BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

181 related articles for article (PubMed ID: 27185330)

  • 1. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.
    Wood MR; Noetzel MJ; Engers JL; Bollinger KA; Melancon BJ; Tarr JC; Han C; West M; Gregro AR; Lamsal A; Chang S; Ajmera S; Smith E; Chase P; Hodder PS; Bubser M; Jones CK; Hopkins CR; Emmitte KA; Niswender CM; Wood MW; Duggan ME; Conn PJ; Bridges TM; Lindsley CW
    Bioorg Med Chem Lett; 2016 Jul; 26(13):3029-3033. PubMed ID: 27185330
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery of a novel, CNS penetrant M
    Bewley BR; Spearing PK; Weiner RL; Luscombe VB; Zhan X; Chang S; Cho HP; Rodriguez AL; Niswender CM; Conn PJ; Bridges TM; Engers DW; Lindsley CW
    Bioorg Med Chem Lett; 2017 Sep; 27(18):4274-4279. PubMed ID: 28866269
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.
    Wood MR; Noetzel MJ; Tarr JC; Rodriguez AL; Lamsal A; Chang S; Foster JJ; Smith E; Chase P; Hodder PS; Engers DW; Niswender CM; Brandon NJ; Wood MW; Duggan ME; Conn PJ; Bridges TM; Lindsley CW
    Bioorg Med Chem Lett; 2016 Sep; 26(17):4282-6. PubMed ID: 27476142
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Challenges in the development of an M
    Wood MR; Noetzel MJ; Poslusney MS; Melancon BJ; Tarr JC; Lamsal A; Chang S; Luscombe VB; Weiner RL; Cho HP; Bubser M; Jones CK; Niswender CM; Wood MW; Engers DW; Brandon NJ; Duggan ME; Conn PJ; Bridges TM; Lindsley CW
    Bioorg Med Chem Lett; 2017 Jan; 27(2):171-175. PubMed ID: 27939174
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of structurally distinct tricyclic M
    Long MF; Capstick RA; Spearing PK; Engers JL; Gregro AR; Bollinger SR; Chang S; Luscombe VB; Rodriguez AL; Cho HP; Niswender CM; Bridges TM; Conn PJ; Lindsley CW; Engers DW; Temple KJ
    Bioorg Med Chem Lett; 2021 Dec; 53():128416. PubMed ID: 34710625
    [TBL] [Abstract][Full Text] [Related]  

