111 related articles for article (PubMed ID: 27074625)
1. Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer.
Christiansen E; Hudson BD; Hansen AH; Milligan G; Ulven T
J Med Chem; 2016 May; 59(10):4849-58. PubMed ID: 27074625
[TBL] [Abstract][Full Text] [Related]
2. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43).
Hansen AH; Sergeev E; Pandey SK; Hudson BD; Christiansen E; Milligan G; Ulven T
J Med Chem; 2017 Jul; 60(13):5638-5645. PubMed ID: 28570808
[TBL] [Abstract][Full Text] [Related]
3. Free fatty acid receptor 1 (FFA1/GPR40) agonists: mesylpropoxy appendage lowers lipophilicity and improves ADME properties.
Christiansen E; Due-Hansen ME; Urban C; Grundmann M; Schröder R; Hudson BD; Milligan G; Cawthorne MA; Kostenis E; Kassack MU; Ulven T
J Med Chem; 2012 Jul; 55(14):6624-8. PubMed ID: 22724451
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.
Li Z; Qiu Q; Xu X; Wang X; Jiao L; Su X; Pan M; Huang W; Qian H
Eur J Med Chem; 2016 May; 113():246-57. PubMed ID: 26945112
[TBL] [Abstract][Full Text] [Related]
5. Ligands at Free Fatty Acid Receptor 1 (GPR40).
Hara T
Handb Exp Pharmacol; 2017; 236():1-16. PubMed ID: 27757762
[TBL] [Abstract][Full Text] [Related]
6. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.
Christiansen E; Urban C; Grundmann M; Due-Hansen ME; Hagesaether E; Schmidt J; Pardo L; Ullrich S; Kostenis E; Kassack M; Ulven T
J Med Chem; 2011 Oct; 54(19):6691-703. PubMed ID: 21854074
[TBL] [Abstract][Full Text] [Related]
7. Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold.
Krasavin M; Lukin A; Zhurilo N; Kovalenko A; Zahanich I; Zozulya S; Moore D; Tikhonova IG
Bioorg Med Chem; 2016 Jul; 24(13):2954-2963. PubMed ID: 27229618
[TBL] [Abstract][Full Text] [Related]
8. Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists.
Krasavin M; Lukin A; Bakholdina A; Zhurilo N; Onopchenko O; Borysko P; Zozulya S; Moore D; Tikhonova IG
Eur J Med Chem; 2017 Nov; 140():229-238. PubMed ID: 28938138
[TBL] [Abstract][Full Text] [Related]
9. Structure-based optimization of free fatty acid receptor 1 agonists bearing thiazole scaffold.
Li Z; Xu X; Hou J; Wang S; Jiang H; Zhang L
Bioorg Chem; 2018 Apr; 77():429-435. PubMed ID: 29433092
[TBL] [Abstract][Full Text] [Related]
10. Progress in the discovery and development of small-molecule modulators of G-protein-coupled receptor 40 (GPR40/FFA1/FFAR1): an emerging target for type 2 diabetes.
Bharate SB; Nemmani KV; Vishwakarma RA
Expert Opin Ther Pat; 2009 Feb; 19(2):237-64. PubMed ID: 19441920
[TBL] [Abstract][Full Text] [Related]
11. Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency.
Krasavin M; Lukin A; Bagnyukova D; Zhurilo N; Zahanich I; Zozulya S
J Enzyme Inhib Med Chem; 2017 Dec; 32(1):29-36. PubMed ID: 27781494
[TBL] [Abstract][Full Text] [Related]
12. Discovery of novel pyrrole-based scaffold as potent and orally bioavailable free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.
Li Z; Pan M; Su X; Dai Y; Fu M; Cai X; Shi W; Huang W; Qian H
Bioorg Med Chem; 2016 May; 24(9):1981-7. PubMed ID: 27020683
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine.
Kong D; Guo S; Yang Y; Guo B; Xie X; Hu W
Bioorg Med Chem Lett; 2019 Mar; 29(6):848-852. PubMed ID: 30685095
[TBL] [Abstract][Full Text] [Related]
14. Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.
Krasavin M; Lukin A; Bagnyukova D; Zhurilo N; Zahanich I; Zozulya S; Ihalainen J; Forsberg MM; Lehtonen M; Rautio J; Moore D; Tikhonova IG
Bioorg Med Chem; 2016 Nov; 24(21):5481-5494. PubMed ID: 27647366
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, and structure-activity relationships of 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazoles as TGR5 agonists.
Zhu J; Ye Y; Ning M; Mándi A; Feng Y; Zou Q; Kurtán T; Leng Y; Shen J
ChemMedChem; 2013 Jul; 8(7):1210-23. PubMed ID: 23757200
[TBL] [Abstract][Full Text] [Related]
16. Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40).
Zahanich I; Kondratov I; Naumchyk V; Kheylik Y; Platonov M; Zozulya S; Krasavin M
Bioorg Med Chem Lett; 2015 Aug; 25(16):3105-11. PubMed ID: 26096679
[TBL] [Abstract][Full Text] [Related]
17. Discovery of novel free fatty acid receptor 1 agonists bearing triazole core via click chemistry.
Li Z; Yang J; Wang X; Li H; Liu C; Wang N; Huang W; Qian H
Bioorg Med Chem; 2016 Nov; 24(21):5449-5454. PubMed ID: 27624524
[TBL] [Abstract][Full Text] [Related]
18. Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold.
Li Z; Ren Q; Wang X; Zhou Z; Hu L; Deng L; Guan L; Qiu Q
Bioorg Chem; 2019 Nov; 92():103209. PubMed ID: 31487621
[TBL] [Abstract][Full Text] [Related]
19. Agonists and protein kinase C-activation induce phosphorylation and internalization of FFA1 receptors.
Sosa-Alvarado C; Hernández-Méndez A; Romero-Ávila MT; Sánchez-Reyes OB; Takei Y; Tsujimoto G; Hirasawa A; García-Sáinz JA
Eur J Pharmacol; 2015 Dec; 768():108-15. PubMed ID: 26526350
[TBL] [Abstract][Full Text] [Related]
20. Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835.
Krasavin M; Lukin A; Bagnyukova D; Zhurilo N; Golovanov A; Zozulya S; Zahanich I; Moore D; Tikhonova IG
Eur J Med Chem; 2017 Feb; 127():357-368. PubMed ID: 28076825
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]