267 related articles for article (PubMed ID: 27129778)
1. Contribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the Liver.
Hwang S; Hartman IZ; Calhoun LN; Garland K; Young GA; Mitsche MA; McDonald J; Xu F; Engelking L; DeBose-Boyd RA
J Biol Chem; 2016 Jun; 291(26):13479-94. PubMed ID: 27129778
[TBL] [Abstract][Full Text] [Related]
2. Post-Translational Regulation of HMG CoA Reductase.
Jo Y; DeBose-Boyd RA
Cold Spring Harb Perspect Biol; 2022 Dec; 14(12):. PubMed ID: 35940903
[TBL] [Abstract][Full Text] [Related]
3. Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver.
Hwang S; Nguyen AD; Jo Y; Engelking LJ; Brugarolas J; DeBose-Boyd RA
J Biol Chem; 2017 Jun; 292(22):9382-9393. PubMed ID: 28416613
[TBL] [Abstract][Full Text] [Related]
4. Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase.
Faulkner RA; Yang Y; Tsien J; Qin T; DeBose-Boyd RA
Proc Natl Acad Sci U S A; 2024 Feb; 121(7):e2318822121. PubMed ID: 38319967
[TBL] [Abstract][Full Text] [Related]
5. Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.
Jiang LY; Jiang W; Tian N; Xiong YN; Liu J; Wei J; Wu KY; Luo J; Shi XJ; Song BL
J Biol Chem; 2018 Mar; 293(11):4047-4055. PubMed ID: 29374057
[TBL] [Abstract][Full Text] [Related]
6. Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
Loregger A; Raaben M; Tan J; Scheij S; Moeton M; van den Berg M; Gelberg-Etel H; Stickel E; Roitelman J; Brummelkamp T; Zelcer N
Arterioscler Thromb Vasc Biol; 2017 Nov; 37(11):2064-2074. PubMed ID: 28882874
[TBL] [Abstract][Full Text] [Related]
7. UbiA prenyltransferase domain-containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids.
Schumacher MM; Jun DJ; Johnson BM; DeBose-Boyd RA
J Biol Chem; 2018 Jan; 293(1):312-323. PubMed ID: 29167270
[TBL] [Abstract][Full Text] [Related]
8. Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.
Chen H; Qi X; Faulkner RA; Schumacher MM; Donnelly LM; DeBose-Boyd RA; Li X
Nat Commun; 2022 Jul; 13(1):4273. PubMed ID: 35879350
[TBL] [Abstract][Full Text] [Related]
9. The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.
Menzies SA; Volkmar N; van den Boomen DJ; Timms RT; Dickson AS; Nathan JA; Lehner PJ
Elife; 2018 Dec; 7():. PubMed ID: 30543180
[TBL] [Abstract][Full Text] [Related]
10. Underlying mechanisms for sterol-induced ubiquitination and ER-associated degradation of HMG CoA reductase.
Johnson BM; DeBose-Boyd RA
Semin Cell Dev Biol; 2018 Sep; 81():121-128. PubMed ID: 29107682
[TBL] [Abstract][Full Text] [Related]
11. Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Morris LL; Hartman IZ; Jun DJ; Seemann J; DeBose-Boyd RA
J Biol Chem; 2014 Jul; 289(27):19053-66. PubMed ID: 24860107
[TBL] [Abstract][Full Text] [Related]
12. Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.
Ohashi K; Osuga J; Tozawa R; Kitamine T; Yagyu H; Sekiya M; Tomita S; Okazaki H; Tamura Y; Yahagi N; Iizuka Y; Harada K; Gotoda T; Shimano H; Yamada N; Ishibashi S
J Biol Chem; 2003 Oct; 278(44):42936-41. PubMed ID: 12920113
[TBL] [Abstract][Full Text] [Related]
13. Posttranslational Regulation of HMG CoA Reductase, the Rate-Limiting Enzyme in Synthesis of Cholesterol.
Schumacher MM; DeBose-Boyd RA
Annu Rev Biochem; 2021 Jun; 90():659-679. PubMed ID: 34153214
[TBL] [Abstract][Full Text] [Related]
14. Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis.
Tan JME; Cook ECL; van den Berg M; Scheij S; Zelcer N; Loregger A
Atherosclerosis; 2019 Feb; 281():137-142. PubMed ID: 30658189
[TBL] [Abstract][Full Text] [Related]
15. Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase.
DeBose-Boyd RA
Cell Res; 2008 Jun; 18(6):609-21. PubMed ID: 18504457
[TBL] [Abstract][Full Text] [Related]
16. Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.
Nguyen AD; Lee SH; DeBose-Boyd RA
J Biol Chem; 2009 Sep; 284(39):26778-88. PubMed ID: 19638338
[TBL] [Abstract][Full Text] [Related]
17. Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing.
Chen L; Ma MY; Sun M; Jiang LY; Zhao XT; Fang XX; Man Lam S; Shui GH; Luo J; Shi XJ; Song BL
J Lipid Res; 2019 Oct; 60(10):1765-1775. PubMed ID: 31455613
[TBL] [Abstract][Full Text] [Related]
18. Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase.
Jo Y; Debose-Boyd RA
Crit Rev Biochem Mol Biol; 2010 Jun; 45(3):185-98. PubMed ID: 20482385
[TBL] [Abstract][Full Text] [Related]
19. Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells.
Elsabrouty R; Jo Y; Dinh TT; DeBose-Boyd RA
Mol Biol Cell; 2013 Nov; 24(21):3300-8. PubMed ID: 24025715
[TBL] [Abstract][Full Text] [Related]
20. Inhibition of human 3-hydroxy-3-methylglutaryl CoA reductase by peptides leading to cholesterol homeostasis through SREBP2 pathway in HepG2 cells.
Kumar V; Sharma P; Bairagya HR; Sharma S; Singh TP; Tiku PK
Biochim Biophys Acta Proteins Proteom; 2019 Jun; 1867(6):604-615. PubMed ID: 30954578
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]