. PubMed ID: 23494893
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac.
    Chan TS; Yu H; Moore A; Khetani SR; Tweedie D
    Drug Metab Dispos; 2019 Jan; 47(1):58-66. PubMed ID: 30552098
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 9.