BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

133 related articles for article (PubMed ID: 26943489)

  • 1. Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K).
    Van Dort ME; Hong H; Wang H; Nino CA; Lombardi RL; Blanks AE; Galbán S; Ross BD
    J Med Chem; 2016 Mar; 59(6):2512-22. PubMed ID: 26943489
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor, SMK-17.
    Kiga M; Tanzawa F; Iwasaki S; Inaba F; Fujiwara K; Iwadare H; Echigo T; Nakamura Y; Shibata T; Suzuki K; Yasumatsu I; Nakayama A; Sasazawa Y; Tashiro E; Imoto M; Kurakata S
    Anticancer Drugs; 2012 Jan; 23(1):119-30. PubMed ID: 22008853
    [TBL] [Abstract][Full Text] [Related]  

  • 3. MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma.
    Mohan S; Vander Broek R; Shah S; Eytan DF; Pierce ML; Carlson SG; Coupar JF; Zhang J; Cheng H; Chen Z; Van Waes C
    Clin Cancer Res; 2015 Sep; 21(17):3946-56. PubMed ID: 25977343
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural effects of morpholine replacement in ZSTK474 on Class I PI3K isoform inhibition: Development of novel MEK/PI3K bifunctional inhibitors.
    Van Dort ME; Jang Y; Bonham CA; Heist K; Palagama DSW; McDonald L; Zhang EZ; Chenevert TL; Luker GD; Ross BD
    Eur J Med Chem; 2022 Feb; 229():113996. PubMed ID: 34802837
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.
    Van Dort ME; Galbán S; Wang H; Sebolt-Leopold J; Whitehead C; Hong H; Rehemtulla A; Ross BD
    Bioorg Med Chem; 2015 Apr; 23(7):1386-94. PubMed ID: 25766633
    [TBL] [Abstract][Full Text] [Related]  

  • 6. MEK inhibitors against MET-amplified non-small cell lung cancer.
    Chiba M; Togashi Y; Tomida S; Mizuuchi H; Nakamura Y; Banno E; Hayashi H; Terashima M; De Velasco MA; Sakai K; Fujita Y; Mitsudomi T; Nishio K
    Int J Oncol; 2016 Dec; 49(6):2236-2244. PubMed ID: 27748834
    [TBL] [Abstract][Full Text] [Related]  

  • 7. [Treatment of triple negative breast cancer cells with combination of mTOR1/2 inhibitor AZD8055 and MEK1/2 inhibitor PD0325901].
    Nan XY; Wu Y; Zhang LH; Yang ZJ
    Yao Xue Xue Bao; 2016 Oct; 51(10):1551-7. PubMed ID: 29932599
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors.
    Sheppard KE; Cullinane C; Hannan KM; Wall M; Chan J; Barber F; Foo J; Cameron D; Neilsen A; Ng P; Ellul J; Kleinschmidt M; Kinross KM; Bowtell DD; Christensen JG; Hicks RJ; Johnstone RW; McArthur GA; Hannan RD; Phillips WA; Pearson RB
    Eur J Cancer; 2013 Dec; 49(18):3936-44. PubMed ID: 24011934
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A novel PI3K inhibitor iMDK suppresses non-small cell lung Cancer cooperatively with A MEK inhibitor.
    Ishida N; Fukazawa T; Maeda Y; Yamatsuji T; Kato K; Matsumoto K; Shimo T; Takigawa N; Whitsett JA; Naomoto Y
    Exp Cell Res; 2015 Jul; 335(2):197-206. PubMed ID: 25839409
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer.
    Pitts TM; Newton TP; Bradshaw-Pierce EL; Addison R; Arcaroli JJ; Klauck PJ; Bagby SM; Hyatt SL; Purkey A; Tentler JJ; Tan AC; Messersmith WA; Eckhardt SG; Leong S
    PLoS One; 2014; 9(11):e113037. PubMed ID: 25401499
    [TBL] [Abstract][Full Text] [Related]  

  • 11. MEK inhibitor for gastric cancer with MEK1 gene mutations.
    Sogabe S; Togashi Y; Kato H; Kogita A; Mizukami T; Sakamoto Y; Banno E; Terashima M; Hayashi H; de Velasco MA; Sakai K; Fujita Y; Tomida S; Yasuda T; Takeyama Y; Okuno K; Nishio K
    Mol Cancer Ther; 2014 Dec; 13(12):3098-106. PubMed ID: 25253779
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification and characterization of a novel chemotype MEK inhibitor able to alter the phosphorylation state of MEK1/2.
    Yoshida T; Kakegawa J; Yamaguchi T; Hantani Y; Okajima N; Sakai T; Watanabe Y; Nakamura M
    Oncotarget; 2012 Dec; 3(12):1533-45. PubMed ID: 23237773
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.
    Mallon R; Feldberg L; Kim S; Collins K; Wojciechowicz D; Kohler C; Kovacs D; Discafani C; Zhang N; Wu B; Floyd B; Powell D; Berger D
    Mol Cancer Ther; 2004 Jun; 3(6):755-62. PubMed ID: 15210862
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Modular Assembly of Allosteric MEK Inhibitor Structural Elements Unravels Potency and Feedback-Modulation Handles.
    Hartung IV; Pühler F; Neuhaus R; Scholz A; Siemeister G; Geisler J; Hillig RC; von Ahsen O; Hitchcock M
    ChemMedChem; 2015 Dec; 10(12):2004-13. PubMed ID: 26541480
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Patient-derived xenografts reveal limits to PI3K/mTOR- and MEK-mediated inhibition of bladder cancer.
    Cirone P; Andresen CJ; Eswaraka JR; Lappin PB; Bagi CM
    Cancer Chemother Pharmacol; 2014 Mar; 73(3):525-38. PubMed ID: 24442130
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.
    Hoeflich KP; O'Brien C; Boyd Z; Cavet G; Guerrero S; Jung K; Januario T; Savage H; Punnoose E; Truong T; Zhou W; Berry L; Murray L; Amler L; Belvin M; Friedman LS; Lackner MR
    Clin Cancer Res; 2009 Jul; 15(14):4649-64. PubMed ID: 19567590
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K.
    Kim JE; Lee DE; Lee KW; Son JE; Seo SK; Li J; Jung SK; Heo YS; Mottamal M; Bode AM; Dong Z; Lee HJ
    Cancer Prev Res (Phila); 2011 Apr; 4(4):582-91. PubMed ID: 21330379
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy.
    Yu K; Toral-Barza L; Shi C; Zhang WG; Zask A
    Cancer Biol Ther; 2008 Feb; 7(2):307-15. PubMed ID: 18059185
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice.
    Haagensen EJ; Thomas HD; Wilson I; Harnor SJ; Payne SL; Rennison T; Smith KM; Maxwell RJ; Newell DR
    PLoS One; 2013; 8(12):e81763. PubMed ID: 24339963
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Noninvasive imaging of cell proliferation following mitogenic extracellular kinase inhibition by PD0325901.
    Leyton J; Smith G; Lees M; Perumal M; Nguyen QD; Aigbirhio FI; Golovko O; He Q; Workman P; Aboagye EO
    Mol Cancer Ther; 2008 Sep; 7(9):3112-21. PubMed ID: 18790789
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.