These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons. Chabwine JN; Talavera K; Van Den Bosch L; Callewaert G BMC Neurosci; 2015 Jul; 16():41. PubMed ID: 26169500 [TBL] [Abstract][Full Text] [Related]
3. Depolarizing chloride gradient in developing cochlear nucleus neurons: underlying mechanism and implication for calcium signaling. Witte M; Reinert T; Dietz B; Nerlich J; Rübsamen R; Milenkovic I Neuroscience; 2014 Mar; 261():207-22. PubMed ID: 24388924 [TBL] [Abstract][Full Text] [Related]
4. The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Kahle KT; Staley KJ Neurosurg Focus; 2008 Sep; 25(3):E22. PubMed ID: 18759624 [TBL] [Abstract][Full Text] [Related]
5. Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Hampel P; Römermann K; MacAulay N; Löscher W Sci Rep; 2018 Jun; 8(1):9877. PubMed ID: 29959396 [TBL] [Abstract][Full Text] [Related]
6. Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy. Brandt C; Seja P; Töllner K; Römermann K; Hampel P; Kalesse M; Kipper A; Feit PW; Lykke K; Toft-Bertelsen TL; Paavilainen P; Spoljaric I; Puskarjov M; MacAulay N; Kaila K; Löscher W Neuropharmacology; 2018 Dec; 143():186-204. PubMed ID: 30248303 [TBL] [Abstract][Full Text] [Related]
7. Increased Slc12a1 expression in β-cells and improved glucose disposal in Slc12a2 heterozygous mice. Alshahrani S; Almutairi MM; Kursan S; Dias-Junior E; Almiahuob MM; Aguilar-Bryan L; Di Fulvio M J Endocrinol; 2015 Dec; 227(3):153-65. PubMed ID: 26400961 [TBL] [Abstract][Full Text] [Related]
8. The search for NKCC1-selective drugs for the treatment of epilepsy: Structure-function relationship of bumetanide and various bumetanide derivatives in inhibiting the human cation-chloride cotransporter NKCC1A. Lykke K; Töllner K; Feit PW; Erker T; MacAulay N; Löscher W Epilepsy Behav; 2016 Jun; 59():42-9. PubMed ID: 27088517 [TBL] [Abstract][Full Text] [Related]
10. Functional characterization and osmoregulatory role of the Na Shaughnessy CA; McCormick SD Am J Physiol Regul Integr Comp Physiol; 2020 Jan; 318(1):R17-R29. PubMed ID: 31617750 [TBL] [Abstract][Full Text] [Related]
11. A patient with multisystem dysfunction carries a truncation mutation in human Delpire E; Wolfe L; Flores B; Koumangoye R; Schornak CC; Omer S; Pusey B; Lau C; Markello T; Adams DR Cold Spring Harb Mol Case Stud; 2016 Nov; 2(6):a001289. PubMed ID: 27900370 [TBL] [Abstract][Full Text] [Related]
12. NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders. Ben-Ari Y Trends Neurosci; 2017 Sep; 40(9):536-554. PubMed ID: 28818303 [TBL] [Abstract][Full Text] [Related]
13. Astrocytic NKCC1 inhibits seizures by buffering Cl Nguyen TD; Ishibashi M; Sinha AS; Watanabe M; Kato D; Horiuchi H; Wake H; Fukuda A Epilepsia; 2023 Dec; 64(12):3389-3403. PubMed ID: 37779224 [TBL] [Abstract][Full Text] [Related]
14. Inhibition of Na Zhang J; Pu H; Zhang H; Wei Z; Jiang X; Xu M; Zhang L; Zhang W; Liu J; Meng H; Stetler RA; Sun D; Chen J; Gao Y; Chen L Neurochem Int; 2017 Dec; 111():23-31. PubMed ID: 28577991 [TBL] [Abstract][Full Text] [Related]
15. Chloride cotransporter NKCC1 inhibitor bumetanide protects against white matter injury in a rodent model of periventricular leukomalacia. Jantzie LL; Hu MY; Park HK; Jackson MC; Yu J; Maxwell JR; Jensen FE Pediatr Res; 2015 Apr; 77(4):554-62. PubMed ID: 25585037 [TBL] [Abstract][Full Text] [Related]
16. NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility. Wang F; Wang X; Shapiro LA; Cotrina ML; Liu W; Wang EW; Gu S; Wang W; He X; Nedergaard M; Huang JH Brain Struct Funct; 2017 Apr; 222(3):1543-1556. PubMed ID: 27586142 [TBL] [Abstract][Full Text] [Related]
17. Genetic and pharmacological inactivation of apical Na Gregoriades JMC; Madaris A; Alvarez FJ; Alvarez-Leefmans FJ Am J Physiol Cell Physiol; 2019 Apr; 316(4):C525-C544. PubMed ID: 30576237 [TBL] [Abstract][Full Text] [Related]
18. Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia. Morita Y; Callicott JH; Testa LR; Mighdoll MI; Dickinson D; Chen Q; Tao R; Lipska BK; Kolachana B; Law AJ; Ye T; Straub RE; Weinberger DR; Kleinman JE; Hyde TM J Neurosci; 2014 Apr; 34(14):4929-40. PubMed ID: 24695712 [TBL] [Abstract][Full Text] [Related]
19. Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal. Zhu MH; Sung TS; Kurahashi M; O'Kane LE; O'Driscoll K; Koh SD; Sanders KM Am J Physiol Gastrointest Liver Physiol; 2016 Dec; 311(6):G1037-G1046. PubMed ID: 27742704 [TBL] [Abstract][Full Text] [Related]
20. Contributions of the Na⁺/K⁺-ATPase, NKCC1, and Kir4.1 to hippocampal K⁺ clearance and volume responses. Larsen BR; Assentoft M; Cotrina ML; Hua SZ; Nedergaard M; Kaila K; Voipio J; MacAulay N Glia; 2014 Apr; 62(4):608-22. PubMed ID: 24482245 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]