104 related articles for article (PubMed ID: 26854727)
1. The selectivity and promiscuity of brain-neuroregenerative inhibitors between ROCK1 and ROCK2 isoforms: An integration of SB-QSSR modelling, QM/MM analysis and in vitro kinase assay.
Zhu L; Yang Y; Lu X
SAR QSAR Environ Res; 2016; 27(1):47-65. PubMed ID: 26854727
[TBL] [Abstract][Full Text] [Related]
2. Discovery of bis-aryl urea derivatives as potent and selective Limk inhibitors: Exploring Limk1 activity and Limk1/ROCK2 selectivity through a combined computational study.
Cui J; Ding M; Deng W; Yin Y; Wang Z; Zhou H; Sun G; Jiang Y; Feng Y
Bioorg Med Chem; 2015 Dec; 23(23):7464-77. PubMed ID: 26545798
[TBL] [Abstract][Full Text] [Related]
3. Discovery of (S)-6-methoxy-chroman-3-carboxylic acid (4-pyridin-4-yl-phenyl)-amide as potent and isoform selective ROCK2 inhibitors.
Pan J; Yin Y; Zhao L; Feng Y
Bioorg Med Chem; 2019 Apr; 27(7):1382-1390. PubMed ID: 30819619
[TBL] [Abstract][Full Text] [Related]
4. Activation of Rho kinase isoforms in lung endothelial cells during inflammation.
Mong PY; Wang Q
J Immunol; 2009 Feb; 182(4):2385-94. PubMed ID: 19201893
[TBL] [Abstract][Full Text] [Related]
5. Discovery of Rho-kinase inhibitors by docking-based virtual screening.
Shen M; Yu H; Li Y; Li P; Pan P; Zhou S; Zhang L; Li S; Lee SM; Hou T
Mol Biosyst; 2013 Jun; 9(6):1511-21. PubMed ID: 23549429
[TBL] [Abstract][Full Text] [Related]
6. Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations.
Shen M; Zhou S; Li Y; Pan P; Zhang L; Hou T
Mol Biosyst; 2013 Mar; 9(3):361-74. PubMed ID: 23340525
[TBL] [Abstract][Full Text] [Related]
7. Distinct and complementary functions of rho kinase isoforms ROCK1 and ROCK2 in prefrontal cortex structural plasticity.
Greathouse KM; Boros BD; Deslauriers JF; Henderson BW; Curtis KA; Gentry EG; Herskowitz JH
Brain Struct Funct; 2018 Dec; 223(9):4227-4241. PubMed ID: 30196430
[TBL] [Abstract][Full Text] [Related]
8. Phthalazinone-based lactams and cyclic ureas as ROCK2 selective inhibitors.
Hu Z; Sitkoff D; Glunz PW; Zou Y; Wang C; Muckelbauer JK; Adam LP; Wexler RR; Quan ML
Bioorg Med Chem Lett; 2023 May; 88():129304. PubMed ID: 37119973
[TBL] [Abstract][Full Text] [Related]
9. Distinct distribution and localization of Rho-kinase in mouse epithelial, muscle and neural tissues.
Iizuka M; Kimura K; Wang S; Kato K; Amano M; Kaibuchi K; Mizoguchi A
Cell Struct Funct; 2012; 37(2):155-75. PubMed ID: 22986902
[TBL] [Abstract][Full Text] [Related]
10. Distinct roles of ROCK1 and ROCK2 during development of porcine preimplantation embryos.
Zhang JY; Dong HS; Oqani RK; Lin T; Kang JW; Jin DI
Reproduction; 2014 Jul; 148(1):99-107. PubMed ID: 24803490
[TBL] [Abstract][Full Text] [Related]
11. Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
Green J; Cao J; Bandarage UK; Gao H; Court J; Marhefka C; Jacobs M; Taslimi P; Newsome D; Nakayama T; Shah S; Rodems S
J Med Chem; 2015 Jun; 58(12):5028-37. PubMed ID: 26039570
[TBL] [Abstract][Full Text] [Related]
12. Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design.
Hobson AD; Judge RA; Aguirre AL; Brown BS; Cui Y; Ding P; Dominguez E; DiGiammarino E; Egan DA; Freiberg GM; Gopalakrishnan SM; Harris CM; Honore MP; Kage KL; Kapecki NJ; Ling C; Ma J; Mack H; Mamo M; Maurus S; McRae B; Moore NS; Mueller BK; Mueller R; Namovic MT; Patel K; Pratt SD; Putman CB; Queeney KL; Sarris KK; Schaffter LM; Stoll V; Vasudevan A; Wang L; Wang L; Wirthl W; Yach K
J Med Chem; 2018 Dec; 61(24):11074-11100. PubMed ID: 30384606
[TBL] [Abstract][Full Text] [Related]
13. The small-molecule inhibitor selectivity between IKKα and IKKβ kinases in NF-κB signaling pathway.
Tian F; Zhou P; Kang W; Luo L; Fan X; Yan J; Liang H
J Recept Signal Transduct Res; 2015; 35(4):307-18. PubMed ID: 25386663
[TBL] [Abstract][Full Text] [Related]
14. Rho-associated protein kinase isoforms stimulate proliferation of vascular smooth muscle cells through ERK and induction of cyclin D1 and PCNA.
Zhao Y; Lv M; Lin H; Cui Y; Wei X; Qin Y; Kohama K; Gao Y
Biochem Biophys Res Commun; 2013 Mar; 432(3):488-93. PubMed ID: 23402758
[TBL] [Abstract][Full Text] [Related]
15. Opposing signaling of ROCK1 and ROCK2 determines the switching of substrate specificity and the mode of migration of glioblastoma cells.
Mertsch S; Thanos S
Mol Neurobiol; 2014 Apr; 49(2):900-15. PubMed ID: 24170433
[TBL] [Abstract][Full Text] [Related]
16. Discovery of unglycosylated indolocarbazoles as ROCK2 isoform-selective inhibitors for the treatment of breast cancer metastasis.
Wang J; Gao T; Ma Y; Zhang Y; Yi Y; Yan F; Cheng Z; Yu Y; Li J; Chen Z; Ding W; Ma Z
Eur J Med Chem; 2023 Mar; 250():115181. PubMed ID: 36764122
[TBL] [Abstract][Full Text] [Related]
17. Rho kinase (ROCK) inhibitors.
Liao JK; Seto M; Noma K
J Cardiovasc Pharmacol; 2007 Jul; 50(1):17-24. PubMed ID: 17666911
[TBL] [Abstract][Full Text] [Related]
18. High-throughput screening against ~6.1 million structurally diverse, lead-like compounds to discover novel ROCK inhibitors for cerebral injury recovery.
Gong H; Yuan Z; Zhan L
Mol Divers; 2016 May; 20(2):537-49. PubMed ID: 26700101
[TBL] [Abstract][Full Text] [Related]
19. Stepwise high-throughput virtual screening of Rho kinase inhibitors from natural product library and potential therapeutics for pulmonary hypertension.
Su H; Yan J; Xu J; Fan XZ; Sun XL; Chen KY
Pharm Biol; 2015 Aug; 53(8):1201-6. PubMed ID: 25853972
[TBL] [Abstract][Full Text] [Related]
20. Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays.
Shen M; Tian S; Pan P; Sun H; Li D; Li Y; Zhou H; Li C; Lee SM; Hou T
Sci Rep; 2015 Nov; 5():16749. PubMed ID: 26568382
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]