BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 27038496)

  • 21. Pharmacological and Toxicological Properties of the Potent Oral
    Wagner SL; Rynearson KD; Duddy SK; Zhang C; Nguyen PD; Becker A; Vo U; Masliah D; Monte L; Klee JB; Echmalian CM; Xia W; Quinti L; Johnson G; Lin JH; Kim DY; Mobley WC; Rissman RA; Tanzi RE
    J Pharmacol Exp Ther; 2017 Jul; 362(1):31-44. PubMed ID: 28416568
    [TBL] [Abstract][Full Text] [Related]  

  • 22. The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.
    Best JD; Smith DW; Reilly MA; O'Donnell R; Lewis HD; Ellis S; Wilkie N; Rosahl TW; Laroque PA; Boussiquet-Leroux C; Churcher I; Atack JR; Harrison T; Shearman MS
    J Pharmacol Exp Ther; 2007 Feb; 320(2):552-8. PubMed ID: 17099072
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
    Toyn JH; Boy KM; Raybon J; Meredith JE; Robertson AS; Guss V; Hoque N; Sweeney F; Zhuo X; Clarke W; Snow K; Denton RR; Zuev D; Thompson LA; Morrison J; Grace J; Berisha F; Furlong M; Wang JS; Lentz KA; Padmanabha R; Cook L; Wei C; Drexler DM; Macor JE; Albright CF; Gasior M; Olson RE; Hong Q; Soares HD; AbuTarif M; Ahlijanian MK
    J Pharmacol Exp Ther; 2016 Jul; 358(1):125-37. PubMed ID: 27189974
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides.
    Zhang L; Song L; Terracina G; Liu Y; Pramanik B; Parker E
    Biochemistry; 2001 Apr; 40(16):5049-55. PubMed ID: 11305921
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.
    Shi XP; Tugusheva K; Bruce JE; Lucka A; Wu GX; Chen-Dodson E; Price E; Li Y; Xu M; Huang Q; Sardana MK; Hazuda DJ
    J Biol Chem; 2003 Jun; 278(23):21286-94. PubMed ID: 12665519
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Interacting with γ-secretase for treating Alzheimer's disease: from inhibition to modulation.
    Panza F; Frisardi V; Solfrizzi V; Imbimbo BP; Logroscino G; Santamato A; Greco A; Seripa D; Pilotto A
    Curr Med Chem; 2011; 18(35):5430-47. PubMed ID: 22087836
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor.
    Barten DM; Guss VL; Corsa JA; Loo A; Hansel SB; Zheng M; Munoz B; Srinivasan K; Wang B; Robertson BJ; Polson CT; Wang J; Roberts SB; Hendrick JP; Anderson JJ; Loy JK; Denton R; Verdoorn TA; Smith DW; Felsenstein KM
    J Pharmacol Exp Ther; 2005 Feb; 312(2):635-43. PubMed ID: 15452193
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Phenotypic analysis of images of zebrafish treated with Alzheimer's gamma-secretase inhibitors.
    Arslanova D; Yang T; Xu X; Wong ST; Augelli-Szafran CE; Xia W
    BMC Biotechnol; 2010 Mar; 10():24. PubMed ID: 20307292
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Design and optimization of tricyclic gamma-secretase modulators.
    Shi J; Zuev D; Xu L; Lentz KA; Grace JE; Toyn JH; Olson RE; Macor JE; Thompson LA
    Bioorg Med Chem Lett; 2016 Mar; 26(5):1498-502. PubMed ID: 26848108
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Piperazinyl pyrimidine derivatives as potent gamma-secretase modulators.
    Rivkin A; Ahearn SP; Chichetti SM; Kim YR; Li C; Rosenau A; Kattar SD; Jung J; Shah S; Hughes BL; Crispino JL; Middleton RE; Szewczak AA; Munoz B; Shearman MS
    Bioorg Med Chem Lett; 2010 Feb; 20(3):1269-71. PubMed ID: 20022243
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
    Neitzel ML; Aubele DL; Marugg JL; Jagodzinski JJ; Konradi AW; Pleiss MA; Szoke B; Zmolek W; Goldbach E; Quinn KP; Sauer JM; Brigham EF; Wallace W; Bova MP; Hemphill S; Basi G
    Bioorg Med Chem Lett; 2011 Jun; 21(12):3715-20. PubMed ID: 21571529
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
    Bergstrom CP; Sloan CP; Wang HH; Parker MF; Smith DW; Zheng M; Hansel SB; Polson CT; Barber LE; Bursuker I; Guss VL; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
    Bioorg Med Chem Lett; 2008 Jan; 18(1):175-8. PubMed ID: 18023581
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity.
    Barten DM; Meredith JE; Zaczek R; Houston JG; Albright CF
    Drugs R D; 2006; 7(2):87-97. PubMed ID: 16542055
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.
    D'Onofrio G; Panza F; Frisardi V; Solfrizzi V; Imbimbo BP; Paroni G; Cascavilla L; Seripa D; Pilotto A
    Expert Opin Drug Discov; 2012 Jan; 7(1):19-37. PubMed ID: 22468891
    [TBL] [Abstract][Full Text] [Related]  

  • 36. γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes.
    Imbimbo BP; Giardina GA
    Curr Top Med Chem; 2011; 11(12):1555-70. PubMed ID: 21510832
    [TBL] [Abstract][Full Text] [Related]  

  • 37. 2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors.
    Parker MF; Barten DM; Bergstrom CP; Bronson JJ; Corsa JA; Dee MF; Gai Y; Guss VL; Higgins MA; Keavy DJ; Loo A; Mate RA; Marcin LR; McElhone KE; Polson CT; Roberts SB; Macor JE
    Bioorg Med Chem Lett; 2012 Nov; 22(22):6828-31. PubMed ID: 23046960
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Alzheimer's disease and Notch signaling.
    Woo HN; Park JS; Gwon AR; Arumugam TV; Jo DG
    Biochem Biophys Res Commun; 2009 Dec; 390(4):1093-7. PubMed ID: 19853579
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase.
    Durkin JT; Murthy S; Husten EJ; Trusko SP; Savage MJ; Rotella DP; Greenberg BD; Siman R
    J Biol Chem; 1999 Jul; 274(29):20499-504. PubMed ID: 10400678
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.
    Rynearson KD; Buckle RN; Barnes KD; Herr RJ; Mayhew NJ; Paquette WD; Sakwa SA; Nguyen PD; Johnson G; Tanzi RE; Wagner SL
    Bioorg Med Chem Lett; 2016 Aug; 26(16):3928-37. PubMed ID: 27426299
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.