These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

169 related articles for article (PubMed ID: 26976746)

  • 1. Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.
    Eng CH; Yuzawa S; Wang G; Baidoo EE; Katz L; Keasling JD
    Biochemistry; 2016 Mar; 55(12):1677-80. PubMed ID: 26976746
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evaluating Ketoreductase Exchanges as a Means of Rationally Altering Polyketide Stereochemistry.
    Annaval T; Paris C; Leadlay PF; Jacob C; Weissman KJ
    Chembiochem; 2015 Jun; 16(9):1357-64. PubMed ID: 25851784
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase.
    Yuzawa S; Eng CH; Katz L; Keasling JD
    Biochemistry; 2013 Jun; 52(22):3791-3. PubMed ID: 23692164
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Substrate-dependent stereospecificity of Tyl-KR1: an isolated polyketide synthase ketoreductase domain from Streptomyces fradiae.
    Häckh M; Müller M; Lüdeke S
    Chemistry; 2013 Jul; 19(27):8922-8. PubMed ID: 23681606
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase.
    Castonguay R; Valenzano CR; Chen AY; Keatinge-Clay A; Khosla C; Cane DE
    J Am Chem Soc; 2008 Sep; 130(35):11598-9. PubMed ID: 18693734
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
    Liu C; Yuan M; Xu X; Wang L; Keatinge-Clay AT; Deng Z; Lin S; Zheng J
    J Struct Biol; 2018 Aug; 203(2):135-141. PubMed ID: 29626512
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.
    Siskos AP; Baerga-Ortiz A; Bali S; Stein V; Mamdani H; Spiteller D; Popovic B; Spencer JB; Staunton J; Weissman KJ; Leadlay PF
    Chem Biol; 2005 Oct; 12(10):1145-53. PubMed ID: 16242657
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.
    Wu J; Zaleski TJ; Valenzano C; Khosla C; Cane DE
    J Am Chem Soc; 2005 Dec; 127(49):17393-404. PubMed ID: 16332089
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure and stereospecificity of the dehydratase domain from the terminal module of the rifamycin polyketide synthase.
    Gay D; You YO; Keatinge-Clay A; Cane DE
    Biochemistry; 2013 Dec; 52(49):8916-28. PubMed ID: 24274103
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Autonomous folding of interdomain regions of a modular polyketide synthase.
    Richter CD; Stanmore DA; Miguel RN; Moncrieffe MC; Tran L; Brewerton S; Meersman F; Broadhurst RW; Weissman KJ
    FEBS J; 2007 May; 274(9):2196-209. PubMed ID: 17419733
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.
    Koryakina I; McArthur JB; Draelos MM; Williams GJ
    Org Biomol Chem; 2013 Jul; 11(27):4449-58. PubMed ID: 23681002
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase.
    Guo X; Liu T; Deng Z; Cane DE
    Biochemistry; 2012 Jan; 51(4):879-87. PubMed ID: 22229794
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.
    Baerga-Ortiz A; Popovic B; Siskos AP; O'Hare HM; Spiteller D; Williams MG; Campillo N; Spencer JB; Leadlay PF
    Chem Biol; 2006 Mar; 13(3):277-85. PubMed ID: 16638533
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Insights into the stereospecificity of ketoreduction in a modular polyketide synthase.
    Kwan DH; Tosin M; Schläger N; Schulz F; Leadlay PF
    Org Biomol Chem; 2011 Apr; 9(7):2053-6. PubMed ID: 21340070
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases.
    You YO; Khosla C; Cane DE
    J Am Chem Soc; 2013 May; 135(20):7406-9. PubMed ID: 23659177
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A fungal ketoreductase domain that displays substrate-dependent stereospecificity.
    Zhou H; Gao Z; Qiao K; Wang J; Vederas JC; Tang Y
    Nat Chem Biol; 2012 Mar; 8(4):331-3. PubMed ID: 22406519
    [TBL] [Abstract][Full Text] [Related]  

  • 17. High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.
    O'Hare HM; Baerga-Ortiz A; Popovic B; Spencer JB; Leadlay PF
    Chem Biol; 2006 Mar; 13(3):287-96. PubMed ID: 16638534
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A polylinker approach to reductive loop swaps in modular polyketide synthases.
    Kellenberger L; Galloway IS; Sauter G; Böhm G; Hanefeld U; Cortés J; Staunton J; Leadlay PF
    Chembiochem; 2008 Nov; 9(16):2740-9. PubMed ID: 18937219
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling α-substituent stereochemistry.
    Zheng J; Piasecki SK; Keatinge-Clay AT
    ACS Chem Biol; 2013 Sep; 8(9):1964-71. PubMed ID: 23755878
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange.
    Garg A; Xie X; Keatinge-Clay A; Khosla C; Cane DE
    J Am Chem Soc; 2014 Jul; 136(29):10190-3. PubMed ID: 25004372
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.