BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

144 related articles for article (PubMed ID: 27158141)

  • 21. Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship.
    Christensen MK; Erichsen KD; Olesen UH; Tjørnelund J; Fristrup P; Thougaard A; Nielsen SJ; Sehested M; Jensen PB; Loza E; Kalvinsh I; Garten A; Kiess W; Björkling F
    J Med Chem; 2013 Nov; 56(22):9071-88. PubMed ID: 24164086
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.
    Akiu M; Tsuji T; Sogawa Y; Terayama K; Yokoyama M; Tanaka J; Asano D; Sakurai K; Sergienko E; Sessions EH; Gardell SJ; Pinkerton AB; Nakamura T
    Bioorg Med Chem Lett; 2021 Jul; 43():128048. PubMed ID: 33887438
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Nicotinamide phosphoribosyltransferase is a molecular target of potent anticancer agents identified from phenotype-based drug screening.
    Yamaguchi D; Imaizumi T; Yagi K; Matsumoto Y; Nakashima T; Hirose A; Kashima N; Nosaka Y; Hamada T; Okawa K; Nishiya Y; Kubo K
    Sci Rep; 2019 May; 9(1):7742. PubMed ID: 31123329
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase.
    Zabka TS; Singh J; Dhawan P; Liederer BM; Oeh J; Kauss MA; Xiao Y; Zak M; Lin T; McCray B; La N; Nguyen T; Beyer J; Farman C; Uppal H; Dragovich PS; O'Brien T; Sampath D; Misner DL
    Toxicol Sci; 2015 Mar; 144(1):163-72. PubMed ID: 25505128
    [TBL] [Abstract][Full Text] [Related]  

  • 25. A Red-Light-Activated Ruthenium-Caged NAMPT Inhibitor Remains Phototoxic in Hypoxic Cancer Cells.
    Lameijer LN; Ernst D; Hopkins SL; Meijer MS; Askes SHC; Le Dévédec SE; Bonnet S
    Angew Chem Int Ed Engl; 2017 Sep; 56(38):11549-11553. PubMed ID: 28666065
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Fragment-based identification of amides derived from trans-2-(pyridin-3-yl)cyclopropanecarboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
    Giannetti AM; Zheng X; Skelton NJ; Wang W; Bravo BJ; Bair KW; Baumeister T; Cheng E; Crocker L; Feng Y; Gunzner-Toste J; Ho YC; Hua R; Liederer BM; Liu Y; Ma X; O'Brien T; Oeh J; Sampath D; Shen Y; Wang C; Wang L; Wu H; Xiao Y; Yuen PW; Zak M; Zhao G; Zhao Q; Dragovich PS
    J Med Chem; 2014 Feb; 57(3):770-92. PubMed ID: 24405419
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Discovery of a novel nicotinamide phosphoribosyl transferase (NAMPT) inhibitor via in silico screening.
    Takeuchi M; Niimi T; Masumoto M; Orita M; Yokota H; Yamamoto T
    Biol Pharm Bull; 2014; 37(1):31-6. PubMed ID: 24389478
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Targeting NAMPT for Therapeutic Intervention in Cancer and Inflammation: Structure-Based Drug Design and Biological Screening.
    Pulla VK; Sriram DS; Soni V; Viswanadha S; Sriram D; Yogeeswari P
    Chem Biol Drug Des; 2015 Oct; 86(4):881-94. PubMed ID: 25850461
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.
    Dong G; Chen W; Wang X; Yang X; Xu T; Wang P; Zhang W; Rao Y; Miao C; Sheng C
    J Med Chem; 2017 Oct; 60(19):7965-7983. PubMed ID: 28885834
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors.
    Sadrerafi K; Mason EO; Lee MW
    Drug Des Devel Ther; 2018; 12():987-995. PubMed ID: 29731606
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
    Zheng X; Bauer P; Baumeister T; Buckmelter AJ; Caligiuri M; Clodfelter KH; Han B; Ho YC; Kley N; Lin J; Reynolds DJ; Sharma G; Smith CC; Wang Z; Dragovich PS; Gunzner-Toste J; Liederer BM; Ly J; O'Brien T; Oh A; Wang L; Wang W; Xiao Y; Zak M; Zhao G; Yuen PW; Bair KW
    J Med Chem; 2013 Aug; 56(16):6413-33. PubMed ID: 23859118
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Identification of small-molecule urea derivatives as novel NAMPT inhibitors via pharmacophore-based virtual screening.
    Ozgencil F; Eren G; Ozkan Y; Guntekin-Ergun S; Cetin-Atalay R
    Bioorg Med Chem; 2020 Jan; 28(1):115217. PubMed ID: 31818629
    [TBL] [Abstract][Full Text] [Related]  

  • 33. A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase.
    Zhang RY; Qin Y; Lv XQ; Wang P; Xu TY; Zhang L; Miao CY
    Anal Biochem; 2011 May; 412(1):18-25. PubMed ID: 21211508
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
    Zheng X; Bauer P; Baumeister T; Buckmelter AJ; Caligiuri M; Clodfelter KH; Han B; Ho YC; Kley N; Lin J; Reynolds DJ; Sharma G; Smith CC; Wang Z; Dragovich PS; Oh A; Wang W; Zak M; Gunzner-Toste J; Zhao G; Yuen PW; Bair KW
    J Med Chem; 2013 Jun; 56(12):4921-37. PubMed ID: 23617784
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.
    Galli U; Travelli C; Massarotti A; Fakhfouri G; Rahimian R; Tron GC; Genazzani AA
    J Med Chem; 2013 Aug; 56(16):6279-96. PubMed ID: 23679915
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities.
    Chen H; Wang S; Zhang H; Nice EC; Huang C
    Expert Rev Anticancer Ther; 2016 Aug; 16(8):827-38. PubMed ID: 27186719
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Crystal structure-based comparison of two NAMPT inhibitors.
    Zhang SL; Xu TY; Yang ZL; Han S; Zhao Q; Miao CY
    Acta Pharmacol Sin; 2018 Feb; 39(2):294-301. PubMed ID: 28858298
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Improved synthesis of MC4-PPEA and the biological evaluation of its hydroxymethyl derivative.
    Sadrerafi K; Zargham EO; Lee MW
    Bioorg Med Chem Lett; 2016 Jan; 26(2):618-621. PubMed ID: 26681512
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair.
    Piacente F; Caffa I; Ravera S; Sociali G; Passalacqua M; Vellone VG; Becherini P; Reverberi D; Monacelli F; Ballestrero A; Odetti P; Cagnetta A; Cea M; Nahimana A; Duchosal M; Bruzzone S; Nencioni A
    Cancer Res; 2017 Jul; 77(14):3857-3869. PubMed ID: 28507103
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Structural basis for resistance to diverse classes of NAMPT inhibitors.
    Wang W; Elkins K; Oh A; Ho YC; Wu J; Li H; Xiao Y; Kwong M; Coons M; Brillantes B; Cheng E; Crocker L; Dragovich PS; Sampath D; Zheng X; Bair KW; O'Brien T; Belmont LD
    PLoS One; 2014; 9(10):e109366. PubMed ID: 25285661
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.