BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

477 related articles for article (PubMed ID: 27019408)

  • 41. α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism.
    Yun SP; Kim D; Kim S; Kim S; Karuppagounder SS; Kwon SH; Lee S; Kam TI; Lee S; Ham S; Park JH; Dawson VL; Dawson TM; Lee Y; Ko HS
    Mol Neurodegener; 2018 Jan; 13(1):1. PubMed ID: 29310663
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model.
    Yang SY; Taanman JW; Gegg M; Schapira AHV
    Hum Mol Genet; 2022 Jul; 31(14):2396-2405. PubMed ID: 35179198
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice.
    Glajch KE; Moors TE; Chen Y; Bechade PA; Nam AY; Rajsombath MM; McCaffery TD; Dettmer U; Weihofen A; Hirst WD; Selkoe DJ; Nuber S
    Proc Natl Acad Sci U S A; 2021 Aug; 118(31):. PubMed ID: 34326260
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.
    Wegrzynowicz M; Bar-On D; Calo' L; Anichtchik O; Iovino M; Xia J; Ryazanov S; Leonov A; Giese A; Dalley JW; Griesinger C; Ashery U; Spillantini MG
    Acta Neuropathol; 2019 Oct; 138(4):575-595. PubMed ID: 31165254
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Mechanisms of Glucocerebrosidase Dysfunction in Parkinson's Disease.
    Chatterjee D; Krainc D
    J Mol Biol; 2023 Jun; 435(12):168023. PubMed ID: 36828270
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases.
    Yap TL; Gruschus JM; Velayati A; Westbroek W; Goldin E; Moaven N; Sidransky E; Lee JC
    J Biol Chem; 2011 Aug; 286(32):28080-8. PubMed ID: 21653695
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Parkinson's disease-associated
    Mori A; Hatano T; Inoshita T; Shiba-Fukushima K; Koinuma T; Meng H; Kubo SI; Spratt S; Cui C; Yamashita C; Miki Y; Yamamoto K; Hirabayashi T; Murakami M; Takahashi Y; Shindou H; Nonaka T; Hasegawa M; Okuzumi A; Imai Y; Hattori N
    Proc Natl Acad Sci U S A; 2019 Oct; 116(41):20689-20699. PubMed ID: 31548400
    [TBL] [Abstract][Full Text] [Related]  

  • 48. A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.
    Aflaki E; Borger DK; Moaven N; Stubblefield BK; Rogers SA; Patnaik S; Schoenen FJ; Westbroek W; Zheng W; Sullivan P; Fujiwara H; Sidhu R; Khaliq ZM; Lopez GJ; Goldstein DS; Ory DS; Marugan J; Sidransky E
    J Neurosci; 2016 Jul; 36(28):7441-52. PubMed ID: 27413154
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Glucocerebrosidase as a therapeutic target for Parkinson's disease.
    Chen Y; Sam R; Sharma P; Chen L; Do J; Sidransky E
    Expert Opin Ther Targets; 2020 Apr; 24(4):287-294. PubMed ID: 32106725
    [No Abstract]   [Full Text] [Related]  

  • 50. Lysosomal impairment in Parkinson's disease.
    Dehay B; Martinez-Vicente M; Caldwell GA; Caldwell KA; Yue Z; Cookson MR; Klein C; Vila M; Bezard E
    Mov Disord; 2013 Jun; 28(6):725-32. PubMed ID: 23580333
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Glucosylsphingosine Promotes α-Synuclein Pathology in Mutant GBA-Associated Parkinson's Disease.
    Taguchi YV; Liu J; Ruan J; Pacheco J; Zhang X; Abbasi J; Keutzer J; Mistry PK; Chandra SS
    J Neurosci; 2017 Oct; 37(40):9617-9631. PubMed ID: 28847804
    [TBL] [Abstract][Full Text] [Related]  

  • 52. The deglycase activity of DJ-1 mitigates α-synuclein glycation and aggregation in dopaminergic cells: Role of oxidative stress mediated downregulation of DJ-1 in Parkinson's disease.
    Sharma N; Rao SP; Kalivendi SV
    Free Radic Biol Med; 2019 May; 135():28-37. PubMed ID: 30796974
    [TBL] [Abstract][Full Text] [Related]  

  • 53. [Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies].
    Orimo S
    Rinsho Shinkeigaku; 2008 Jan; 48(1):11-24. PubMed ID: 18386627
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation.
    Fishbein I; Kuo YM; Giasson BI; Nussbaum RL
    Brain; 2014 Dec; 137(Pt 12):3235-47. PubMed ID: 25351739
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein.
    Bae EJ; Yang NY; Song M; Lee CS; Lee JS; Jung BC; Lee HJ; Kim S; Masliah E; Sardi SP; Lee SJ
    Nat Commun; 2014 Aug; 5():4755. PubMed ID: 25156829
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Glucocerebrosidase and its relevance to Parkinson disease.
    Do J; McKinney C; Sharma P; Sidransky E
    Mol Neurodegener; 2019 Aug; 14(1):36. PubMed ID: 31464647
    [TBL] [Abstract][Full Text] [Related]  

  • 57. A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.
    Cosden M; Jinn S; Yao L; Gretzula CA; Kandebo M; Toolan D; Hatcher NG; Ma L; Lemaire W; Adam GC; Burlein C; Minnick C; Flick R; Watt ML; Mulhearn J; Fraley M; Drolet RE; Marcus JN; Smith SM
    Neurobiol Dis; 2021 Nov; 159():105507. PubMed ID: 34509608
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export.
    Martin S; Smolders S; Van den Haute C; Heeman B; van Veen S; Crosiers D; Beletchi I; Verstraeten A; Gossye H; Gelders G; Pals P; Hamouda NN; Engelborghs S; Martin JJ; Eggermont J; De Deyn PP; Cras P; Baekelandt V; Vangheluwe P; Van Broeckhoven C;
    Acta Neuropathol; 2020 Jun; 139(6):1001-1024. PubMed ID: 32172343
    [TBL] [Abstract][Full Text] [Related]  

  • 59. Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease.
    Watson L; Keatinge M; Gegg M; Bai Q; Sandulescu MC; Vardi A; Futerman AH; Schapira AHV; Burton EA; Bandmann O
    Neurobiol Dis; 2019 Jul; 127():563-569. PubMed ID: 30981829
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Glucocerebrosidase haploinsufficiency in A53T α-synuclein mice impacts disease onset and course.
    Tayebi N; Parisiadou L; Berhe B; Gonzalez AN; Serra-Vinardell J; Tamargo RJ; Maniwang E; Sorrentino Z; Fujiwara H; Grey RJ; Hassan S; Blech-Hermoni YN; Chen C; McGlinchey R; Makariou-Pikis C; Brooks M; Ginns EI; Ory DS; Giasson BI; Sidransky E
    Mol Genet Metab; 2017 Dec; 122(4):198-208. PubMed ID: 29173981
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 24.