BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

795 related articles for article (PubMed ID: 26915435)

  • 1. The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1.
    Genrich G; Kruppa M; Lenk L; Helm O; Broich A; Freitag-Wolf S; Röcken C; Sipos B; Schäfer H; Sebens S
    BMC Cancer; 2016 Feb; 16():155. PubMed ID: 26915435
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells.
    Arfmann-Knübel S; Struck B; Genrich G; Helm O; Sipos B; Sebens S; Schäfer H
    PLoS One; 2015; 10(7):e0132978. PubMed ID: 26226105
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling.
    Ungefroren H; Sebens S; Giehl K; Helm O; Groth S; Fändrich F; Röcken C; Sipos B; Lehnert H; Gieseler F
    Oncotarget; 2014 Jan; 5(1):277-90. PubMed ID: 24378395
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2.
    Kha ML; Hesse L; Deisinger F; Sipos B; Röcken C; Arlt A; Sebens S; Helm O; Schäfer H
    Oncogene; 2019 Feb; 38(9):1461-1476. PubMed ID: 30302023
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancer.
    Geismann C; Morscheck M; Koch D; Bergmann F; Ungefroren H; Arlt A; Tsao MS; Bachem MG; Altevogt P; Sipos B; Fölsch UR; Schäfer H; Müerköster SS
    Cancer Res; 2009 May; 69(10):4517-26. PubMed ID: 19435915
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Binding of the transcription factor Slug to the L1CAM promoter is essential for transforming growth factor-β1 (TGF-β)-induced L1CAM expression in human pancreatic ductal adenocarcinoma cells.
    Geismann C; Arlt A; Bauer I; Pfeifer M; Schirmer U; Altevogt P; Müerköster SS; Schäfer H
    Int J Oncol; 2011 Jan; 38(1):257-66. PubMed ID: 21109948
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells.
    Rahn S; Zimmermann V; Viol F; Knaack H; Stemmer K; Peters L; Lenk L; Ungefroren H; Saur D; Schäfer H; Helm O; Sebens S
    Cancer Lett; 2018 Feb; 415():129-150. PubMed ID: 29222037
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Negative control of TRAIL-R1 signaling by transforming growth factor β1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1.
    Radke DI; Ungefroren H; Helm O; Voigt S; Alp G; Braun H; Hübner S; Dilchert J; Sebens S; Adam D; Kalthoff H; Trauzold A
    Cell Signal; 2016 Nov; 28(11):1652-62. PubMed ID: 27492861
    [TBL] [Abstract][Full Text] [Related]  

  • 9. NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.
    Chen NM; Singh G; Koenig A; Liou GY; Storz P; Zhang JS; Regul L; Nagarajan S; Kühnemuth B; Johnsen SA; Hebrok M; Siveke J; Billadeau DD; Ellenrieder V; Hessmann E
    Gastroenterology; 2015 May; 148(5):1024-1034.e9. PubMed ID: 25623042
    [TBL] [Abstract][Full Text] [Related]  

  • 10. A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.
    Inagawa Y; Yamada K; Yugawa T; Ohno S; Hiraoka N; Esaki M; Shibata T; Aoki K; Saya H; Kiyono T
    Carcinogenesis; 2014 Aug; 35(8):1840-6. PubMed ID: 24858378
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action.
    Bartscht T; Rosien B; Rades D; Kaufmann R; Biersack H; Lehnert H; Gieseler F; Ungefroren H
    Mol Cancer; 2015 Nov; 14():199. PubMed ID: 26588899
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis.
    Qian J; Niu J; Li M; Chiao PJ; Tsao MS
    Cancer Res; 2005 Jun; 65(12):5045-53. PubMed ID: 15958547
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer.
    Su HT; Weng CC; Hsiao PJ; Chen LH; Kuo TL; Chen YW; Kuo KK; Cheng KH
    Mol Cancer Res; 2013 Jul; 11(7):768-79. PubMed ID: 23552743
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1.
    Ottaviano AJ; Sun L; Ananthanarayanan V; Munshi HG
    Cancer Res; 2006 Jul; 66(14):7032-40. PubMed ID: 16849548
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Differential roles of Src in transforming growth factor-ß regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells.
    Ungefroren H; Sebens S; Groth S; Gieseler F; Fändrich F
    Int J Oncol; 2011 Mar; 38(3):797-805. PubMed ID: 21225226
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1.
    Ungefroren H; Groth S; Sebens S; Lehnert H; Gieseler F; Fändrich F
    Mol Cancer; 2011 May; 10():67. PubMed ID: 21624123
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells.
    Liang C; Shi S; Liu M; Qin Y; Meng Q; Hua J; Ji S; Zhang Y; Yang J; Xu J; Ni Q; Li M; Yu X
    Cancer Res; 2019 Jan; 79(1):133-145. PubMed ID: 30355620
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity.
    Arlt A; Sebens S; Krebs S; Geismann C; Grossmann M; Kruse ML; Schreiber S; Schäfer H
    Oncogene; 2013 Oct; 32(40):4825-35. PubMed ID: 23108405
    [TBL] [Abstract][Full Text] [Related]  

  • 19. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
    Nolan-Stevaux O; Lau J; Truitt ML; Chu GC; Hebrok M; Fernández-Zapico ME; Hanahan D
    Genes Dev; 2009 Jan; 23(1):24-36. PubMed ID: 19136624
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification.
    Wu YS; Looi CY; Subramaniam KS; Masamune A; Chung I
    Oncotarget; 2016 Jun; 7(24):36719-36732. PubMed ID: 27167341
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 40.