BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

241 related articles for article (PubMed ID: 26912170)

  • 1. 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.
    Leon J; Sakumi K; Castillo E; Sheng Z; Oka S; Nakabeppu Y
    Sci Rep; 2016 Feb; 6():22086. PubMed ID: 26912170
    [TBL] [Abstract][Full Text] [Related]  

  • 2. MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis.
    Oka S; Leon J; Sakumi K; Abolhassani N; Sheng Z; Tsuchimoto D; LaFerla FM; Nakabeppu Y
    Sci Rep; 2021 Mar; 11(1):5819. PubMed ID: 33758207
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.
    Sheng Z; Oka S; Tsuchimoto D; Abolhassani N; Nomaru H; Sakumi K; Yamada H; Nakabeppu Y
    J Clin Invest; 2012 Dec; 122(12):4344-61. PubMed ID: 23143307
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain.
    Abolhassani N; Leon J; Sheng Z; Oka S; Hamasaki H; Iwaki T; Nakabeppu Y
    Mech Ageing Dev; 2017 Jan; 161(Pt A):95-104. PubMed ID: 27233446
    [TBL] [Abstract][Full Text] [Related]  

  • 5. MTH1 as a nucleotide pool sanitizing enzyme: Friend or foe?
    Nakabeppu Y; Ohta E; Abolhassani N
    Free Radic Biol Med; 2017 Jun; 107():151-158. PubMed ID: 27833032
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Oxidative damage in nucleic acids and Parkinson's disease.
    Nakabeppu Y; Tsuchimoto D; Yamaguchi H; Sakumi K
    J Neurosci Res; 2007 Apr; 85(5):919-34. PubMed ID: 17279544
    [TBL] [Abstract][Full Text] [Related]  

  • 7. MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity.
    Kajitani K; Yamaguchi H; Dan Y; Furuichi M; Kang D; Nakabeppu Y
    J Neurosci; 2006 Feb; 26(6):1688-98. PubMed ID: 16467516
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the App
    Mizuno Y; Abolhassani N; Mazzei G; Saito T; Saido TC; Yamasaki R; Kira JI; Nakabeppu Y
    Neurosci Res; 2022 Apr; 177():118-134. PubMed ID: 34838904
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method.
    Ohno M; Oka S; Nakabeppu Y
    Methods Mol Biol; 2009; 554():199-212. PubMed ID: 19513676
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage.
    Oka S; Ohno M; Nakabeppu Y
    Methods Mol Biol; 2009; 554():251-64. PubMed ID: 19513679
    [TBL] [Abstract][Full Text] [Related]  

  • 11. MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    Yamaguchi H; Kajitani K; Dan Y; Furuichi M; Ohno M; Sakumi K; Kang D; Nakabeppu Y
    Cell Death Differ; 2006 Apr; 13(4):551-63. PubMed ID: 16273081
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mitochondrial maintenance under oxidative stress depends on mitochondrially localised α-OGG1.
    Lia D; Reyes A; de Melo Campos JTA; Piolot T; Baijer J; Radicella JP; Campalans A
    J Cell Sci; 2018 Jun; 131(12):. PubMed ID: 29848661
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.
    Sakumi K; Tominaga Y; Furuichi M; Xu P; Tsuzuki T; Sekiguchi M; Nakabeppu Y
    Cancer Res; 2003 Mar; 63(5):902-5. PubMed ID: 12615700
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.
    Ichikawa J; Tsuchimoto D; Oka S; Ohno M; Furuichi M; Sakumi K; Nakabeppu Y
    DNA Repair (Amst); 2008 Mar; 7(3):418-30. PubMed ID: 18155646
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.
    de Souza-Pinto NC; Eide L; Hogue BA; Thybo T; Stevnsner T; Seeberg E; Klungland A; Bohr VA
    Cancer Res; 2001 Jul; 61(14):5378-81. PubMed ID: 11454679
    [TBL] [Abstract][Full Text] [Related]  

  • 16. MTH1 inhibition synergizes with ROS-inducing agents to trigger cervical cancer cells undergoing parthanatos.
    Li C; Xue Y; Wu J; Zhang L; Yang T; Ai M; Han J; Zheng X; Wang R; Boldogh I; Ba X
    Biochim Biophys Acta Mol Basis Dis; 2024 Jun; 1870(5):167190. PubMed ID: 38657912
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity.
    Hashiguchi K; Stuart JA; de Souza-Pinto NC; Bohr VA
    Nucleic Acids Res; 2004; 32(18):5596-608. PubMed ID: 15494448
    [TBL] [Abstract][Full Text] [Related]  

  • 18. MTH1, an oxidized purine nucleoside triphosphatase, prevents the cytotoxicity and neurotoxicity of oxidized purine nucleotides.
    Nakabeppu Y; Kajitani K; Sakamoto K; Yamaguchi H; Tsuchimoto D
    DNA Repair (Amst); 2006 Jul; 5(7):761-72. PubMed ID: 16621731
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions.
    Liu D; Croteau DL; Souza-Pinto N; Pitta M; Tian J; Wu C; Jiang H; Mustafa K; Keijzers G; Bohr VA; Mattson MP
    J Cereb Blood Flow Metab; 2011 Feb; 31(2):680-92. PubMed ID: 20736962
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei.
    Nakabeppu Y; Tsuchimoto D; Ichinoe A; Ohno M; Ide Y; Hirano S; Yoshimura D; Tominaga Y; Furuichi M; Sakumi K
    Ann N Y Acad Sci; 2004 Apr; 1011():101-11. PubMed ID: 15126288
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.