BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

243 related articles for article (PubMed ID: 27159560)

  • 1. Allosteric inhibition of antiapoptotic MCL-1.
    Lee S; Wales TE; Escudero S; Cohen DT; Luccarelli J; Gallagher CG; Cohen NA; Huhn AJ; Bird GH; Engen JR; Walensky LD
    Nat Struct Mol Biol; 2016 Jun; 23(6):600-7. PubMed ID: 27159560
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular dynamics study of segment peptides of Bax, Bim, and Mcl-1 BH3 domain of the apoptosis-regulating proteins bound to the anti-apoptotic Mcl-1 protein.
    Zhao RN; Fan S; Han JG; Liu G
    J Biomol Struct Dyn; 2015; 33(5):1067-81. PubMed ID: 24865469
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Binding affinity of pro-apoptotic BH3 peptides for the anti-apoptotic Mcl-1 and A1 proteins: Molecular dynamics simulations of Mcl-1 and A1 in complex with six different BH3 peptides.
    Modi V; Sankararamakrishnan R
    J Mol Graph Model; 2017 May; 73():115-128. PubMed ID: 28279820
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.
    Day CL; Chen L; Richardson SJ; Harrison PJ; Huang DC; Hinds MG
    J Biol Chem; 2005 Feb; 280(6):4738-44. PubMed ID: 15550399
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.
    Liu Y; Xie M; Song T; Sheng H; Yu X; Zhang Z
    Pigment Cell Melanoma Res; 2015 Mar; 28(2):161-70. PubMed ID: 25324174
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Toward Understanding Mcl-1 Promiscuous and Specific Binding Mode.
    Fogha J; Marekha B; De Giorgi M; Voisin-Chiret AS; Rault S; Bureau R; Sopkova-de Oliveira Santos J
    J Chem Inf Model; 2017 Nov; 57(11):2885-2895. PubMed ID: 29016132
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode.
    Hedir S; De Giorgi M; Fogha J; De Pascale M; Weiswald LB; Brotin E; Marekha B; Denoyelle C; Denis C; Suzanne P; Gautier F; Juin P; Ligat L; Lopez F; Carlier L; Legay R; Bureau R; Rault S; Poulain L; Oliveira Santos JS; Voisin-Chiret AS
    Eur J Med Chem; 2018 Nov; 159():357-380. PubMed ID: 30308410
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1.
    Weber A; Ausländer D; Häcker G
    Apoptosis; 2013 Sep; 18(9):1093-105. PubMed ID: 23733106
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes.
    Fire E; Gullá SV; Grant RA; Keating AE
    Protein Sci; 2010 Mar; 19(3):507-19. PubMed ID: 20066663
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers.
    Modugno M; Banfi P; Gasparri F; Borzilleri R; Carter P; Cornelius L; Gottardis M; Lee V; Mapelli C; Naglich JG; Tebben A; Vite G; Pastori W; Albanese C; Corti E; Ballinari D; Galvani A
    Exp Cell Res; 2015 Mar; 332(2):267-77. PubMed ID: 25486070
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1.
    Zhang Z; Song T; Zhang T; Gao J; Wu G; An L; Du G
    Int J Cancer; 2011 Apr; 128(7):1724-35. PubMed ID: 20503275
    [TBL] [Abstract][Full Text] [Related]  

  • 12. BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members.
    Hsu SY; Lin P; Hsueh AJ
    Mol Endocrinol; 1998 Sep; 12(9):1432-40. PubMed ID: 9731710
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems.
    Etxebarria A; Landeta O; Antonsson B; Basañez G
    Biochem Pharmacol; 2008 Dec; 76(11):1563-76. PubMed ID: 18762177
    [TBL] [Abstract][Full Text] [Related]  

  • 14. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.
    Kuwana T; Bouchier-Hayes L; Chipuk JE; Bonzon C; Sullivan BA; Green DR; Newmeyer DD
    Mol Cell; 2005 Feb; 17(4):525-35. PubMed ID: 15721256
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70.
    Stankiewicz AR; Livingstone AM; Mohseni N; Mosser DD
    Cell Death Differ; 2009 Apr; 16(4):638-47. PubMed ID: 19148187
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular docking studies of bioactive compounds from Annona muricata Linn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins.
    Mohamad Rosdi MN; Mohd Arif S; Abu Bakar MH; Razali SA; Mohamed Zulkifli R; Ya'akob H
    Apoptosis; 2018 Jan; 23(1):27-40. PubMed ID: 29204721
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo.
    Abulwerdi F; Liao C; Liu M; Azmi AS; Aboukameel A; Mady AS; Gulappa T; Cierpicki T; Owens S; Zhang T; Sun D; Stuckey JA; Mohammad RM; Nikolovska-Coleska Z
    Mol Cancer Ther; 2014 Mar; 13(3):565-75. PubMed ID: 24019208
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
    van Delft MF; Wei AH; Mason KD; Vandenberg CJ; Chen L; Czabotar PE; Willis SN; Scott CL; Day CL; Cory S; Adams JM; Roberts AW; Huang DC
    Cancer Cell; 2006 Nov; 10(5):389-99. PubMed ID: 17097561
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival.
    Cohen NA; Stewart ML; Gavathiotis E; Tepper JL; Bruekner SR; Koss B; Opferman JT; Walensky LD
    Chem Biol; 2012 Sep; 19(9):1175-86. PubMed ID: 22999885
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mapping the BH3 Binding Interface of Bcl-xL, Bcl-2, and Mcl-1 Using Split-Luciferase Reassembly.
    Campbell ST; Carlson KJ; Buchholz CJ; Helmers MR; Ghosh I
    Biochemistry; 2015 Apr; 54(16):2632-43. PubMed ID: 25844633
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.