147 related articles for article (PubMed ID: 26950250)
21. Inducible tyrosine kinase inhibitors: a review of the patent literature (2010 - 2013).
Norman P
Expert Opin Ther Pat; 2014 Sep; 24(9):979-91. PubMed ID: 24990480
[TBL] [Abstract][Full Text] [Related]
22. Analyzing GPCR-Ligand Interactions with the Fragment Molecular Orbital (FMO) Method.
Heifetz A; James T; Southey M; Morao I; Fedorov DG; Bodkin MJ; Townsend-Nicholson A
Methods Mol Biol; 2020; 2114():163-175. PubMed ID: 32016893
[TBL] [Abstract][Full Text] [Related]
23. Inhibition of the IL-2-inducible tyrosine kinase (Itk) activity: a new concept for the therapy of inflammatory skin diseases.
von Bonin A; Rausch A; Mengel A; Hitchcock M; Krüger M; von Ahsen O; Merz C; Röse L; Stock C; Martin SF; Leder G; Döcke WD; Asadullah K; Zügel U
Exp Dermatol; 2011 Jan; 20(1):41-7. PubMed ID: 21158938
[TBL] [Abstract][Full Text] [Related]
24. Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.
Laufer R; Ng G; Liu Y; Patel NK; Edwards LG; Lang Y; Li SW; Feher M; Awrey DE; Leung G; Beletskaya I; Plotnikova O; Mason JM; Hodgson R; Wei X; Mao G; Luo X; Huang P; Green E; Kiarash R; Lin DC; Harris-Brandts M; Ban F; Nadeem V; Mak TW; Pan GJ; Qiu W; Chirgadze NY; Pauls HW
Bioorg Med Chem; 2014 Sep; 22(17):4968-97. PubMed ID: 25043312
[TBL] [Abstract][Full Text] [Related]
25. Probing the ATP-Binding Pocket of Protein Kinase DYRK1A with Benzothiazole Fragment Molecules.
Rothweiler U; Stensen W; Brandsdal BO; Isaksson J; Leeson FA; Engh RA; Svendsen JS
J Med Chem; 2016 Nov; 59(21):9814-9824. PubMed ID: 27736065
[TBL] [Abstract][Full Text] [Related]
26. Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs.
Lee SJ; Choi JS; Han BG; Kim HS; Song HJ; Lee J; Nam S; Goh SH; Kim JH; Koh JS; Lee BI
FEBS J; 2016 Oct; 283(19):3613-3625. PubMed ID: 27504936
[TBL] [Abstract][Full Text] [Related]
27. A three-dimensional pharmacophore modelling of ITK inhibitors and virtual screening for novel inhibitors.
Bagga V; Silakari O; Ghorela VS; Bahia MS; Rambabu G; Sarma J
SAR QSAR Environ Res; 2011 Mar; 22(1-2):171-90. PubMed ID: 21391146
[TBL] [Abstract][Full Text] [Related]
28. Crystal structures of IL-2-inducible T cell kinase complexed with inhibitors: insights into rational drug design and activity regulation.
Kutach AK; Villaseñor AG; Lam D; Belunis C; Janson C; Lok S; Hong LN; Liu CM; Deval J; Novak TJ; Barnett JW; Chu W; Shaw D; Kuglstatter A
Chem Biol Drug Des; 2010 Aug; 76(2):154-63. PubMed ID: 20545945
[TBL] [Abstract][Full Text] [Related]
29. Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis.
Kim KH; Maderna A; Schnute ME; Hegen M; Mohan S; Miyashiro J; Lin L; Li E; Keegan S; Lussier J; Wrocklage C; Nickerson-Nutter CL; Wittwer AJ; Soutter H; Caspers N; Han S; Kurumbail R; Dunussi-Joannopoulos K; Douhan J; Wissner A
Bioorg Med Chem Lett; 2011 Nov; 21(21):6258-63. PubMed ID: 21958547
[TBL] [Abstract][Full Text] [Related]
30. 3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6.
