These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. Sharlow ER; Lyda TA; Dodson HC; Mustata G; Morris MT; Leimgruber SS; Lee KH; Kashiwada Y; Close D; Lazo JS; Morris JC PLoS Negl Trop Dis; 2010 Apr; 4(4):e659. PubMed ID: 20405000 [TBL] [Abstract][Full Text] [Related]
5. From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules. Woodland A; Grimaldi R; Luksch T; Cleghorn LA; Ojo KK; Van Voorhis WC; Brenk R; Frearson JA; Gilbert IH; Wyatt PG ChemMedChem; 2013 Jul; 8(7):1127-37. PubMed ID: 23776181 [TBL] [Abstract][Full Text] [Related]
6. Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy. Ojo KK; Gillespie JR; Riechers AJ; Napuli AJ; Verlinde CL; Buckner FS; Gelb MH; Domostoj MM; Wells SJ; Scheer A; Wells TN; Van Voorhis WC Antimicrob Agents Chemother; 2008 Oct; 52(10):3710-7. PubMed ID: 18644955 [TBL] [Abstract][Full Text] [Related]
7. Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African Trypanosome. Guyett PJ; Xia S; Swinney DC; Pollastri MP; Mensa-Wilmot K ACS Infect Dis; 2016 Jul; 2(7):518-28. PubMed ID: 27626104 [TBL] [Abstract][Full Text] [Related]
8. Trypanosome alternative oxidase, a potential therapeutic target for sleeping sickness, is conserved among Trypanosoma brucei subspecies. Nakamura K; Fujioka S; Fukumoto S; Inoue N; Sakamoto K; Hirata H; Kido Y; Yabu Y; Suzuki T; Watanabe Y; Saimoto H; Akiyama H; Kita K Parasitol Int; 2010 Dec; 59(4):560-4. PubMed ID: 20688188 [TBL] [Abstract][Full Text] [Related]
9. Design and synthesis of N-(3-sulfamoylphenyl)amides as Trypanosoma brucei leucyl-tRNA synthetase inhibitors. Li Z; Xin W; Wang Q; Zhu M; Zhou H Eur J Med Chem; 2021 May; 217():113319. PubMed ID: 33725631 [TBL] [Abstract][Full Text] [Related]
10. Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay. Volkov OA; Cosner CC; Brockway AJ; Kramer M; Booker M; Zhong S; Ketcherside A; Wei S; Longgood J; McCoy M; Richardson TE; Wring SA; Peel M; Klinger JD; Posner BA; De Brabander JK; Phillips MA ACS Infect Dis; 2017 Jul; 3(7):512-526. PubMed ID: 28350440 [TBL] [Abstract][Full Text] [Related]
11. Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. Pedró-Rosa L; Buckner FS; Ranade RM; Eberhart C; Madoux F; Gillespie JR; Koh CY; Brown S; Lohse J; Verlinde CL; Fan E; Bannister T; Scampavia L; Hol WG; Spicer T; Hodder P J Biomol Screen; 2015 Jan; 20(1):122-30. PubMed ID: 25163684 [TBL] [Abstract][Full Text] [Related]
12. Structure-Based Virtual Screening and Biochemical Evaluation for the Identification of Novel Trypanosoma brucei Aldolase Inhibitors. Ferreira LLG; Ferreira RS; Palomino DL; Andricopulo AD Curr Top Med Chem; 2018; 18(5):397-405. PubMed ID: 29701141 [TBL] [Abstract][Full Text] [Related]
13. Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. Pizarro JC; Hills T; Senisterra G; Wernimont AK; Mackenzie C; Norcross NR; Ferguson MA; Wyatt PG; Gilbert IH; Hui R PLoS Negl Trop Dis; 2013; 7(10):e2492. PubMed ID: 24147171 [TBL] [Abstract][Full Text] [Related]
14. Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign. Sykes ML; Baell JB; Kaiser M; Chatelain E; Moawad SR; Ganame D; Ioset JR; Avery VM PLoS Negl Trop Dis; 2012; 6(11):e1896. PubMed ID: 23209849 [TBL] [Abstract][Full Text] [Related]
15. Enzymatic Targets in Trypanosoma brucei. Scotti L; Mendonça FJ; da Silva MS; Scotti MT Curr Protein Pept Sci; 2016; 17(3):243-59. PubMed ID: 26983886 [TBL] [Abstract][Full Text] [Related]
16. Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase. Volkov OA; Brockway AJ; Wring SA; Peel M; Chen Z; Phillips MA; De Brabander JK J Med Chem; 2018 Feb; 61(3):1182-1203. PubMed ID: 29271204 [TBL] [Abstract][Full Text] [Related]
17. Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor. Valenciano AL; Ramsey AC; Santos WL; Mackey ZB Bioorg Med Chem; 2016 Oct; 24(19):4647-4651. PubMed ID: 27519462 [TBL] [Abstract][Full Text] [Related]
18. The design and synthesis of potent and selective inhibitors of Trypanosoma brucei glycogen synthase kinase 3 for the treatment of human african trypanosomiasis. Urich R; Grimaldi R; Luksch T; Frearson JA; Brenk R; Wyatt PG J Med Chem; 2014 Sep; 57(18):7536-49. PubMed ID: 25198388 [TBL] [Abstract][Full Text] [Related]
19. In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase. Herrmann FC; Lenz M; Jose J; Kaiser M; Brun R; Schmidt TJ Molecules; 2015 Sep; 20(9):16154-69. PubMed ID: 26404225 [TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors. Xin W; Li Z; Wang Q; Du J; Zhu M; Zhou H Eur J Med Chem; 2020 Jan; 185():111827. PubMed ID: 31732256 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]