248 related articles for article (PubMed ID: 27155453)
1. The extreme N-terminus of TDP-43 mediates the cytoplasmic aggregation of TDP-43 and associated toxicity in vivo.
Sasaguri H; Chew J; Xu YF; Gendron TF; Garrett A; Lee CW; Jansen-West K; Bauer PO; Perkerson EA; Tong J; Stetler C; Zhang YJ
Brain Res; 2016 Sep; 1647():57-64. PubMed ID: 27155453
[TBL] [Abstract][Full Text] [Related]
2. Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
Tsai KJ; Yang CH; Fang YH; Cho KH; Chien WL; Wang WT; Wu TW; Lin CP; Fu WM; Shen CK
J Exp Med; 2010 Aug; 207(8):1661-73. PubMed ID: 20660618
[TBL] [Abstract][Full Text] [Related]
3. [The molecular mechanisms of intracellular TDP-43 aggregates].
Nonaka T; Arai T; Hasegawa M
Brain Nerve; 2009 Nov; 61(11):1292-300. PubMed ID: 19938686
[TBL] [Abstract][Full Text] [Related]
4. Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death.
Xiao S; Sanelli T; Chiang H; Sun Y; Chakrabartty A; Keith J; Rogaeva E; Zinman L; Robertson J
Acta Neuropathol; 2015 Jul; 130(1):49-61. PubMed ID: 25788357
[TBL] [Abstract][Full Text] [Related]
5. Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes.
Takeuchi R; Tada M; Shiga A; Toyoshima Y; Konno T; Sato T; Nozaki H; Kato T; Horie M; Shimizu H; Takebayashi H; Onodera O; Nishizawa M; Kakita A; Takahashi H
Acta Neuropathol Commun; 2016 Jun; 4(1):61. PubMed ID: 27338935
[TBL] [Abstract][Full Text] [Related]
6. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity.
Zhang YJ; Xu YF; Cook C; Gendron TF; Roettges P; Link CD; Lin WL; Tong J; Castanedes-Casey M; Ash P; Gass J; Rangachari V; Buratti E; Baralle F; Golde TE; Dickson DW; Petrucelli L
Proc Natl Acad Sci U S A; 2009 May; 106(18):7607-12. PubMed ID: 19383787
[TBL] [Abstract][Full Text] [Related]
7. Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis.
Tan RH; Yang Y; Kim WS; Dobson-Stone C; Kwok JB; Kiernan MC; Halliday GM
Acta Neuropathol Commun; 2017 Oct; 5(1):76. PubMed ID: 29078806
[TBL] [Abstract][Full Text] [Related]
8. [Clinical and pathological spectrum of TDP-43 associated ALS].
Onodera O; Yokoseki A; Tan CF; Ishihara T; Nishiira Y; Toyoshima Y; Kakita A; Nishizawa M; Takahashi H
Rinsho Shinkeigaku; 2010 Nov; 50(11):940-2. PubMed ID: 21921519
[TBL] [Abstract][Full Text] [Related]
9. The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.
Zhang YJ; Caulfield T; Xu YF; Gendron TF; Hubbard J; Stetler C; Sasaguri H; Whitelaw EC; Cai S; Lee WC; Petrucelli L
Hum Mol Genet; 2013 Aug; 22(15):3112-22. PubMed ID: 23575225
[TBL] [Abstract][Full Text] [Related]
10. [TDP-43 proteinopathies: ALS and frontotemporal dementias].
Prudlo J
Fortschr Neurol Psychiatr; 2009 Aug; 77 Suppl 1():S25-7. PubMed ID: 19685386
[TBL] [Abstract][Full Text] [Related]
11. Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains.
Seyfried NT; Gozal YM; Dammer EB; Xia Q; Duong DM; Cheng D; Lah JJ; Levey AI; Peng J
Mol Cell Proteomics; 2010 Apr; 9(4):705-18. PubMed ID: 20047951
[TBL] [Abstract][Full Text] [Related]
12. Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.
Nonaka T; Kametani F; Arai T; Akiyama H; Hasegawa M
Hum Mol Genet; 2009 Sep; 18(18):3353-64. PubMed ID: 19515851
[TBL] [Abstract][Full Text] [Related]
13. Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions.
Nishihira Y; Tan CF; Onodera O; Toyoshima Y; Yamada M; Morita T; Nishizawa M; Kakita A; Takahashi H
Acta Neuropathol; 2008 Aug; 116(2):169-82. PubMed ID: 18481073
[TBL] [Abstract][Full Text] [Related]
14. Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS.
Ke YD; van Hummel A; Stevens CH; Gladbach A; Ippati S; Bi M; Lee WS; Krüger S; van der Hoven J; Volkerling A; Bongers A; Halliday G; Haass NK; Kiernan M; Delerue F; Ittner LM
Acta Neuropathol; 2015 Nov; 130(5):661-78. PubMed ID: 26437864
[TBL] [Abstract][Full Text] [Related]
15. Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.
Khosravi B; Hartmann H; May S; Möhl C; Ederle H; Michaelsen M; Schludi MH; Dormann D; Edbauer D
Hum Mol Genet; 2017 Feb; 26(4):790-800. PubMed ID: 28040728
[TBL] [Abstract][Full Text] [Related]
16. Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo.
Porta S; Xu Y; Restrepo CR; Kwong LK; Zhang B; Brown HJ; Lee EB; Trojanowski JQ; Lee VM
Nat Commun; 2018 Oct; 9(1):4220. PubMed ID: 30310141
[TBL] [Abstract][Full Text] [Related]
17. Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies.
Miguel L; Frébourg T; Campion D; Lecourtois M
Neurobiol Dis; 2011 Feb; 41(2):398-406. PubMed ID: 20951205
[TBL] [Abstract][Full Text] [Related]
18. TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA.
Qin H; Lim LZ; Wei Y; Song J
Proc Natl Acad Sci U S A; 2014 Dec; 111(52):18619-24. PubMed ID: 25503365
[TBL] [Abstract][Full Text] [Related]
19. Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
van Eersel J; Ke YD; Gladbach A; Bi M; Götz J; Kril JJ; Ittner LM
PLoS One; 2011; 6(7):e22850. PubMed ID: 21829535
[TBL] [Abstract][Full Text] [Related]
20. TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Arai T; Hasegawa M; Akiyama H; Ikeda K; Nonaka T; Mori H; Mann D; Tsuchiya K; Yoshida M; Hashizume Y; Oda T
Biochem Biophys Res Commun; 2006 Dec; 351(3):602-11. PubMed ID: 17084815
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
