297 related articles for article (PubMed ID: 27074832)
1. One-Step Conjugation Method for Site-Specific Antibody-Drug Conjugates through Reactive Cysteine-Engineered Antibodies.
Shinmi D; Taguchi E; Iwano J; Yamaguchi T; Masuda K; Enokizono J; Shiraishi Y
Bioconjug Chem; 2016 May; 27(5):1324-31. PubMed ID: 27074832
[TBL] [Abstract][Full Text] [Related]
2. Identification of highly reactive cysteine residues at less exposed positions in the Fab constant region for site-specific conjugation.
Shiraishi Y; Muramoto T; Nagatomo K; Shinmi D; Honma E; Masuda K; Yamasaki M
Bioconjug Chem; 2015 Jun; 26(6):1032-40. PubMed ID: 25978737
[TBL] [Abstract][Full Text] [Related]
3. High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers.
Ohri R; Bhakta S; Fourie-O'Donohue A; Dela Cruz-Chuh J; Tsai SP; Cook R; Wei B; Ng C; Wong AW; Bos AB; Farahi F; Bhakta J; Pillow TH; Raab H; Vandlen R; Polakis P; Liu Y; Erickson H; Junutula JR; Kozak KR
Bioconjug Chem; 2018 Feb; 29(2):473-485. PubMed ID: 29425028
[TBL] [Abstract][Full Text] [Related]
4. Engineering THIOMABs for site-specific conjugation of thiol-reactive linkers.
Bhakta S; Raab H; Junutula JR
Methods Mol Biol; 2013; 1045():189-203. PubMed ID: 23913148
[TBL] [Abstract][Full Text] [Related]
5. Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.
Shen BQ; Xu K; Liu L; Raab H; Bhakta S; Kenrick M; Parsons-Reponte KL; Tien J; Yu SF; Mai E; Li D; Tibbitts J; Baudys J; Saad OM; Scales SJ; McDonald PJ; Hass PE; Eigenbrot C; Nguyen T; Solis WA; Fuji RN; Flagella KM; Patel D; Spencer SD; Khawli LA; Ebens A; Wong WL; Vandlen R; Kaur S; Sliwkowski MX; Scheller RH; Polakis P; Junutula JR
Nat Biotechnol; 2012 Jan; 30(2):184-9. PubMed ID: 22267010
[TBL] [Abstract][Full Text] [Related]
6. Attachment Site Cysteine Thiol pK
Vollmar BS; Wei B; Ohri R; Zhou J; He J; Yu SF; Leipold D; Cosino E; Yee S; Fourie-O'Donohue A; Li G; Phillips GL; Kozak KR; Kamath A; Xu K; Lee G; Lazar GA; Erickson HK
Bioconjug Chem; 2017 Oct; 28(10):2538-2548. PubMed ID: 28885827
[TBL] [Abstract][Full Text] [Related]
7. Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides.
Christie RJ; Fleming R; Bezabeh B; Woods R; Mao S; Harper J; Joseph A; Wang Q; Xu ZQ; Wu H; Gao C; Dimasi N
J Control Release; 2015 Dec; 220(Pt B):660-70. PubMed ID: 26387744
[TBL] [Abstract][Full Text] [Related]
8. Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates.
Tumey LN; Li F; Rago B; Han X; Loganzo F; Musto S; Graziani EI; Puthenveetil S; Casavant J; Marquette K; Clark T; Bikker J; Bennett EM; Barletta F; Piche-Nicholas N; Tam A; O'Donnell CJ; Gerber HP; Tchistiakova L
AAPS J; 2017 Jul; 19(4):1123-1135. PubMed ID: 28439809
[TBL] [Abstract][Full Text] [Related]
9. Site-Specific Conjugation of Thiol-Reactive Cytotoxic Agents to Nonnative Cysteines of Engineered Monoclonal Antibodies.
