BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

217 related articles for article (PubMed ID: 27196744)

  • 1. Loss of presenilin function is associated with a selective gain of APP function.
    Deyts C; Clutter M; Herrera S; Jovanovic N; Goddi A; Parent AT
    Elife; 2016 May; 5():. PubMed ID: 27196744
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.
    Gandy S; Zhang YW; Ikin A; Schmidt SD; Bogush A; Levy E; Sheffield R; Nixon RA; Liao FF; Mathews PM; Xu H; Ehrlich ME
    J Neurochem; 2007 Aug; 102(3):619-26. PubMed ID: 17630980
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
    Kumar VB; Franko M; Banks WA; Kasinadhuni P; Farr SA; Vyas K; Choudhuri V; Morley JE
    J Exp Biol; 2009 Feb; 212(Pt 4):494-8. PubMed ID: 19181896
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP.
    Robinson A; Grösgen S; Mett J; Zimmer VC; Haupenthal VJ; Hundsdörfer B; Stahlmann CP; Slobodskoy Y; Müller UC; Hartmann T; Stein R; Grimm MO
    Aging Cell; 2014 Apr; 13(2):263-72. PubMed ID: 24304563
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
    Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.
    Berezovska O; Lleo A; Herl LD; Frosch MP; Stern EA; Bacskai BJ; Hyman BT
    J Neurosci; 2005 Mar; 25(11):3009-17. PubMed ID: 15772361
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.
    Sato N; Okochi M; Shinohara M; Thinakaran G; Takeda S; Fukumori A; Shinohara-Noma M; Mori-Ueda M; Hamada H; Takeda M; Rakugi H; Morishita R
    PLoS One; 2012; 7(11):e48551. PubMed ID: 23152781
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Elevated cellular cholesterol in Familial Alzheimer's presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein.
    Cho YY; Kwon OH; Park MK; Kim TW; Chung S
    PLoS One; 2019; 14(1):e0210535. PubMed ID: 30682043
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of presenilin-1 familial Alzheimer's disease mutations on γ-secretase activation for cleavage of amyloid precursor protein.
    Do HN; Devkota S; Bhattarai A; Wolfe MS; Miao Y
    Commun Biol; 2023 Feb; 6(1):174. PubMed ID: 36788318
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage.
    Zhang C; Browne A; Kim DY; Tanzi RE
    Curr Alzheimer Res; 2010 Feb; 7(1):21-6. PubMed ID: 20205669
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
    Walker ES; Martinez M; Brunkan AL; Goate A
    J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic Mice.
    Zhao FL; Qiao PF; Yan N; Gao D; Liu MJ; Yan Y
    Neurochem Res; 2016 May; 41(5):1145-59. PubMed ID: 26708452
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
    De Strooper B; Saftig P; Craessaerts K; Vanderstichele H; Guhde G; Annaert W; Von Figura K; Van Leuven F
    Nature; 1998 Jan; 391(6665):387-90. PubMed ID: 9450754
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.
    Leroy K; Ando K; Laporte V; Dedecker R; Suain V; Authelet M; Héraud C; Pierrot N; Yilmaz Z; Octave JN; Brion JP
    Am J Pathol; 2012 Dec; 181(6):1928-40. PubMed ID: 23026200
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.
    Ryazantseva M; Skobeleva K; Glushankova L; Kaznacheyeva E
    J Neurochem; 2016 Mar; 136(5):1085-95. PubMed ID: 26678016
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
    Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
    [TBL] [Abstract][Full Text] [Related]  

  • 17. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
    Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
    Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.
    Mamada N; Tanokashira D; Ishii K; Tamaoka A; Araki W
    Biochem Biophys Res Commun; 2017 Apr; 486(2):321-328. PubMed ID: 28302486
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.
    Woodruff G; Young JE; Martinez FJ; Buen F; Gore A; Kinaga J; Li Z; Yuan SH; Zhang K; Goldstein LS
    Cell Rep; 2013 Nov; 5(4):974-85. PubMed ID: 24239350
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
    J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.