228 related articles for article (PubMed ID: 26878343)
1. Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.
Pelz NF; Bian Z; Zhao B; Shaw S; Tarr JC; Belmar J; Gregg C; Camper DV; Goodwin CM; Arnold AL; Sensintaffar JL; Friberg A; Rossanese OW; Lee T; Olejniczak ET; Fesik SW
J Med Chem; 2016 Mar; 59(5):2054-66. PubMed ID: 26878343
[TBL] [Abstract][Full Text] [Related]
2. Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.
Burke JP; Bian Z; Shaw S; Zhao B; Goodwin CM; Belmar J; Browning CF; Vigil D; Friberg A; Camper DV; Rossanese OW; Lee T; Olejniczak ET; Fesik SW
J Med Chem; 2015 May; 58(9):3794-805. PubMed ID: 25844895
[TBL] [Abstract][Full Text] [Related]
3. Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors.
Follows B; Fessler S; Baumeister T; Campbell AM; Zablocki MM; Li H; Gotur D; Wang Z; Zheng X; Molz L; Nguyen C; Herbertz T; Wang L; Bair K
Bioorg Med Chem Lett; 2019 Aug; 29(16):2375-2382. PubMed ID: 31235261
[TBL] [Abstract][Full Text] [Related]
4. Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.
Shaw S; Bian Z; Zhao B; Tarr JC; Veerasamy N; Jeon KO; Belmar J; Arnold AL; Fogarty SA; Perry E; Sensintaffar JL; Camper DV; Rossanese OW; Lee T; Olejniczak ET; Fesik SW
J Med Chem; 2018 Mar; 61(6):2410-2421. PubMed ID: 29323899
[TBL] [Abstract][Full Text] [Related]
5. Discovery of novel indazole-acylsulfonamide hybrids as selective Mcl-1 inhibitors.
Wan Y; Li Y; Yan C; Wen J; Tang Z
Bioorg Chem; 2020 Nov; 104():104217. PubMed ID: 32911192
[TBL] [Abstract][Full Text] [Related]
6. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
Friberg A; Vigil D; Zhao B; Daniels RN; Burke JP; Garcia-Barrantes PM; Camper D; Chauder BA; Lee T; Olejniczak ET; Fesik SW
J Med Chem; 2013 Jan; 56(1):15-30. PubMed ID: 23244564
[TBL] [Abstract][Full Text] [Related]
7. Fragment-Based Design, Synthesis, and Biological Evaluation of 1-Substituted-indole-2-carboxylic Acids as Selective Mcl-1 Inhibitors.
Wang Z; Xu W; Song T; Guo Z; Liu L; Fan Y; Wang A; Zhang Z
Arch Pharm (Weinheim); 2017 Jan; 350(1):. PubMed ID: 27911011
[TBL] [Abstract][Full Text] [Related]
8. Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.
Petros AM; Swann SL; Song D; Swinger K; Park C; Zhang H; Wendt MD; Kunzer AR; Souers AJ; Sun C
Bioorg Med Chem Lett; 2014 Mar; 24(6):1484-8. PubMed ID: 24582986
[TBL] [Abstract][Full Text] [Related]
9. Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
Tanaka Y; Aikawa K; Nishida G; Homma M; Sogabe S; Igaki S; Hayano Y; Sameshima T; Miyahisa I; Kawamoto T; Tawada M; Imai Y; Inazuka M; Cho N; Imaeda Y; Ishikawa T
J Med Chem; 2013 Dec; 56(23):9635-45. PubMed ID: 24215352
[TBL] [Abstract][Full Text] [Related]
10. SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
Rega MF; Wu B; Wei J; Zhang Z; Cellitti JF; Pellecchia M
J Med Chem; 2011 Sep; 54(17):6000-13. PubMed ID: 21797225
[TBL] [Abstract][Full Text] [Related]
11. Binding affinity of pro-apoptotic BH3 peptides for the anti-apoptotic Mcl-1 and A1 proteins: Molecular dynamics simulations of Mcl-1 and A1 in complex with six different BH3 peptides.
Modi V; Sankararamakrishnan R
J Mol Graph Model; 2017 May; 73():115-128. PubMed ID: 28279820
[TBL] [Abstract][Full Text] [Related]
12. Discovery and structure-activity relationship studies of novel Bcl-2/Mcl-1 dual inhibitors with indole scaffold.
Zhang Z; Hou L; Bai L; Pei J; Zhao S; Luan S; Liu D; Huang M; Zhao L
Bioorg Chem; 2022 Aug; 125():105845. PubMed ID: 35512494
[TBL] [Abstract][Full Text] [Related]
13. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).
Leverson JD; Zhang H; Chen J; Tahir SK; Phillips DC; Xue J; Nimmer P; Jin S; Smith M; Xiao Y; Kovar P; Tanaka A; Bruncko M; Sheppard GS; Wang L; Gierke S; Kategaya L; Anderson DJ; Wong C; Eastham-Anderson J; Ludlam MJ; Sampath D; Fairbrother WJ; Wertz I; Rosenberg SH; Tse C; Elmore SW; Souers AJ
Cell Death Dis; 2015 Jan; 6(1):e1590. PubMed ID: 25590800
[TBL] [Abstract][Full Text] [Related]
14. Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.
Luan S; Ge Q; Chen Y; Dai M; Yang J; Li K; Liu D; Zhao L
Bioorg Med Chem Lett; 2017 May; 27(9):1943-1948. PubMed ID: 28343875
[TBL] [Abstract][Full Text] [Related]
15. Recent Advances in Cancer Drug Development: Targeting Induced Myeloid Cell Leukemia-1 (Mcl-1) Differentiation Protein.
Abid M; Sonawane YA; Contreras JI; Rana S; Natarajan A
Curr Med Chem; 2017; 24(40):4488-4514. PubMed ID: 28901269
[TBL] [Abstract][Full Text] [Related]
16. 1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation.
Xu G; Liu T; Zhou Y; Yang X; Fang H
Bioorg Med Chem; 2017 Oct; 25(20):5548-5556. PubMed ID: 28866374
[TBL] [Abstract][Full Text] [Related]
17. 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.
Abulwerdi FA; Liao C; Mady AS; Gavin J; Shen C; Cierpicki T; Stuckey JA; Showalter HD; Nikolovska-Coleska Z
J Med Chem; 2014 May; 57(10):4111-33. PubMed ID: 24749893
[TBL] [Abstract][Full Text] [Related]
18. Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.
Li R; Cheng C; Balasis ME; Liu Y; Garner TP; Daniel KG; Li J; Qin Y; Gavathiotis E; Sebti SM
Eur J Med Chem; 2015 Jan; 90():315-331. PubMed ID: 25437618
[TBL] [Abstract][Full Text] [Related]
19. Evaluation and critical assessment of putative MCL-1 inhibitors.
Varadarajan S; Vogler M; Butterworth M; Dinsdale D; Walensky LD; Cohen GM
Cell Death Differ; 2013 Nov; 20(11):1475-84. PubMed ID: 23832116
[TBL] [Abstract][Full Text] [Related]
20. Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice.
Anstee NS; Bilardi RA; Ng AP; Xu Z; Robati M; Vandenberg CJ; Cory S
Cell Death Differ; 2019 Jul; 26(7):1316-1331. PubMed ID: 30470795
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