Dickgiesser S; Kellner R; Kolmar H; Rasche N
Methods Mol Biol; 2019; 2033():1-14. PubMed ID: 31332743
[TBL] [Abstract][Full Text] [Related]
10. The Properties of Cysteine-Conjugated Antibody-Drug Conjugates Are Impacted by the IgG Subclass.
Datta-Mannan A; Choi H; Stokell D; Tang J; Murphy A; Wrobleski A; Feng Y
AAPS J; 2018 Sep; 20(6):103. PubMed ID: 30255287
[TBL] [Abstract][Full Text] [Related]
11. Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability.
Sussman D; Westendorf L; Meyer DW; Leiske CI; Anderson M; Okeley NM; Alley SC; Lyon R; Sanderson RJ; Carter PJ; Benjamin DR
Protein Eng Des Sel; 2018 Feb; 31(2):47-54. PubMed ID: 29370435
[TBL] [Abstract][Full Text] [Related]
12. Characterization of Ring-Opening Reaction of Succinimide Linkers in ADCs.
Zheng K; Chen Y; Wang J; Zheng L; Hutchinson M; Persson J; Ji J
J Pharm Sci; 2019 Jan; 108(1):133-141. PubMed ID: 30458165
[TBL] [Abstract][Full Text] [Related]
13. A Two-Step Immunocapture LC/MS/MS Assay for Plasma Stability and Payload Migration Assessment of Cysteine-Maleimide-Based Antibody Drug Conjugates.
Dong L; Li C; Locuson C; Chen S; Qian MG
Anal Chem; 2018 May; 90(10):5989-5994. PubMed ID: 29688004
[TBL] [Abstract][Full Text] [Related]
14. Light Chain Q166C Mutation Permits One-step Site Specific Conjugation on Monoclonal Antibodies.
Li M; Song C; Li J; Min J; Cao L; Wang L; Ma N
Chembiochem; 2023 Jul; 24(13):e202200780. PubMed ID: 37079449
[TBL] [Abstract][Full Text] [Related]
15. A Genetically Encoded Photocaged Cysteine for Facile Site-Specific Introduction of Conjugation-Ready Thiol Residues in Antibodies.
Osgood AO; Roy SJS; Koo D; Gu R; Chatterjee A
Bioconjug Chem; 2024 Apr; 35(4):457-464. PubMed ID: 38548654
[TBL] [Abstract][Full Text] [Related]
16. Design and Validation of Linkers for Site-Specific Preparation of Antibody-Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site.
Kumar A; Mao S; Dimasi N; Gao C
Int J Mol Sci; 2020 Sep; 21(18):. PubMed ID: 32961794
[TBL] [Abstract][Full Text] [Related]
17. Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation.
Christie RJ; Tiberghien AC; Du Q; Bezabeh B; Fleming R; Shannon A; Mao S; Breen S; Zhang J; Zhong H; Harper J; Wu H; Howard PW; Gao C
Antibodies (Basel); 2017 Nov; 6(4):. PubMed ID: 31548535
[TBL] [Abstract][Full Text] [Related]
18. Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates.
Sadowsky JD; Pillow TH; Chen J; Fan F; He C; Wang Y; Yan G; Yao H; Xu Z; Martin S; Zhang D; Chu P; Dela Cruz-Chuh J; O'Donohue A; Li G; Del Rosario G; He J; Liu L; Ng C; Su D; Lewis Phillips GD; Kozak KR; Yu SF; Xu K; Leipold D; Wai J
Bioconjug Chem; 2017 Aug; 28(8):2086-2098. PubMed ID: 28636382
[TBL] [Abstract][Full Text] [Related]
19. Characterization of cysteine-linked conjugation profiles of immunoglobulin G1 and immunoglobulin G2 antibody-drug conjugates.
Wiggins B; Liu-Shin L; Yamaguchi H; Ratnaswamy G
J Pharm Sci; 2015 Apr; 104(4):1362-72. PubMed ID: 25631158
[TBL] [Abstract][Full Text] [Related]
20. Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
Ponte JF; Sun X; Yoder NC; Fishkin N; Laleau R; Coccia J; Lanieri L; Bogalhas M; Wang L; Wilhelm S; Widdison W; Pinkas J; Keating TA; Chari R; Erickson HK; Lambert JM
Bioconjug Chem; 2016 Jul; 27(7):1588-98. PubMed ID: 27174129
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]