These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 26996235)

  • 1. Histone Deacetylase 8: Characterization of Physiological Divalent Metal Catalysis.
    Nechay MR; Gallup NM; Morgenstern A; Smith QA; Eberhart ME; Alexandrova AN
    J Phys Chem B; 2016 Jul; 120(26):5884-95. PubMed ID: 26996235
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function .
    Dowling DP; Gattis SG; Fierke CA; Christianson DW
    Biochemistry; 2010 Jun; 49(24):5048-56. PubMed ID: 20545365
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetics and thermodynamics of metal-binding to histone deacetylase 8.
    Kim B; Pithadia AS; Fierke CA
    Protein Sci; 2015 Mar; 24(3):354-65. PubMed ID: 25516458
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism.
    Castaneda CA; Lopez JE; Joseph CG; Scholle MD; Mrksich M; Fierke CA
    Biochemistry; 2017 Oct; 56(42):5663-5670. PubMed ID: 28937750
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Catalytic activity and inhibition of human histone deacetylase 8 is dependent on the identity of the active site metal ion.
    Gantt SL; Gattis SG; Fierke CA
    Biochemistry; 2006 May; 45(19):6170-8. PubMed ID: 16681389
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Restoring histone deacetylase activity by waste product release. A view from molecular mechanics simulations with mammalian HDAC8.
    Pietra F
    Chem Biodivers; 2015 Apr; 12(4):503-12. PubMed ID: 25879496
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzyme.
    Singh RK; Suzuki T; Mandal T; Balsubramanian N; Haldar M; Mueller DJ; Strode JA; Cook G; Mallik S; Srivastava DK
    Biochemistry; 2014 Dec; 53(48):7445-58. PubMed ID: 25407689
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences.
    Shaik MM; Bhattacharjee N; Feliks M; Ng KK; Field MJ
    Proteins; 2017 Aug; 85(8):1435-1445. PubMed ID: 28383118
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Can human prolidase enzyme use different metals for full catalytic activity?
    Alberto ME; Leopoldini M; Russo N
    Inorg Chem; 2011 Apr; 50(8):3394-403. PubMed ID: 21425789
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
    Vannini A; Volpari C; Filocamo G; Casavola EC; Brunetti M; Renzoni D; Chakravarty P; Paolini C; De Francesco R; Gallinari P; Steinkühler C; Di Marco S
    Proc Natl Acad Sci U S A; 2004 Oct; 101(42):15064-9. PubMed ID: 15477595
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A proton-shuttle reaction mechanism for histone deacetylase 8 and the catalytic role of metal ions.
    Wu R; Wang S; Zhou N; Cao Z; Zhang Y
    J Am Chem Soc; 2010 Jul; 132(27):9471-9. PubMed ID: 20568751
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Thiol versus hydroxamate as zinc binding group in HDAC inhibition: An ab initio QM/MM molecular dynamics study.
    Gong W; Wu R; Zhang Y
    J Comput Chem; 2015 Nov; 36(30):2228-35. PubMed ID: 26452222
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.
    Marek M; Shaik TB; Heimburg T; Chakrabarti A; Lancelot J; Ramos-Morales E; Da Veiga C; Kalinin D; Melesina J; Robaa D; Schmidtkunz K; Suzuki T; Holl R; Ennifar E; Pierce RJ; Jung M; Sippl W; Romier C
    J Med Chem; 2018 Nov; 61(22):10000-10016. PubMed ID: 30347148
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
    Dowling DP; Gantt SL; Gattis SG; Fierke CA; Christianson DW
    Biochemistry; 2008 Dec; 47(51):13554-63. PubMed ID: 19053282
    [TBL] [Abstract][Full Text] [Related]  

  • 15. General Base-General Acid Catalysis in Human Histone Deacetylase 8.
    Gantt SM; Decroos C; Lee MS; Gullett LE; Bowman CM; Christianson DW; Fierke CA
    Biochemistry; 2016 Feb; 55(5):820-32. PubMed ID: 26806311
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural and Functional Influence of the Glycine-Rich Loop G
    Porter NJ; Christianson NH; Decroos C; Christianson DW
    Biochemistry; 2016 Dec; 55(48):6718-6729. PubMed ID: 27933794
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases.
    Somoza JR; Skene RJ; Katz BA; Mol C; Ho JD; Jennings AJ; Luong C; Arvai A; Buggy JJ; Chi E; Tang J; Sang BC; Verner E; Wynands R; Leahy EM; Dougan DR; Snell G; Navre M; Knuth MW; Swanson RV; McRee DE; Tari LW
    Structure; 2004 Jul; 12(7):1325-34. PubMed ID: 15242608
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant.
    Welker Leng KR; Castañeda CA; Decroos C; Islam B; Haider SM; Christianson DW; Fierke CA
    Biochemistry; 2019 Nov; 58(45):4480-4493. PubMed ID: 31633931
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel structural insights into class I and II histone deacetylases.
    Ficner R
    Curr Top Med Chem; 2009; 9(3):235-40. PubMed ID: 19355988
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of metal ions in catalysis by enolase: an ordered kinetic mechanism for a single substrate enzyme.
    Poyner RR; Cleland WW; Reed GH
    Biochemistry; 2001 Jul; 40(27):8009-17. PubMed ID: 11434770
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.