These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

201 related articles for article (PubMed ID: 26958828)

  • 1. Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site.
    Gerlits O; Wymore T; Das A; Shen CH; Parks JM; Smith JC; Weiss KL; Keen DA; Blakeley MP; Louis JM; Langan P; Weber IT; Kovalevsky A
    Angew Chem Int Ed Engl; 2016 Apr; 55(16):4924-7. PubMed ID: 26958828
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Direct determination of protonation states and visualization of hydrogen bonding in a glycoside hydrolase with neutron crystallography.
    Wan Q; Parks JM; Hanson BL; Fisher SZ; Ostermann A; Schrader TE; Graham DE; Coates L; Langan P; Kovalevsky A
    Proc Natl Acad Sci U S A; 2015 Oct; 112(40):12384-9. PubMed ID: 26392527
    [TBL] [Abstract][Full Text] [Related]  

  • 3. On the active site protonation state in aspartic proteases: implications for drug design.
    Sussman F; Villaverde MC; Domínguez JL; Danielson UH
    Curr Pharm Des; 2013; 19(23):4257-75. PubMed ID: 23170891
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography.
    Adachi M; Ohhara T; Kurihara K; Tamada T; Honjo E; Okazaki N; Arai S; Shoyama Y; Kimura K; Matsumura H; Sugiyama S; Adachi H; Takano K; Mori Y; Hidaka K; Kimura T; Hayashi Y; Kiso Y; Kuroki R
    Proc Natl Acad Sci U S A; 2009 Mar; 106(12):4641-6. PubMed ID: 19273847
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Proton transfer dynamics of GART: the pH-dependent catalytic mechanism examined by electrostatic calculations.
    Morikis D; Elcock AH; Jennings PA; McCammon JA
    Protein Sci; 2001 Nov; 10(11):2379-92. PubMed ID: 11604543
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Proton transfer and drug binding details revealed in neutron diffraction studies of wild-type and drug resistant HIV-1 protease.
    Kovalevsky A; Gerlits O; Beltran K; Weiss KL; Keen DA; Blakeley MP; Louis JM; Weber IT
    Methods Enzymol; 2020; 634():257-279. PubMed ID: 32093836
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer.
    Michalczyk R; Unkefer CJ; Bacik JP; Schrader TE; Ostermann A; Kovalevsky AY; McKenna R; Fisher SZ
    Proc Natl Acad Sci U S A; 2015 May; 112(18):5673-8. PubMed ID: 25902526
    [TBL] [Abstract][Full Text] [Related]  

  • 8. High-resolution neutron crystallography visualizes an OH-bound resting state of a copper-containing nitrite reductase.
    Fukuda Y; Hirano Y; Kusaka K; Inoue T; Tamada T
    Proc Natl Acad Sci U S A; 2020 Feb; 117(8):4071-4077. PubMed ID: 32041886
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Atomic resolution crystallography of a complex of triosephosphate isomerase with a reaction-intermediate analog: new insight in the proton transfer reaction mechanism.
    Alahuhta M; Wierenga RK
    Proteins; 2010 Jun; 78(8):1878-88. PubMed ID: 20235230
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hybrid quantum/classical molecular dynamics simulations of the proton transfer reactions catalyzed by ketosteroid isomerase: analysis of hydrogen bonding, conformational motions, and electrostatics.
    Chakravorty DK; Soudackov AV; Hammes-Schiffer S
    Biochemistry; 2009 Nov; 48(44):10608-19. PubMed ID: 19799395
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition and catalytic mechanism of HIV-1 aspartic protease.
    Silva AM; Cachau RE; Sham HL; Erickson JW
    J Mol Biol; 1996 Jan; 255(2):321-46. PubMed ID: 8551523
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Characterizing the protonation states of the catalytic residues in apo and substrate-bound human T-cell leukemia virus type 1 protease.
    Ma S; Vogt KA; Petrillo N; Ruhoff AJ
    Comput Biol Chem; 2015 Jun; 56():61-70. PubMed ID: 25889320
    [TBL] [Abstract][Full Text] [Related]  

  • 13. pH-REMD simulations indicate that the catalytic aspartates of HIV-1 protease exist primarily in a monoprotonated state.
    McGee TD; Edwards J; Roitberg AE
    J Phys Chem B; 2014 Nov; 118(44):12577-85. PubMed ID: 25340507
    [TBL] [Abstract][Full Text] [Related]  

  • 14. [Conformational changes in HIV-1 proteinase: effect of protonation of the active center on conformation of HIV-1 proteinase in water].
    Koval'skiĭ DB; Kanibolotskiĭ DS; Dubina VN; Korneliuk AI
    Ukr Biokhim Zh (1999); 2002; 74(6):135-8. PubMed ID: 12924029
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Perspectives on electrostatics and conformational motions in enzyme catalysis.
    Hanoian P; Liu CT; Hammes-Schiffer S; Benkovic S
    Acc Chem Res; 2015 Feb; 48(2):482-9. PubMed ID: 25565178
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dynamic and Electrostatic Effects on the Reaction Catalyzed by HIV-1 Protease.
    Krzemińska A; Moliner V; Świderek K
    J Am Chem Soc; 2016 Dec; 138(50):16283-16298. PubMed ID: 27935692
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Modeling the protonation states of the catalytic aspartates in beta-secretase.
    Rajamani R; Reynolds CH
    J Med Chem; 2004 Oct; 47(21):5159-66. PubMed ID: 15456259
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Active site dynamics and combined quantum mechanics/molecular mechanics (QM/MM) modelling of a HIV-1 reverse transcriptase/DNA/dTTP complex.
    Rungrotmongkol T; Mulholland AJ; Hannongbua S
    J Mol Graph Model; 2007 Jul; 26(1):1-13. PubMed ID: 17046299
    [TBL] [Abstract][Full Text] [Related]  

  • 19. X-ray, neutron and NMR studies of the catalytic mechanism of aspartic proteinases.
    Coates L; Erskine PT; Mall S; Gill R; Wood SP; Myles DA; Cooper JB
    Eur Biophys J; 2006 Sep; 35(7):559-66. PubMed ID: 16673078
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Towards investigation of the inhibitor-recognition mechanisms of drug-target proteins by neutron crystallography.
    Kuroki R; Okazaki N; Adachi M; Ohhara T; Kurihara K; Tamada T
    Acta Crystallogr D Biol Crystallogr; 2010 Nov; 66(Pt 11):1126-30. PubMed ID: 21041926
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.