BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

420 related articles for article (PubMed ID: 26935067)

  • 21. Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
    Huerta C; Jiang X; Trevino I; Bender CF; Ferguson DA; Probst B; Swinger KK; Stoll VS; Thomas PJ; Dulubova I; Visnick M; Wigley WC
    Biochim Biophys Acta; 2016 Nov; 1860(11 Pt A):2537-2552. PubMed ID: 27474998
    [TBL] [Abstract][Full Text] [Related]  

  • 22. A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity.
    Tran KT; Pallesen JS; Solbak SMØ; Narayanan D; Baig A; Zang J; Aguayo-Orozco A; Carmona RMC; Garcia AD; Bach A
    J Med Chem; 2019 Sep; 62(17):8028-8052. PubMed ID: 31411465
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction.
    Wells G
    Biochem Soc Trans; 2015 Aug; 43(4):674-9. PubMed ID: 26551711
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction.
    Colarusso S; De Simone D; Frattarelli T; Andreini M; Cerretani M; Missineo A; Moretti D; Tambone S; Kempf G; Augustin M; Steinbacher S; Munoz-Sanjuan I; Park L; Summa V; Tomei L; Bresciani A; Dominguez C; Toledo-Sherman L; Bianchi E
    Bioorg Med Chem; 2020 Nov; 28(21):115738. PubMed ID: 33065433
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Accumulation of phosphorylated p62 is associated with NF-E2-related factor 2 activation in hepatocellular carcinoma.
    Shimizu T; Inoue K; Hachiya H; Shibuya N; Aoki T; Kubota K
    J Hepatobiliary Pancreat Sci; 2016 Aug; 23(8):467-71. PubMed ID: 27246794
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions.
    Jiang ZY; Lu MC; You QD
    J Med Chem; 2016 Dec; 59(24):10837-10858. PubMed ID: 27690435
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface.
    Bhakkiyalakshmi E; Dineshkumar K; Karthik S; Sireesh D; Hopper W; Paulmurugan R; Ramkumar KM
    Bioorg Med Chem; 2016 Aug; 24(16):3378-86. PubMed ID: 27312421
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1.
    Unni S; Deshmukh P; Krishnappa G; Kommu P; Padmanabhan B
    FEBS J; 2021 Mar; 288(5):1599-1613. PubMed ID: 32672401
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Molecular basis for the disruption of Keap1-Nrf2 interaction via Hinge & Latch mechanism.
    Horie Y; Suzuki T; Inoue J; Iso T; Wells G; Moore TW; Mizushima T; Dinkova-Kostova AT; Kasai T; Kamei T; Koshiba S; Yamamoto M
    Commun Biol; 2021 May; 4(1):576. PubMed ID: 33990683
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Rational cyclization-based minimization of entropy penalty upon the binding of Nrf2-derived linear peptides to Keap1: A new strategy to improve therapeutic peptide activity against sepsis.
    Chen K; Huang L; Shen B
    Biophys Chem; 2019 Jan; 244():22-28. PubMed ID: 30465941
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Development of a steady-state FRET-based assay to identify inhibitors of the Keap1-Nrf2 protein-protein interaction.
    Schaap M; Hancock R; Wilderspin A; Wells G
    Protein Sci; 2013 Dec; 22(12):1812-9. PubMed ID: 24130096
    [TBL] [Abstract][Full Text] [Related]  

  • 32. [Hit-to-Lead in Academia: Discovery of a Protein-Protein Interaction Inhibitor of Keap1-Nrf2].
    Yasuda D; Obata R; Takahashi K; Ohe T; Mashino T
    Yakugaku Zasshi; 2018; 138(8):1059-1065. PubMed ID: 30068847
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Perfluoroarene-based peptide macrocycles that inhibit the Nrf2/Keap1 interaction.
    Steel RJ; O'Connell MA; Searcey M
    Bioorg Med Chem Lett; 2018 Sep; 28(16):2728-2731. PubMed ID: 29534931
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.
    Ishimura R; Tanaka K; Komatsu M
    FEBS Lett; 2014 Mar; 588(5):822-8. PubMed ID: 24492006
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Discovery of a Kelch-like ECH-associated protein 1-inhibitory tetrapeptide and its structural characterization.
    Sogabe S; Sakamoto K; Kamada Y; Kadotani A; Fukuda Y; Sakamoto JI
    Biochem Biophys Res Commun; 2017 May; 486(3):620-625. PubMed ID: 28315327
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Licochalcone A activates Keap1-Nrf2 signaling to suppress arthritis via phosphorylation of p62 at serine 349.
    Su X; Li T; Liu Z; Huang Q; Liao K; Ren R; Lu L; Qi X; Wang M; Chen J; Zhou H; Leung EL; Pan H; Liu J; Wang H; Huang L; Liu L
    Free Radic Biol Med; 2018 Feb; 115():471-483. PubMed ID: 29233793
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Novel target for treating Alzheimer's Diseases: Crosstalk between the Nrf2 pathway and autophagy.
    Zhang W; Feng C; Jiang H
    Ageing Res Rev; 2021 Jan; 65():101207. PubMed ID: 33144123
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor.
    Yasuda D; Yuasa A; Obata R; Nakajima M; Takahashi K; Ohe T; Ichimura Y; Komatsu M; Yamamoto M; Imamura R; Kojima H; Okabe T; Nagano T; Mashino T
    Bioorg Med Chem Lett; 2017 Nov; 27(22):5006-5009. PubMed ID: 29037947
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery of Keap1-Nrf2 small-molecule inhibitors from phytochemicals based on molecular docking.
    Li M; Huang W; Jie F; Wang M; Zhong Y; Chen Q; Lu B
    Food Chem Toxicol; 2019 Nov; 133():110758. PubMed ID: 31412289
    [TBL] [Abstract][Full Text] [Related]  

  • 40. PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.
    Park JS; Kang DH; Lee DH; Bae SH
    Biochem Biophys Res Commun; 2015 Oct; 466(3):499-504. PubMed ID: 26381178
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 21.