71 related articles for article (PubMed ID: 27209231)
1. Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor.
Yoon S; Kim JH; Yoon I; Kim C; Kim SE; Koh Y; Jeong SJ; Lee J; Kim S; Lee J
Bioorg Med Chem Lett; 2016 Jul; 26(13):3038-3041. PubMed ID: 27209231
[TBL] [Abstract][Full Text] [Related]
2. Discovery of Leucyladenylate Sulfamates as Novel Leucyl-tRNA Synthetase (LRS)-Targeted Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitors.
Yoon S; Kim JH; Kim SE; Kim C; Tran PT; Ann J; Koh Y; Jang J; Kim S; Moon HS; Kim WK; Lee S; Lee J; Kim S; Lee J
J Med Chem; 2016 Nov; 59(22):10322-10328. PubMed ID: 27933890
[TBL] [Abstract][Full Text] [Related]
3. Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S; Kim JH; Koh Y; Tran PT; Ann J; Yoon I; Jang J; Kim WK; Lee S; Lee J; Kim S; Lee J
Bioorg Med Chem; 2017 Aug; 25(15):4145-4152. PubMed ID: 28625715
[TBL] [Abstract][Full Text] [Related]
4. Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Yoon S; Zuo D; Kim JH; Yoon I; Ann J; Kim SE; Cho D; Kim WK; Lee S; Lee J; Kim S; Lee J
Bioorg Med Chem; 2018 Aug; 26(14):4073-4079. PubMed ID: 30041947
[TBL] [Abstract][Full Text] [Related]
5. Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.
Kim JH; Lee C; Lee M; Wang H; Kim K; Park SJ; Yoon I; Jang J; Zhao H; Kim HK; Kwon NH; Jeong SJ; Yoo HC; Kim JH; Yang JS; Lee MY; Lee CW; Yun J; Oh SJ; Kang JS; Martinis SA; Hwang KY; Guo M; Han G; Han JM; Kim S
Nat Commun; 2017 Sep; 8(1):732. PubMed ID: 28963468
[TBL] [Abstract][Full Text] [Related]
6. Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.
Choi H; Son JB; Kang J; Kwon J; Kim JH; Jung M; Kim SK; Kim S; Mun JY
Biochem Biophys Res Commun; 2017 Nov; 493(2):1129-1135. PubMed ID: 28882589
[TBL] [Abstract][Full Text] [Related]
7. Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).
Yoon S; Kim SE; Kim JH; Yoon I; Tran PT; Ann J; Kim C; Byun WS; Lee S; Kim S; Lee J; Lee J
Bioorg Med Chem; 2019 Mar; 27(6):1099-1109. PubMed ID: 30755350
[TBL] [Abstract][Full Text] [Related]
8. GSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.
Ito H; Ichiyanagi O; Naito S; Bilim VN; Tomita Y; Kato T; Nagaoka A; Tsuchiya N
BMC Cancer; 2016 Jul; 16():393. PubMed ID: 27387559
[TBL] [Abstract][Full Text] [Related]
9. Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.
Lee M; Kim JH; Yoon I; Lee C; Fallahi Sichani M; Kang JS; Kang J; Guo M; Lee KY; Han G; Kim S; Han JM
Proc Natl Acad Sci U S A; 2018 Jun; 115(23):E5279-E5288. PubMed ID: 29784813
[TBL] [Abstract][Full Text] [Related]
10. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.
Han JM; Jeong SJ; Park MC; Kim G; Kwon NH; Kim HK; Ha SH; Ryu SH; Kim S
Cell; 2012 Apr; 149(2):410-24. PubMed ID: 22424946
[TBL] [Abstract][Full Text] [Related]
11. Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: a tale of two complexes.
Jhanwar-Uniyal M; Gillick JL; Neil J; Tobias M; Thwing ZE; Murali R
Adv Biol Regul; 2015 Jan; 57():64-74. PubMed ID: 25442674
[TBL] [Abstract][Full Text] [Related]
12. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner.
Roffé M; Lupinacci FC; Soares LC; Hajj GN; Martins VR
Cell Signal; 2015 Aug; 27(8):1630-42. PubMed ID: 25889895
[TBL] [Abstract][Full Text] [Related]
13. Therapeutic effects of the novel Leucyl-tRNA synthetase inhibitor BC-LI-0186 in non-small cell lung cancer.
Kim EY; Lee JG; Lee JM; Kim A; Yoo HC; Kim K; Lee M; Lee C; Han G; Han JM; Chang YS
Ther Adv Med Oncol; 2019; 11():1758835919846798. PubMed ID: 31205503
[TBL] [Abstract][Full Text] [Related]
14. mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress.
Li J; Shin S; Sun Y; Yoon SO; Li C; Zhang E; Yu J; Zhang J; Blenis J
Cancer Res; 2016 Aug; 76(16):4816-27. PubMed ID: 27197195
[TBL] [Abstract][Full Text] [Related]
15. Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling.
Yoon MS; Son K; Arauz E; Han JM; Kim S; Chen J
Cell Rep; 2016 Aug; 16(6):1510-1517. PubMed ID: 27477288
[TBL] [Abstract][Full Text] [Related]
16. mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo.
Zhang Y; Xu S; Lin J; Yao G; Han Z; Liang B; Zou Z; Chen Z; Song Q; Dai Y; Gao T; Liu A; Bai X
Breast Cancer Res Treat; 2012 Nov; 136(2):379-88. PubMed ID: 23053656
[TBL] [Abstract][Full Text] [Related]
17. Potentiation of Growth Inhibitory Responses of the mTOR Inhibitor Everolimus by Dual mTORC1/2 Inhibitors in Cultured Breast Cancer Cell Lines.
Leung EY; Askarian-Amiri M; Finlay GJ; Rewcastle GW; Baguley BC
PLoS One; 2015; 10(7):e0131400. PubMed ID: 26148118
[TBL] [Abstract][Full Text] [Related]
18. P7170, a novel inhibitor of mTORC1/mTORC2 and Activin receptor-like Kinase 1 (ALK1) inhibits the growth of non small cell lung cancer.
Venkatesha VA; Joshi A; Venkataraman M; Sonawane V; Bhatia D; Tannu P; Bose J; Choudhari S; Srivastava A; Pandey PK; Lad VJ; Sangana R; Ahmed T; Damre A; Deore V; Sahu B; Kumar S; Sharma S; Agarwal VR
Mol Cancer; 2014 Dec; 13():259. PubMed ID: 25466244
[TBL] [Abstract][Full Text] [Related]
19. Leucyl-tRNA synthetase: double duty in amino acid sensing.
Durán RV; Hall MN
Cell Res; 2012 Aug; 22(8):1207-9. PubMed ID: 22525334
[TBL] [Abstract][Full Text] [Related]
20. Autophagy inhibition sensitizes WYE-354-induced anti-colon cancer activity in vitro and in vivo.
Wang L; Zhu YR; Wang S; Zhao S
Tumour Biol; 2016 Sep; 37(9):11743-11752. PubMed ID: 27020593
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
