These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 27007499)

  • 1. Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators.
    Wang W; Hong JS; Rab A; Sorscher EJ; Kirk KL
    PLoS One; 2016; 11(3):e0152232. PubMed ID: 27007499
    [TBL] [Abstract][Full Text] [Related]  

  • 2. On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator.
    Yu YC; Sohma Y; Hwang TC
    J Physiol; 2016 Jun; 594(12):3227-44. PubMed ID: 26846474
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product.
    Haggie PM; Phuan PW; Tan JA; Xu H; Avramescu RG; Perdomo D; Zlock L; Nielson DW; Finkbeiner WE; Lukacs GL; Verkman AS
    J Biol Chem; 2017 Jan; 292(3):771-785. PubMed ID: 27895116
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither ATP binding nor dimerization of the nucleotide-binding domains.
    Wang W; Bernard K; Li G; Kirk KL
    J Biol Chem; 2007 Feb; 282(7):4533-4544. PubMed ID: 17178710
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Physiological and pharmacological characterization of the N1303K mutant CFTR.
    DeStefano S; Gees M; Hwang TC
    J Cyst Fibros; 2018 Sep; 17(5):573-581. PubMed ID: 29887518
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Deletion of phenylalanine 508 causes attenuated phosphorylation-dependent activation of CFTR chloride channels.
    Wang F; Zeltwanger S; Hu S; Hwang TC
    J Physiol; 2000 May; 524 Pt 3(Pt 3):637-48. PubMed ID: 10790148
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation.
    Mutyam V; Libby EF; Peng N; Hadjiliadis D; Bonk M; Solomon GM; Rowe SM
    J Cyst Fibros; 2017 Jan; 16(1):24-29. PubMed ID: 27707539
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural mechanisms for defective CFTR gating caused by the Q1412X mutation, a severe Class VI pathogenic mutation in cystic fibrosis.
    Yeh JT; Yu YC; Hwang TC
    J Physiol; 2019 Jan; 597(2):543-560. PubMed ID: 30408177
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Differential thermostability and response to cystic fibrosis transmembrane conductance regulator potentiators of human and mouse F508del-CFTR.
    Bose SJ; Bijvelds MJC; Wang Y; Liu J; Cai Z; Bot AGM; de Jonge HR; Sheppard DN
    Am J Physiol Lung Cell Mol Physiol; 2019 Jul; 317(1):L71-L86. PubMed ID: 30969810
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Functional rescue of c.3846G>A (W1282X) in patient-derived nasal cultures achieved by inhibition of nonsense mediated decay and protein modulators with complementary mechanisms of action.
    Laselva O; Eckford PD; Bartlett C; Ouyang H; Gunawardena TN; Gonska T; Moraes TJ; Bear CE
    J Cyst Fibros; 2020 Sep; 19(5):717-727. PubMed ID: 31831337
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Restoration of R117H CFTR folding and function in human airway cells through combination treatment with VX-809 and VX-770.
    Gentzsch M; Ren HY; Houck SA; Quinney NL; Cholon DM; Sopha P; Chaudhry IG; Das J; Dokholyan NV; Randell SH; Cyr DM
    Am J Physiol Lung Cell Mol Physiol; 2016 Sep; 311(3):L550-9. PubMed ID: 27402691
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nonsense-mediated RNA Decay Pathway Inhibition Restores Expression and Function of W1282X CFTR.
    Keenan MM; Huang L; Jordan NJ; Wong E; Cheng Y; Valley HC; Mahiou J; Liang F; Bihler H; Mense M; Guo S; Monia BP
    Am J Respir Cell Mol Biol; 2019 Sep; 61(3):290-300. PubMed ID: 30836009
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators.
    Phuan PW; Son JH; Tan JA; Li C; Musante I; Zlock L; Nielson DW; Finkbeiner WE; Kurth MJ; Galietta LJ; Haggie PM; Verkman AS
    J Cyst Fibros; 2018 Sep; 17(5):595-606. PubMed ID: 29903467
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Potentiation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- currents by the chemical solvent tetrahydrofuran.
    Hughes LK; Ju M; Sheppard DN
    Mol Membr Biol; 2008 Sep; 25(6-7):528-38. PubMed ID: 18989824
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Potentiation of the cystic fibrosis transmembrane conductance regulator by VX-770 involves stabilization of the pre-hydrolytic, O
    Langron E; Prins S; Vergani P
    Br J Pharmacol; 2018 Oct; 175(20):3990-4002. PubMed ID: 30107029
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A common mechanism for CFTR potentiators.
    Yeh HI; Sohma Y; Conrath K; Hwang TC
    J Gen Physiol; 2017 Dec; 149(12):1105-1118. PubMed ID: 29079713
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents.
    Ai T; Bompadre SG; Wang X; Hu S; Li M; Hwang TC
    Mol Pharmacol; 2004 Jun; 65(6):1415-26. PubMed ID: 15155835
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl- channel activity.
    Berger AL; Randak CO; Ostedgaard LS; Karp PH; Vermeer DW; Welsh MJ
    J Biol Chem; 2005 Feb; 280(7):5221-6. PubMed ID: 15582996
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A single amino acid substitution in CFTR converts ATP to an inhibitory ligand.
    Lin WY; Jih KY; Hwang TC
    J Gen Physiol; 2014 Oct; 144(4):311-20. PubMed ID: 25225552
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains.
    Csanády L; Chan KW; Seto-Young D; Kopsco DC; Nairn AC; Gadsby DC
    J Gen Physiol; 2000 Sep; 116(3):477-500. PubMed ID: 10962022
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.