185 related articles for article (PubMed ID: 27168215)
1. Changing the selectivity profile - from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors.
Maiwald A; Hammami M; Wagner S; Heine A; Klebe G; Steinmetzer T
J Enzyme Inhib Med Chem; 2016; 31(sup1):89-97. PubMed ID: 27168215
[TBL] [Abstract][Full Text] [Related]
2. Evaluation of bisbenzamidines as inhibitors for matriptase-2.
Beckmann AM; Gilberg E; Gattner S; Huang TL; Vanden Eynde JJ; Mayence A; Bajorath J; Stirnberg M; Gütschow M
Bioorg Med Chem Lett; 2016 Aug; 26(15):3741-5. PubMed ID: 27287367
[TBL] [Abstract][Full Text] [Related]
3. Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines.
Dosa S; Stirnberg M; Lülsdorff V; Häußler D; Maurer E; Gütschow M
Bioorg Med Chem; 2012 Nov; 20(21):6489-505. PubMed ID: 23026080
[TBL] [Abstract][Full Text] [Related]
4. Improving the selectivity of 3-amidinophenylalanine-derived matriptase inhibitors.
Pilgram O; Keils A; Benary GE; Müller J; Merkl S; Ngaha S; Huber S; Chevillard F; Harbig A; Magdolen V; Heine A; Böttcher-Friebertshäuser E; Steinmetzer T
Eur J Med Chem; 2022 Aug; 238():114437. PubMed ID: 35635944
[TBL] [Abstract][Full Text] [Related]
5. Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.
Enyedy IJ; Lee SL; Kuo AH; Dickson RB; Lin CY; Wang S
J Med Chem; 2001 Apr; 44(9):1349-55. PubMed ID: 11311057
[TBL] [Abstract][Full Text] [Related]
6. Heterocyclic core analogs of a direct thrombin inhibitor.
Blizzard TA; Singh S; Patil B; Chidurala N; Komanduri V; Debnath S; Belyakov S; Crespo A; Struck A; Kurtz M; Wiltsie J; Shen X; Sonatore L; Arocho M; Lewis D; Ogletree M; Biftu T
Bioorg Med Chem Lett; 2014 Feb; 24(4):1111-5. PubMed ID: 24461292
[TBL] [Abstract][Full Text] [Related]
7. Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors.
Schweinitz A; Dönnecke D; Ludwig A; Steinmetzer P; Schulze A; Kotthaus J; Wein S; Clement B; Steinmetzer T
Bioorg Med Chem Lett; 2009 Apr; 19(7):1960-5. PubMed ID: 19250826
[TBL] [Abstract][Full Text] [Related]
8. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
Katz BA; Elrod K; Luong C; Rice MJ; Mackman RL; Sprengeler PA; Spencer J; Hataye J; Janc J; Link J; Litvak J; Rai R; Rice K; Sideris S; Verner E; Young W
J Mol Biol; 2001 Apr; 307(5):1451-86. PubMed ID: 11292354
[TBL] [Abstract][Full Text] [Related]
9. Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies.
Sperl S; Bergner A; Stürzebecher J; Magdolen V; Bode W; Moroder L
Biol Chem; 2000 Apr; 381(4):321-9. PubMed ID: 10839461
[TBL] [Abstract][Full Text] [Related]
10. Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin.
Stubbs MT; Huber R; Bode W
FEBS Lett; 1995 Nov; 375(1-2):103-7. PubMed ID: 7498454
[TBL] [Abstract][Full Text] [Related]
11. α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer.
Han Z; Harris PK; Karmakar P; Kim T; Owusu BY; Wildman SA; Klampfer L; Janetka JW
ChemMedChem; 2016 Mar; 11(6):585-99. PubMed ID: 26889658
[TBL] [Abstract][Full Text] [Related]
12. Comparative molecular modeling analysis of-5-amidinoindole and benzamidine binding to thrombin and trypsin: specific H-bond formation contributes to high 5-amidinoindole potency and selectivity for thrombin and factor Xa.
Zhou Y; Johnson ME
J Mol Recognit; 1999; 12(4):235-41. PubMed ID: 10440994
[TBL] [Abstract][Full Text] [Related]
13. Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics.
Marinko P; Krbavcic A; Mlinsek G; Solmajer T; Bakija AT; Stegnar M; Stojan J; Kikelj D
Eur J Med Chem; 2004 Mar; 39(3):257-65. PubMed ID: 15051174
[TBL] [Abstract][Full Text] [Related]
14. Structure-based design of potent, amidine-derived inhibitors of factor Xa: evaluation of selectivity, anticoagulant activity, and antithrombotic activity.
Wiley MR; Weir LC; Briggs S; Bryan NA; Buben J; Campbell C; Chirgadze NY; Conrad RC; Craft TJ; Ficorilli JV; Franciskovich JB; Froelich LL; Gifford-Moore DS; Goodson T; Herron DK; Klimkowski VJ; Kurz KD; Kyle JA; Masters JJ; Ratz AM; Milot G; Shuman RT; Smith T; Smith GF; Tebbe AL; Tinsley JM
J Med Chem; 2000 Mar; 43(5):883-99. PubMed ID: 10715155
[TBL] [Abstract][Full Text] [Related]
15. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
Bhunia SS; Roy KK; Saxena AK
J Chem Inf Model; 2011 Aug; 51(8):1966-85. PubMed ID: 21761917
[TBL] [Abstract][Full Text] [Related]
16. Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.
St-Georges C; Désilets A; Béliveau F; Ghinet M; Dion SP; Colombo É; Boudreault PL; Najmanovich RJ; Leduc R; Marsault É
Eur J Med Chem; 2017 Mar; 129():110-123. PubMed ID: 28219045
[TBL] [Abstract][Full Text] [Related]
17. A Bisbenzamidine Phosphonate as a Janus-faced Inhibitor for Trypsin-like Serine Proteases.
Häußler D; Scheidt T; Stirnberg M; Steinmetzer T; Gütschow M
ChemMedChem; 2015 Oct; 10(10):1641-6. PubMed ID: 26306030
[TBL] [Abstract][Full Text] [Related]
18. Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets.
Franco FM; Jones DE; Harris PK; Han Z; Wildman SA; Jarvis CM; Janetka JW
Bioorg Med Chem; 2015 May; 23(10):2328-43. PubMed ID: 25882520
[TBL] [Abstract][Full Text] [Related]
19. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
[TBL] [Abstract][Full Text] [Related]
20. A novel factor Xa inhibitor: structure-activity relationships and selectivity between factor Xa and thrombin.
Katakura S; Nagahara T; Hara T; Iwamoto M
Biochem Biophys Res Commun; 1993 Dec; 197(2):965-72. PubMed ID: 8267636
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
