124 related articles for article (PubMed ID: 26876228)
1. Protonation state of F420H2 in the prodrug-activating deazaflavin dependent nitroreductase (Ddn) from Mycobacterium tuberculosis.
Mohamed AE; Ahmed FH; Arulmozhiraja S; Lin CY; Taylor MC; Krausz ER; Jackson CJ; Coote ML
Mol Biosyst; 2016 Apr; 12(4):1110-3. PubMed ID: 26876228
[TBL] [Abstract][Full Text] [Related]
2. Structure of Ddn, the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis involved in bioreductive activation of PA-824.
Cellitti SE; Shaffer J; Jones DH; Mukherjee T; Gurumurthy M; Bursulaya B; Boshoff HI; Choi I; Nayyar A; Lee YS; Cherian J; Niyomrattanakit P; Dick T; Manjunatha UH; Barry CE; Spraggon G; Geierstanger BH
Structure; 2012 Jan; 20(1):101-12. PubMed ID: 22244759
[TBL] [Abstract][Full Text] [Related]
3. Molecular dynamic assisted investigation on impact of mutations in deazaflavin dependent nitroreductase against pretomanid: a computational study.
Singh R; Shaheer M; Sobhia ME
J Biomol Struct Dyn; 2023 Jul; 41(10):4421-4443. PubMed ID: 35574601
[TBL] [Abstract][Full Text] [Related]
4. Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.
Johansson E; Parkinson GN; Denny WA; Neidle S
J Med Chem; 2003 Sep; 46(19):4009-20. PubMed ID: 12954054
[TBL] [Abstract][Full Text] [Related]
5. Substrate specificity of the deazaflavin-dependent nitroreductase from Mycobacterium tuberculosis responsible for the bioreductive activation of bicyclic nitroimidazoles.
Gurumurthy M; Mukherjee T; Dowd CS; Singh R; Niyomrattanakit P; Tay JA; Nayyar A; Lee YS; Cherian J; Boshoff HI; Dick T; Barry CE; Manjunatha UH
FEBS J; 2012 Jan; 279(1):113-25. PubMed ID: 22023140
[TBL] [Abstract][Full Text] [Related]
6. Discovery and characterization of an F
Nguyen QT; Trinco G; Binda C; Mattevi A; Fraaije MW
Appl Microbiol Biotechnol; 2017 Apr; 101(7):2831-2842. PubMed ID: 27966048
[TBL] [Abstract][Full Text] [Related]
7. Mechanism of CB1954 reduction by Escherichia coli nitroreductase.
Christofferson A; Wilkie J
Biochem Soc Trans; 2009 Apr; 37(Pt 2):413-8. PubMed ID: 19290872
[TBL] [Abstract][Full Text] [Related]
8. F420H2 Is Required for Phthiocerol Dimycocerosate Synthesis in Mycobacteria.
Purwantini E; Daniels L; Mukhopadhyay B
J Bacteriol; 2016 Aug; 198(15):2020-8. PubMed ID: 27185825
[TBL] [Abstract][Full Text] [Related]
9. Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.
Negri A; Javidnia P; Mu R; Zhang X; Vendome J; Gold B; Roberts J; Barman D; Ioerger T; Sacchettini JC; Jiang X; Burns-Huang K; Warrier T; Ling Y; Warren JD; Oren DA; Beuming T; Wang H; Wu J; Li H; Rhee KY; Nathan CF; Liu G; Somersan-Karakaya S
ACS Infect Dis; 2018 May; 4(5):771-787. PubMed ID: 29465985
[TBL] [Abstract][Full Text] [Related]
10. Design of 2-Nitroimidazooxazine Derivatives as Deazaflavin-Dependent Nitroreductase (Ddn) Activators as Anti-Mycobacterial Agents Based on 3D QSAR, HQSAR, and Docking Study with In Silico Prediction of Activity and Toxicity.
