BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

135 related articles for article (PubMed ID: 27078579)

  • 1. Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors.
    Liu Q; Chen X; Chen W; Yuan X; Su H; Shen J; Xu Y
    J Med Chem; 2016 May; 59(10):5115-20. PubMed ID: 27078579
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Regioselectivity of thiouracil alkylation: Application to optimization of Darapladib synthesis.
    Guibbal F; Bénard S; Patché J; Meneyrol V; Couprie J; Yong-Sang J; Meilhac O; Jestin E
    Bioorg Med Chem Lett; 2018 Feb; 28(4):787-792. PubMed ID: 29336874
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of Potent and Orally Active Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors as a Potential Therapy for Diabetic Macular Edema.
    Chen X; Wang K; Xu W; Ma Q; Chen M; Du L; Mo M; Wang Y; Shen J
    J Med Chem; 2016 Mar; 59(6):2674-87. PubMed ID: 26927682
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis.
    Zhang J; Xu DL; Liu XB; Bi SJ; Zhao T; Sui SJ; Ji XP; Lu QH
    Yonsei Med J; 2016 Mar; 57(2):321-7. PubMed ID: 26847282
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.
    Woolford AJ; Pero JE; Aravapalli S; Berdini V; Coyle JE; Day PJ; Dodson AM; Grondin P; Holding FP; Lee LY; Li P; Manas ES; Marino J; Martin AC; McCleland BW; McMenamin RL; Murray CW; Neipp CE; Page LW; Patel VK; Potvain F; Rich S; Rivero RA; Smith K; Somers DO; Trottet L; Velagaleti R; Williams G; Xie R
    J Med Chem; 2016 Jun; 59(11):5356-67. PubMed ID: 27167608
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of imidazole and triazole derivatives as Lp-PLA₂ inhibitors and the unexpected discovery of highly potent quaternary ammonium salts.
    Wang K; Xu W; Liu Y; Zhang W; Wang W; Shen J; Wang Y
    Bioorg Med Chem Lett; 2013 Mar; 23(5):1187-92. PubMed ID: 23385210
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Impact of tyrosine nitration at positions Tyr307 and Tyr335 on structural dynamics of Lipoprotein-associated phospholipase A
    Gurung AB; Bhattacharjee A
    Int J Biol Macromol; 2018 Feb; 107(Pt B):1956-1964. PubMed ID: 29051098
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Lipoprotein-associated phospholipase A2: The story continues.
    Huang F; Wang K; Shen J
    Med Res Rev; 2020 Jan; 40(1):79-134. PubMed ID: 31140638
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2.
    Liu Q; Huang F; Yuan X; Wang K; Zou Y; Shen J; Xu Y
    J Med Chem; 2017 Dec; 60(24):10231-10244. PubMed ID: 29193967
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma.
    Tellis CC; Tselepis AD
    Biochim Biophys Acta; 2009 May; 1791(5):327-38. PubMed ID: 19272461
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach.
    Huang F; Hu H; Wang K; Peng C; Xu W; Zhang Y; Gao J; Liu Y; Zhou H; Huang R; Li M; Shen J; Xu Y
    J Med Chem; 2020 Jul; 63(13):7052-7065. PubMed ID: 32459096
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A
    Mouchlis VD; Morisseau C; Hammock BD; Li S; McCammon JA; Dennis EA
    Bioorg Med Chem; 2016 Oct; 24(20):4801-4811. PubMed ID: 27320659
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine Derivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors.
    Chen X; Xu W; Wang K; Mo M; Zhang W; Du L; Yuan X; Xu Y; Wang Y; Shen J
    J Med Chem; 2015 Nov; 58(21):8529-41. PubMed ID: 26479945
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Atherosclerotic plaque inflammation varies between vascular sites and correlates with response to inhibition of lipoprotein-associated phospholipase A2.
    Fenning RS; Burgert ME; Hamamdzic D; Peyster EG; Mohler ER; Kangovi S; Jucker BM; Lenhard SC; Macphee CH; Wilensky RL
    J Am Heart Assoc; 2015 Feb; 4(2):. PubMed ID: 25672369
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Impact of a non-synonymous Q281R polymorphism on structure of human Lipoprotein-Associated Phospholipase A
    Gurung AB; Bhattacharjee A
    J Cell Biochem; 2018 Aug; 119(8):7009-7021. PubMed ID: 29737567
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Lipoprotein-associated phospholipase A2.
    McConnell JP; Hoefner DM
    Clin Lab Med; 2006 Sep; 26(3):679-97, vii. PubMed ID: 16938590
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Met117 oxidation leads to enhanced flexibility of cardiovascular biomarker- lipoprotein- associated phospholipase A
    Gurung AB; Bhattacharjee A
    Int J Biol Macromol; 2018 Jun; 112():831-840. PubMed ID: 29427679
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Lipoprotein-associated phospholipase A(2) and atherosclerosis.
    Wilensky RL; Macphee CH
    Curr Opin Lipidol; 2009 Oct; 20(5):415-20. PubMed ID: 19667981
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Lipoprotein-associated phospholipase A2 in coronary heart disease: Review and meta-analysis.
    Li D; Zhao L; Yu J; Zhang W; Du R; Liu X; Liu Y; Chen Y; Zeng R; Cao Y; Zeng Z; Zhao Z; Wu J
    Clin Chim Acta; 2017 Feb; 465():22-29. PubMed ID: 27956130
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Lipoprotein-associated phospholipase A2 as a biomarker of coronary heart disease and a therapeutic target.
    Packard CJ
    Curr Opin Cardiol; 2009 Jul; 24(4):358-63. PubMed ID: 19417639
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.