Fraley ME; Steen JT; Brnardic EJ; Arrington KL; Spencer KL; Hanney BA; Kim Y; Hartman GD; Stirdivant SM; Drakas BA; Rickert K; Walsh ES; Hamilton K; Buser CA; Hardwick J; Tao W; Beck SC; Mao X; Lobell RB; Sepp-Lorenzino L; Yan Y; Ikuta M; Munshi SK; Kuo LC; Kreatsoulas C
Bioorg Med Chem Lett; 2006 Dec; 16(23):6049-53. PubMed ID: 16978863
[TBL] [Abstract][Full Text] [Related]
31. A FLIPR-based assay to assess potency and selectivity of inhibitors of the TEC family kinases Btk and Itk.
Douhan J; Miyashiro JS; Zhou X; Cole DC; Wu PW; Collins M; Dunussi-Joannopoulos K
Assay Drug Dev Technol; 2007 Dec; 5(6):751-8. PubMed ID: 18181691
[TBL] [Abstract][Full Text] [Related]
32. QM methods in structure based design: utility in probing protein-ligand interactions.
Gleeson MP; Hannongbua S; Gleeson D
J Mol Graph Model; 2010 Dec; 29(4):507-17. PubMed ID: 21075029
[TBL] [Abstract][Full Text] [Related]
33. Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis.
Lechner KS; Neurath MF; Weigmann B
J Mol Med (Berl); 2020 Oct; 98(10):1385-1395. PubMed ID: 32808093
[TBL] [Abstract][Full Text] [Related]
34. The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.
Liu Y; Lang Y; Patel NK; Ng G; Laufer R; Li SW; Edwards L; Forrest B; Sampson PB; Feher M; Ban F; Awrey DE; Beletskaya I; Mao G; Hodgson R; Plotnikova O; Qiu W; Chirgadze NY; Mason JM; Wei X; Lin DC; Che Y; Kiarash R; Madeira B; Fletcher GC; Mak TW; Bray MR; Pauls HW
J Med Chem; 2015 Apr; 58(8):3366-92. PubMed ID: 25763473
[TBL] [Abstract][Full Text] [Related]
35. Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.
Gavara L; Suchaud V; Nauton L; Théry V; Anizon F; Moreau P
Bioorg Med Chem Lett; 2013 Apr; 23(8):2298-301. PubMed ID: 23499503
[TBL] [Abstract][Full Text] [Related]
36. QM/MM as a tool in fragment based drug discovery. A cross-docking, rescoring study of kinase inhibitors.
Gleeson MP; Gleeson D
J Chem Inf Model; 2009 Jun; 49(6):1437-48. PubMed ID: 19459698
[TBL] [Abstract][Full Text] [Related]
37. Molecular modeling study of checkpoint kinase 1 inhibitors by multiple docking strategies and prime/MM-GBSA calculation.
Du J; Sun H; Xi L; Li J; Yang Y; Liu H; Yao X
J Comput Chem; 2011 Oct; 32(13):2800-9. PubMed ID: 21717478
[TBL] [Abstract][Full Text] [Related]
38. Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors.
Kashem MA; Nelson RM; Yingling JD; Pullen SS; Prokopowicz AS; Jones JW; Wolak JP; Rogers GR; Morelock MM; Snow RJ; Homon CA; Jakes S
J Biomol Screen; 2007 Feb; 12(1):70-83. PubMed ID: 17166826
[TBL] [Abstract][Full Text] [Related]
39. Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk).
Moriarty KJ; Takahashi H; Pullen SS; Khine HH; Sallati RH; Raymond EL; Woska JR; Jeanfavre DD; Roth GP; Winters MP; Qiao L; Ryan D; DesJarlais R; Robinson D; Wilson M; Bobko M; Cook BN; Lo HY; Nemoto PA; Kashem MA; Wolak JP; White A; Magolda RL; Tomczuk B
Bioorg Med Chem Lett; 2008 Oct; 18(20):5545-9. PubMed ID: 18819799
[TBL] [Abstract][Full Text] [Related]
40. X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome.
Kallen J; Bergsdorf C; Arnaud B; Bernhard M; Brichet M; Cobos-Correa A; Elhajouji A; Freuler F; Galimberti I; Guibourdenche C; Haenni S; Holzinger S; Hunziker J; Izaac A; Kaufmann M; Leder L; Martus HJ; von Matt P; Polyakov V; Roethlisberger P; Roma G; Stiefl N; Uteng M; Lerchner A
ChemMedChem; 2018 Sep; 13(18):1997-2007. PubMed ID: 29985556
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
