These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

162 related articles for article (PubMed ID: 26967332)

  • 1. Dynamic Modelling Reveals 'Hotspots' on the Pathway to Enzyme-Substrate Complex Formation.
    Gordon SE; Weber DK; Downton MT; Wagner J; Perugini MA
    PLoS Comput Biol; 2016 Mar; 12(3):e1004811. PubMed ID: 26967332
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Characterization of a thermostable dihydrodipicolinate synthase from Thermoanaerobacter tengcongensis.
    Wolterink-van Loo S; Levisson M; Cabrières MC; Franssen MC; van der Oost J
    Extremophiles; 2008 May; 12(3):461-9. PubMed ID: 18340401
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase.
    Reboul CF; Porebski BT; Griffin MD; Dobson RC; Perugini MA; Gerrard JA; Buckle AM
    PLoS Comput Biol; 2012; 8(6):e1002537. PubMed ID: 22685390
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate.
    Devenish SR; Gerrard JA; Jameson GB; Dobson RC
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2008 Dec; 64(Pt 12):1092-5. PubMed ID: 19052357
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax.
    Voss JE; Scally SW; Taylor NL; Atkinson SC; Griffin MD; Hutton CA; Parker MW; Alderton MR; Gerrard JA; Dobson RC; Dogovski C; Perugini MA
    J Biol Chem; 2010 Feb; 285(8):5188-95. PubMed ID: 19948665
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition.
    Atkinson SC; Dogovski C; Downton MT; Czabotar PE; Dobson RC; Gerrard JA; Wagner J; Perugini MA
    Plant Mol Biol; 2013 Mar; 81(4-5):431-46. PubMed ID: 23354837
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate.
    Voss JE; Scally SW; Taylor NL; Dogovski C; Alderton MR; Hutton CA; Gerrard JA; Parker MW; Dobson RC; Perugini MA
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2009 Feb; 65(Pt 2):188-91. PubMed ID: 19194017
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterisation of dihydrodipicolinate synthase (DHDPS) from Bacillus anthracis.
    Domigan LJ; Scally SW; Fogg MJ; Hutton CA; Perugini MA; Dobson RC; Muscroft-Taylor AC; Gerrard JA; Devenish SR
    Biochim Biophys Acta; 2009 Oct; 1794(10):1510-6. PubMed ID: 19595801
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of the bona fide DHDPS from a common plant pathogen.
    Atkinson SC; Hor L; Dogovski C; Dobson RC; Perugini MA
    Proteins; 2014 Sep; 82(9):1869-83. PubMed ID: 24677246
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis.
    Dobson RC; Perugini MA; Jameson GB; Gerrard JA
    Biochimie; 2009 Aug; 91(8):1036-44. PubMed ID: 19505526
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate.
    Dobson RC; Griffin MD; Roberts SJ; Gerrard JA
    Biochimie; 2004; 86(4-5):311-5. PubMed ID: 15194235
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
    Kefala G; Evans GL; Griffin MD; Devenish SR; Pearce FG; Perugini MA; Gerrard JA; Weiss MS; Dobson RC
    Biochem J; 2008 Apr; 411(2):351-60. PubMed ID: 18062777
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen.
    Burgess BR; Dobson RCJ; Bailey MF; Atkinson SC; Griffin MDW; Jameson GB; Parker MW; Gerrard JA; Perugini MA
    J Biol Chem; 2008 Oct; 283(41):27598-27603. PubMed ID: 18684709
    [TBL] [Abstract][Full Text] [Related]  

  • 14. How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?
    Soares da Costa TP; Muscroft-Taylor AC; Dobson RC; Devenish SR; Jameson GB; Gerrard JA
    Biochimie; 2010 Jul; 92(7):837-45. PubMed ID: 20353808
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural and functional characterization of Staphylococcus aureus dihydrodipicolinate synthase.
    Girish TS; Sharma E; Gopal B
    FEBS Lett; 2008 Aug; 582(19):2923-30. PubMed ID: 18671976
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase.
    Dobson RC; Griffin MD; Devenish SR; Pearce FG; Hutton CA; Gerrard JA; Jameson GB; Perugini MA
    Protein Sci; 2008 Dec; 17(12):2080-90. PubMed ID: 18787203
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy.
    Blickling S; Renner C; Laber B; Pohlenz HD; Holak TA; Huber R
    Biochemistry; 1997 Jan; 36(1):24-33. PubMed ID: 8993314
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural Determinants Defining the Allosteric Inhibition of an Essential Antibiotic Target.
    Soares da Costa TP; Desbois S; Dogovski C; Gorman MA; Ketaren NE; Paxman JJ; Siddiqui T; Zammit LM; Abbott BM; Robins-Browne RM; Parker MW; Jameson GB; Hall NE; Panjikar S; Perugini MA
    Structure; 2016 Aug; 24(8):1282-1291. PubMed ID: 27427481
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Dihydrodipicolinate synthase from Campylobacter jejuni: kinetic mechanism of cooperative allosteric inhibition and inhibitor-induced substrate cooperativity.
    Skovpen YV; Palmer DR
    Biochemistry; 2013 Aug; 52(32):5454-62. PubMed ID: 23902434
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine.
    Muscroft-Taylor AC; Catchpole RJ; Dobson RC; Pearce FG; Perugini MA; Gerrard JA
    Arch Biochem Biophys; 2010 Nov; 503(2):202-6. PubMed ID: 20709017
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.