These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

822 related articles for article (PubMed ID: 27049945)

  • 1. Reductive carboxylation supports redox homeostasis during anchorage-independent growth.
    Jiang L; Shestov AA; Swain P; Yang C; Parker SJ; Wang QA; Terada LS; Adams ND; McCabe MT; Pietrak B; Schmidt S; Metallo CM; Dranka BP; Schwartz B; DeBerardinis RJ
    Nature; 2016 Apr; 532(7598):255-8. PubMed ID: 27049945
    [TBL] [Abstract][Full Text] [Related]  

  • 2. FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress.
    Dai W; Wang Z; Wang G; Wang QA; DeBerardinis R; Jiang L
    Cell Rep; 2023 Aug; 42(8):112971. PubMed ID: 37578864
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.
    Wise DR; Ward PS; Shay JE; Cross JR; Gruber JJ; Sachdeva UM; Platt JM; DeMatteo RG; Simon MC; Thompson CB
    Proc Natl Acad Sci U S A; 2011 Dec; 108(49):19611-6. PubMed ID: 22106302
    [TBL] [Abstract][Full Text] [Related]  

  • 4. IDH1-Driven Reductive Carboxylation Supports Anchorage Independence.
    Cancer Discov; 2016 Jun; 6(6):570. PubMed ID: 27125548
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells.
    Zhang R; Chen D; Fan H; Wu R; Tu J; Zhang FQ; Wang M; Zheng H; Qu CK; Elf SE; Faubert B; He YY; Bissonnette MB; Gao X; DeBerardinis RJ; Chen J
    Cell Chem Biol; 2022 Jul; 29(7):1200-1208.e6. PubMed ID: 35429459
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Reductive carboxylation supports growth in tumour cells with defective mitochondria.
    Mullen AR; Wheaton WW; Jin ES; Chen PH; Sullivan LB; Cheng T; Yang Y; Linehan WM; Chandel NS; DeBerardinis RJ
    Nature; 2011 Nov; 481(7381):385-8. PubMed ID: 22101431
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion.
    MacDonald MJ; Brown LJ; Longacre MJ; Stoker SW; Kendrick MA; Hasan NM
    Biochim Biophys Acta; 2013 Nov; 1830(11):5104-11. PubMed ID: 23876293
    [TBL] [Abstract][Full Text] [Related]  

  • 8. FASN-deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress.
    Dai W; Wang Z; Wang G; Wang QA; DeBerardinis R; Jiang L
    bioRxiv; 2023 Mar; ():. PubMed ID: 36993662
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells.
    Smolková K; Dvořák A; Zelenka J; Vítek L; Ježek P
    Int J Biochem Cell Biol; 2015 Aug; 65():125-33. PubMed ID: 26007236
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
    Metallo CM; Gameiro PA; Bell EL; Mattaini KR; Yang J; Hiller K; Jewell CM; Johnson ZR; Irvine DJ; Guarente L; Kelleher JK; Vander Heiden MG; Iliopoulos O; Stephanopoulos G
    Nature; 2011 Nov; 481(7381):380-4. PubMed ID: 22101433
    [TBL] [Abstract][Full Text] [Related]  

  • 11. IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism.
    Grassian AR; Parker SJ; Davidson SM; Divakaruni AS; Green CR; Zhang X; Slocum KL; Pu M; Lin F; Vickers C; Joud-Caldwell C; Chung F; Yin H; Handly ED; Straub C; Growney JD; Vander Heiden MG; Murphy AN; Pagliarini R; Metallo CM
    Cancer Res; 2014 Jun; 74(12):3317-31. PubMed ID: 24755473
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.
    Leonardi R; Subramanian C; Jackowski S; Rock CO
    J Biol Chem; 2012 Apr; 287(18):14615-20. PubMed ID: 22442146
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein.
    Jiang L; Boufersaoui A; Yang C; Ko B; Rakheja D; Guevara G; Hu Z; DeBerardinis RJ
    Metab Eng; 2017 Sep; 43(Pt B):198-207. PubMed ID: 27856334
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism.
    Ye S; Xu P; Huang M; Chen X; Zeng S; Wang Q; Chen J; Li K; Gao W; Liu R; Liu J; Shao Y; Zhang H; Xu Y; Zhang Q; Zhong Z; Wei Z; Wang J; Hao B; Huang W; Liu Q
    Cell Death Dis; 2020 May; 11(5):312. PubMed ID: 32366855
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.
    Mullen AR; Hu Z; Shi X; Jiang L; Boroughs LK; Kovacs Z; Boriack R; Rakheja D; Sullivan LB; Linehan WM; Chandel NS; DeBerardinis RJ
    Cell Rep; 2014 Jun; 7(5):1679-1690. PubMed ID: 24857658
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
    Reitman ZJ; Duncan CG; Poteet E; Winters A; Yan LJ; Gooden DM; Spasojevic I; Boros LG; Yang SH; Yan H
    J Biol Chem; 2014 Aug; 289(34):23318-28. PubMed ID: 24986863
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Functional requirement of a wild-type allele for mutant IDH1 to suppress anchorage-independent growth through redox homeostasis.
    Tiburcio PDB; Xiao B; Berg S; Asper S; Lyne S; Zhang Y; Zhu X; Yan H; Huang LE
    Acta Neuropathol; 2018 Feb; 135(2):285-298. PubMed ID: 29288440
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells.
    Lee WD; Mukha D; Aizenshtein E; Shlomi T
    Nat Commun; 2019 Mar; 10(1):1351. PubMed ID: 30903027
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.
    Hollinshead KER; Munford H; Eales KL; Bardella C; Li C; Escribano-Gonzalez C; Thakker A; Nonnenmacher Y; Kluckova K; Jeeves M; Murren R; Cuozzo F; Ye D; Laurenti G; Zhu W; Hiller K; Hodson DJ; Hua W; Tomlinson IP; Ludwig C; Mao Y; Tennant DA
    Cell Rep; 2018 Mar; 22(12):3107-3114. PubMed ID: 29562167
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle.
    Gameiro PA; Laviolette LA; Kelleher JK; Iliopoulos O; Stephanopoulos G
    J Biol Chem; 2013 May; 288(18):12967-77. PubMed ID: 23504317
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 42.