  • 6. SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M
    Chopko TC; Han C; Gregro AR; Engers DW; Felts AS; Poslusney MS; Bollinger KA; Morrison RD; Bubser M; Lamsal A; Luscombe VB; Cho HP; Schnetz-Boutaud NC; Rodriguez AL; Chang S; Daniels JS; Stec DF; Niswender CM; Jones CK; Wood MR; Wood MW; Duggan ME; Brandon NJ; Conn PJ; Bridges TM; Lindsley CW; Melancon BJ
    Bioorg Med Chem Lett; 2019 Aug; 29(16):2224-2228. PubMed ID: 31248774
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists.
    Bender AM; Weiner RL; Luscombe VB; Ajmera S; Cho HP; Chang S; Zhan X; Rodriguez AL; Niswender CM; Engers DW; Bridges TM; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2017 Aug; 27(15):3576-3581. PubMed ID: 28633897
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.
    Bender AM; Weiner RL; Luscombe VB; Cho HP; Niswender CM; Engers DW; Bridges TM; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2017 Jun; 27(11):2479-2483. PubMed ID: 28427812
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M
    Long MF; Engers JL; Chang S; Zhan X; Weiner RL; Luscombe VB; Rodriguez AL; Cho HP; Niswender CM; Bridges TM; Conn PJ; Engers DW; Lindsley CW
    Bioorg Med Chem Lett; 2017 Nov; 27(22):4999-5001. PubMed ID: 29037946
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and Optimization of Potent and CNS Penetrant M
    Bender AM; Cho HP; Nance KD; Lingenfelter KS; Luscombe VB; Gentry PR; Voigtritter K; Berizzi AE; Sexton PM; Langmead CJ; Christopoulos A; Locuson CW; Bridges TM; Chang S; O'Neill JC; Zhan X; Niswender CM; Jones CK; Conn PJ; Lindsley CW
    ACS Chem Neurosci; 2018 Jul; 9(7):1572-1581. PubMed ID: 29678111
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Challenges in the development of an M
    Tarr JC; Wood MR; Noetzel MJ; Bertron JL; Weiner RL; Rodriguez AL; Lamsal A; Byers FW; Chang S; Cho HP; Jones CK; Niswender CM; Wood MW; Brandon NJ; Duggan ME; Conn PJ; Bridges TM; Lindsley CW
    Bioorg Med Chem Lett; 2017 Jul; 27(13):2990-2995. PubMed ID: 28522253
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of structurally distinct tricyclic M
    Temple KJ; Long MF; Engers JL; Watson KJ; Chang S; Luscombe VB; Rodriguez AL; Niswender CM; Bridges TM; Conn PJ; Engers DW; Lindsley CW
    Bioorg Med Chem Lett; 2020 Feb; 30(4):126811. PubMed ID: 31787491
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery, Optimization, and Biological Characterization of 2,3,6-Trisubstituted Pyridine-Containing M
    Schubert JW; Harrison ST; Mulhearn J; Gomez R; Tynebor R; Jones K; Bunda J; Hanney B; Wai JM; Cox C; McCauley JA; Sanders JM; Magliaro B; O'Brien J; Pajkovic N; Huszar Agrapides SL; Taylor A; Gotter A; Smith SM; Uslaner J; Browne S; Risso S; Egbertson M
    ChemMedChem; 2019 May; 14(9):943-951. PubMed ID: 30920765
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Challenges in the development of an M
    Tarr JC; Wood MR; Noetzel MJ; Melancon BJ; Lamsal A; Luscombe VB; Rodriguez AL; Byers FW; Chang S; Cho HP; Engers DW; Jones CK; Niswender CM; Wood MW; Brandon NJ; Duggan ME; Conn PJ; Bridges TM; Lindsley CW
    Bioorg Med Chem Lett; 2017 Dec; 27(23):5179-5184. PubMed ID: 29089231
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M
    Temple KJ; Engers JL; Long MF; Watson KJ; Chang S; Luscombe VB; Jenkins MT; Rodriguez AL; Niswender CM; Bridges TM; Conn PJ; Engers DW; Lindsley CW
    Bioorg Med Chem Lett; 2020 Feb; 30(3):126812. PubMed ID: 31784320
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.
    Bubser M; Bridges TM; Dencker D; Gould RW; Grannan M; Noetzel MJ; Lamsal A; Niswender CM; Daniels JS; Poslusney MS; Melancon BJ; Tarr JC; Byers FW; Wess J; Duggan ME; Dunlop J; Wood MW; Brandon NJ; Wood MR; Lindsley CW; Conn PJ; Jones CK
    ACS Chem Neurosci; 2014 Oct; 5(10):920-42. PubMed ID: 25137629
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor.
    Huynh T; Valant C; Crosby IT; Sexton PM; Christopoulos A; Capuano B
    J Med Chem; 2013 Oct; 56(20):8196-200. PubMed ID: 24074052
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Optimization of M
    Melancon BJ; Wood MR; Noetzel MJ; Nance KD; Engelberg EM; Han C; Lamsal A; Chang S; Cho HP; Byers FW; Bubser M; Jones CK; Niswender CM; Wood MW; Engers DW; Wu D; Brandon NJ; Duggan ME; Conn PJ; Bridges TM; Lindsley CW
    Bioorg Med Chem Lett; 2017 Jun; 27(11):2296-2301. PubMed ID: 28442253
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
    Le U; Melancon BJ; Bridges TM; Vinson PN; Utley TJ; Lamsal A; Rodriguez AL; Venable D; Sheffler DJ; Jones CK; Blobaum AL; Wood MR; Daniels JS; Conn PJ; Niswender CM; Lindsley CW; Hopkins CR
    Bioorg Med Chem Lett; 2013 Jan; 23(1):346-50. PubMed ID: 23177787
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration.
    Panarese JD; Cho HP; Adams JJ; Nance KD; Garcia-Barrantes PM; Chang S; Morrison RD; Blobaum AL; Niswender CM; Stauffer SR; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2016 Aug; 26(15):3822-5. PubMed ID: 27173801
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.