Gupta N; Vyas VK; Patel BD; Ghate M
Interdiscip Sci; 2019 Jun; 11(2):191-205. PubMed ID: 28895050
[TBL] [Abstract][Full Text] [Related]
11. Nitroreductase from Bacillus licheniformis: a stable enzyme for prodrug activation.
Emptage CD; Knox RJ; Danson MJ; Hough DW
Biochem Pharmacol; 2009 Jan; 77(1):21-9. PubMed ID: 18840409
[TBL] [Abstract][Full Text] [Related]
12. Hydrophobic Shielding Drives Catalysis of Hydride Transfer in a Family of F
Mohamed AE; Condic-Jurkic K; Ahmed FH; Yuan P; O'Mara ML; Jackson CJ; Coote ML
Biochemistry; 2016 Dec; 55(49):6908-6918. PubMed ID: 27951661
[TBL] [Abstract][Full Text] [Related]
13. Identification of novel nitroreductases from Bacillus cereus and their interaction with the CB1954 prodrug.
Gwenin VV; Poornima P; Halliwell J; Ball P; Robinson G; Gwenin CD
Biochem Pharmacol; 2015 Dec; 98(3):392-402. PubMed ID: 26415543
[TBL] [Abstract][Full Text] [Related]
14. Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).
Cherian J; Choi I; Nayyar A; Manjunatha UH; Mukherjee T; Lee YS; Boshoff HI; Singh R; Ha YH; Goodwin M; Lakshminarayana SB; Niyomrattanakit P; Jiricek J; Ravindran S; Dick T; Keller TH; Dartois V; Barry CE
J Med Chem; 2011 Aug; 54(16):5639-59. PubMed ID: 21755942
[TBL] [Abstract][Full Text] [Related]
15. Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.
AbuKhader M; Heap J; De Matteis C; Kellam B; Doughty SW; Minton N; Paoli M
J Med Chem; 2005 Dec; 48(24):7714-9. PubMed ID: 16302811
[TBL] [Abstract][Full Text] [Related]
16. Crystal structure of reduced MsAcg, a putative nitroreductase from Mycobacterium smegmatis and a close homologue of Mycobacterium tuberculosis Acg.
Chauviac FX; Bommer M; Yan J; Parkin G; Daviter T; Lowden P; Raven EL; Thalassinos K; Keep NH
J Biol Chem; 2012 Dec; 287(53):44372-83. PubMed ID: 23148223
[TBL] [Abstract][Full Text] [Related]
17. 2-((3,5-Dinitrobenzyl)thio)quinazolinones: Potent Antimycobacterial Agents Activated by Deazaflavin (F
Jian Y; Forbes HE; Hulpia F; Risseeuw MDP; Caljon G; Munier-Lehmann H; Boshoff HIM; Van Calenbergh S
J Med Chem; 2021 Jan; 64(1):440-457. PubMed ID: 33347317
[TBL] [Abstract][Full Text] [Related]
18. Modification of existing antibiotics in the form of precursor prodrugs that can be subsequently activated by nitroreductases of the target pathogen.
Çelik A; Yetiş G; Ay M; Güngör T
Bioorg Med Chem Lett; 2016 Aug; 26(16):4057-60. PubMed ID: 27390065
[TBL] [Abstract][Full Text] [Related]
19. Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering.
Lee BM; Harold LK; Almeida DV; Afriat-Jurnou L; Aung HL; Forde BM; Hards K; Pidot SJ; Ahmed FH; Mohamed AE; Taylor MC; West NP; Stinear TP; Greening C; Beatson SA; Nuermberger EL; Cook GM; Jackson CJ
PLoS Pathog; 2020 Feb; 16(2):e1008287. PubMed ID: 32032366
[TBL] [Abstract][Full Text] [Related]
20. Colloidal gold modified with a genetically engineered nitroreductase: toward a novel enzyme delivery system for cancer prodrug therapy.
Gwenin VV; Gwenin CD; Kalaji M
Langmuir; 2011 Dec; 27(23):14300-7. PubMed ID: 22014024
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]