335 related articles for article (PubMed ID: 26891837)
1. Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.
Alberca LN; Sbaraglini ML; Balcazar D; Fraccaroli L; Carrillo C; Medeiros A; Benitez D; Comini M; Talevi A
J Comput Aided Mol Des; 2016 Apr; 30(4):305-21. PubMed ID: 26891837
[TBL] [Abstract][Full Text] [Related]
2. Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.
Seguel V; Castro L; Reigada C; Cortes L; Díaz MV; Miranda MR; Pereira CA; Lapier M; Campos-Estrada C; Morello A; Kemmerling U; Maya JD; López-Muñoz R
Exp Parasitol; 2016 Dec; 171():23-32. PubMed ID: 27729250
[TBL] [Abstract][Full Text] [Related]
3. Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids.
Benítez D; Medeiros A; Fiestas L; Panozzo-Zenere EA; Maiwald F; Prousis KC; Roussaki M; Calogeropoulou T; Detsi A; Jaeger T; Šarlauskas J; Peterlin Mašič L; Kunick C; Labadie GR; Flohé L; Comini MA
PLoS Negl Trop Dis; 2016 Apr; 10(4):e0004617. PubMed ID: 27070550
[TBL] [Abstract][Full Text] [Related]
4. Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
Ariyanayagam MR; Oza SL; Mehlert A; Fairlamb AH
J Biol Chem; 2003 Jul; 278(30):27612-9. PubMed ID: 12750367
[TBL] [Abstract][Full Text] [Related]
5. Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi.
Mesías AC; Sasoni N; Arias DG; Pérez Brandán C; Orban OCF; Kunick C; Robello C; Comini MA; Garg NJ; Zago MP
Free Radic Biol Med; 2019 Jan; 130():23-34. PubMed ID: 30359758
[TBL] [Abstract][Full Text] [Related]
6. Genetic and chemical analyses reveal that trypanothione synthetase but not glutathionylspermidine synthetase is essential for Leishmania infantum.
Sousa AF; Gomes-Alves AG; Benítez D; Comini MA; Flohé L; Jaeger T; Passos J; Stuhlmann F; Tomás AM; Castro H
Free Radic Biol Med; 2014 Aug; 73():229-38. PubMed ID: 24853758
[TBL] [Abstract][Full Text] [Related]
7. Trypanosoma cruzi Polyamine Transporter: Its Role on Parasite Growth and Survival Under Stress Conditions.
Reigada C; Sayé M; Vera EV; Balcazar D; Fraccaroli L; Carrillo C; Miranda MR; Pereira CA
J Membr Biol; 2016 Aug; 249(4):475-81. PubMed ID: 26983938
[TBL] [Abstract][Full Text] [Related]
8. Targeting polyamine transport in Trypanosoma cruzi.
Reigada C; Phanstiel O; Miranda MR; Pereira CA
Eur J Med Chem; 2018 Mar; 147():1-6. PubMed ID: 29421567
[TBL] [Abstract][Full Text] [Related]
9. Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi.
Díaz MV; Miranda MR; Campos-Estrada C; Reigada C; Maya JD; Pereira CA; López-Muñoz R
Acta Trop; 2014 Jun; 134():1-9. PubMed ID: 24560964
[TBL] [Abstract][Full Text] [Related]
10. Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening.
Benítez D; Franco J; Sardi F; Leyva A; Durán R; Choi G; Yang G; Kim T; Kim N; Heo J; Kim K; Lee H; Choi I; Radu C; Shum D; No JH; Comini MA
J Enzyme Inhib Med Chem; 2022 Dec; 37(1):912-929. PubMed ID: 35306933
[TBL] [Abstract][Full Text] [Related]
11. Identification of cisapride as new inhibitor of putrescine uptake in Trypanosoma cruzi by combined ligand- and structure-based virtual screening.
Dietrich RC; Alberca LN; Ruiz MD; Palestro PH; Carrillo C; Talevi A; Gavernet L
Eur J Med Chem; 2018 Apr; 149():22-29. PubMed ID: 29494842
[TBL] [Abstract][Full Text] [Related]
12. In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei.
Rojas Vargas JA; López AG; Pérez Y; Cos P; Froeyen M
Parasitol Res; 2019 May; 118(5):1533-1548. PubMed ID: 30903349
[TBL] [Abstract][Full Text] [Related]
13. A combined ligand and target-based virtual screening strategy to repurpose drugs as putrescine uptake inhibitors with trypanocidal activity.
Llanos MA; Alberca LN; Ruiz MD; Sbaraglini ML; Miranda C; Pino-Martinez A; Fraccaroli L; Carrillo C; Alba Soto CD; Gavernet L; Talevi A
J Comput Aided Mol Des; 2023 Feb; 37(2):75-90. PubMed ID: 36494599
[TBL] [Abstract][Full Text] [Related]
14. Chagas disease: progress and new perspectives.
Sánchez-Sancho F; Campillo NE; Páez JA
Curr Med Chem; 2010; 17(5):423-52. PubMed ID: 20015038
[TBL] [Abstract][Full Text] [Related]
15. The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies.
Talevi A; Carrillo C; Comini M
Curr Med Chem; 2019; 26(36):6614-6635. PubMed ID: 30259812
[TBL] [Abstract][Full Text] [Related]
16. A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
Oza SL; Tetaud E; Ariyanayagam MR; Warnon SS; Fairlamb AH
J Biol Chem; 2002 Sep; 277(39):35853-61. PubMed ID: 12121990
[TBL] [Abstract][Full Text] [Related]
17. Drug Discovery for Paediatric Chagas Disease.
Thota S; Morel CM
Mini Rev Med Chem; 2018; 18(9):776-780. PubMed ID: 26202205
[TBL] [Abstract][Full Text] [Related]
18. Trypanothione Reductase and Superoxide Dismutase as Current Drug Targets for Trypanosoma cruzi: An Overview of Compounds with Activity against Chagas Disease.
Beltran-Hortelano I; Perez-Silanes S; Galiano S
Curr Med Chem; 2017 May; 24(11):1066-1138. PubMed ID: 28025938
[TBL] [Abstract][Full Text] [Related]
19. Targets and Patented Drugs for Chemotherapy of Chagas Disease in the Last 15 Years-Period.
Duschak VG
Recent Pat Antiinfect Drug Discov; 2016; 11(2):74-173. PubMed ID: 27784230
[TBL] [Abstract][Full Text] [Related]
20. Key proteins in the polyamine-trypanothione pathway as drug targets against Trypanosoma cruzi.
Maya JD; Salas CO; Aguilera-Venegas B; Diaz MV; López-Muñoz R
Curr Med Chem; 2014; 21(15):1757-71. PubMed ID: 24251576
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]