138 related articles for article (PubMed ID: 2703405)
41. Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro.
Siim BG; van Zijl PL; Brown JM
Br J Cancer; 1996 Apr; 73(8):952-60. PubMed ID: 8611431
[TBL] [Abstract][Full Text] [Related]
42. Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin.
Dorie MJ; Brown JM
Cancer Res; 1993 Oct; 53(19):4633-6. PubMed ID: 8402639
[TBL] [Abstract][Full Text] [Related]
43. Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity.
Baker MA; Zeman EM; Hirst VK; Brown JM
Cancer Res; 1988 Nov; 48(21):5947-52. PubMed ID: 3167847
[TBL] [Abstract][Full Text] [Related]
44. Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma.
Sun JR; Brown JM
Cancer Res; 1989 Oct; 49(20):5664-70. PubMed ID: 2790784
[TBL] [Abstract][Full Text] [Related]
45. Interaction of SR-4233 with hyperthermia and radiation in the FSaIIC murine fibrosarcoma tumor system in vitro and in vivo.
Herman TS; Teicher BA; Coleman CN
Cancer Res; 1990 Aug; 50(16):5055-9. PubMed ID: 2379171
[TBL] [Abstract][Full Text] [Related]
46. Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors.
Brown JM; Lemmon MJ
Cancer Res; 1990 Dec; 50(24):7745-9. PubMed ID: 2253217
[TBL] [Abstract][Full Text] [Related]
47. Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Kotandeniya D; Ganley B; Gates KS
Bioorg Med Chem Lett; 2002 Sep; 12(17):2325-9. PubMed ID: 12161126
[TBL] [Abstract][Full Text] [Related]
48. Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation.
Brown JM; Lemmon MJ
Int J Radiat Oncol Biol Phys; 1991 Mar; 20(3):457-61. PubMed ID: 1995531
[TBL] [Abstract][Full Text] [Related]
49. Photodegradation of the benzotriazine 1,4-Di-N-oxide hypoxia-activated prodrug SN30000 in aqueous solution.
Gu Y; Jaiswal JK; Wang J; Hicks KO; Hay MP; Wilson WR
J Pharm Sci; 2014 Nov; 103(11):3464-3472. PubMed ID: 25212501
[TBL] [Abstract][Full Text] [Related]
50. Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
Shinde SS; Anderson RF; Hay MP; Gamage SA; Denny WA
J Am Chem Soc; 2004 Jun; 126(25):7865-74. PubMed ID: 15212534
[TBL] [Abstract][Full Text] [Related]
51. DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine.
Dorie MJ; Kovacs MS; Gabalski EC; Adam M; Le QT; Bloch DA; Pinto HA; Terris DJ; Brown JM
Neoplasia; 1999 Nov; 1(5):461-7. PubMed ID: 10933062
[TBL] [Abstract][Full Text] [Related]
52. SR-4233 (Tirapazamine) acts as an uncoupler of oxidative phosphorylation in human MCF-7 breast carcinoma cells.
Ara G; Coleman CN; Teicher BA
Cancer Lett; 1994 Oct; 85(2):195-203. PubMed ID: 7954337
[TBL] [Abstract][Full Text] [Related]
53. Mitochondrial dysfunction after aerobic exposure to the hypoxic cytotoxin tirapazamine.
Wouters BG; Delahoussaye YM; Evans JW; Birrell GW; Dorie MJ; Wang J; MacDermed D; Chiu RK; Brown JM
Cancer Res; 2001 Jan; 61(1):145-52. PubMed ID: 11196153
[TBL] [Abstract][Full Text] [Related]
54. Synthesis, structure and hypoxic cytotoxicity of 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Jiang F; Weng Q; Sheng R; Xia Q; He Q; Yang B; Hu Y
Arch Pharm (Weinheim); 2007 May; 340(5):258-63. PubMed ID: 17464965
[TBL] [Abstract][Full Text] [Related]
55. Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.
Gu Y; Chang TT; Wang J; Jaiswal JK; Edwards D; Downes NJ; Liyanage HDS; Lynch CRH; Pruijn FB; Hickey AJR; Hay MP; Wilson WR; Hicks KO
Front Pharmacol; 2017; 8():531. PubMed ID: 28848445
[TBL] [Abstract][Full Text] [Related]
56. Aerobic radiosensitization by SR 4233 in rodent and human cells: mechanistic and therapeutic implications.
Zeman EM; Brown JM
Int J Radiat Biol; 1991 Jan; 59(1):117-31. PubMed ID: 1671059
[TBL] [Abstract][Full Text] [Related]
57. 1,2,4-Benzotriazine 1,4-dioxides. An important class of hypoxic cytotoxins with antitumor activity.
Kelson AB; McNamara JP; Pandey A; Ryan KJ; Dorie MJ; McAfee PA; Menke DR; Brown JM; Tracy M
Anticancer Drug Des; 1998 Sep; 13(6):575-92. PubMed ID: 9755719
[TBL] [Abstract][Full Text] [Related]
58. Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine.
Olive PL
Br J Cancer; 1995 Mar; 71(3):529-36. PubMed ID: 7880735
[TBL] [Abstract][Full Text] [Related]
59. Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.
Shen X; Rajapakse A; Gallazzi F; Junnotula V; Fuchs-Knotts T; Glaser R; Gates KS
Chem Res Toxicol; 2014 Jan; 27(1):111-8. PubMed ID: 24328261
[TBL] [Abstract][Full Text] [Related]
60. DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Birincioglu M; Jaruga P; Chowdhury G; Rodriguez H; Dizdaroglu M; Gates KS
J Am Chem Soc; 2003 Sep; 125(38):11607-15. PubMed ID: 13129365
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
