BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

249 related articles for article (PubMed ID: 27227314)

  • 1. Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.
    Feldman HC; Tong M; Wang L; Meza-Acevedo R; Gobillot TA; Lebedev I; Gliedt MJ; Hari SB; Mitra AK; Backes BJ; Papa FR; Seeliger MA; Maly DJ
    ACS Chem Biol; 2016 Aug; 11(8):2195-205. PubMed ID: 27227314
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.
    Ghosh R; Wang L; Wang ES; Perera BG; Igbaria A; Morita S; Prado K; Thamsen M; Caswell D; Macias H; Weiberth KF; Gliedt MJ; Alavi MV; Hari SB; Mitra AK; Bhhatarai B; Schürer SC; Snapp EL; Gould DB; German MS; Backes BJ; Maly DJ; Oakes SA; Papa FR
    Cell; 2014 Jul; 158(3):534-48. PubMed ID: 25018104
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Profiling the Dual Enzymatic Activities of the Serine/Threonine Kinase IRE1α.
    Feldman HC; Maly DJ
    Methods Mol Biol; 2017; 1513():233-242. PubMed ID: 27807842
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands.
    Ferri E; Le Thomas A; Wallweber HA; Day ES; Walters BT; Kaufman SE; Braun MG; Clark KR; Beresini MH; Mortara K; Chen YA; Canter B; Phung W; Liu PS; Lammens A; Ashkenazi A; Rudolph J; Wang W
    Nat Commun; 2020 Dec; 11(1):6387. PubMed ID: 33318494
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
    Concha NO; Smallwood A; Bonnette W; Totoritis R; Zhang G; Federowicz K; Yang J; Qi H; Chen S; Campobasso N; Choudhry AE; Shuster LE; Evans KA; Ralph J; Sweitzer S; Heerding DA; Buser CA; Su DS; DeYoung MP
    Mol Pharmacol; 2015 Dec; 88(6):1011-23. PubMed ID: 26438213
    [TBL] [Abstract][Full Text] [Related]  

  • 6. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR.
    Feldman HC; Ghosh R; Auyeung VC; Mueller JL; Kim JH; Potter ZE; Vidadala VN; Perera BGK; Olivier A; Backes BJ; Zikherman J; Papa FR; Maly DJ
    Nat Chem Biol; 2021 Nov; 17(11):1148-1156. PubMed ID: 34556859
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.
    Wang L; Perera BG; Hari SB; Bhhatarai B; Backes BJ; Seeliger MA; Schürer SC; Oakes SA; Papa FR; Maly DJ
    Nat Chem Biol; 2012 Dec; 8(12):982-9. PubMed ID: 23086298
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1α Kinase-Endoribonuclease.
    Colombano G; Caldwell JJ; Matthews TP; Bhatia C; Joshi A; McHardy T; Mok NY; Newbatt Y; Pickard L; Strover J; Hedayat S; Walton MI; Myers SM; Jones AM; Saville H; McAndrew C; Burke R; Eccles SA; Davies FE; Bayliss R; Collins I
    J Med Chem; 2019 Mar; 62(5):2447-2465. PubMed ID: 30779566
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of a Chemical Toolset for Studying the Paralog-Specific Function of IRE1.
    Feldman HC; Vidadala VN; Potter ZE; Papa FR; Backes BJ; Maly DJ
    ACS Chem Biol; 2019 Dec; 14(12):2595-2605. PubMed ID: 31609569
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Clustering of IRE1α depends on sensing ER stress but not on its RNase activity.
    Ricci D; Marrocco I; Blumenthal D; Dibos M; Eletto D; Vargas J; Boyle S; Iwamoto Y; Chomistek S; Paton JC; Paton AW; Argon Y
    FASEB J; 2019 Sep; 33(9):9811-9827. PubMed ID: 31199681
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α.
    Itzhak D; Bright M; McAndrew P; Mirza A; Newbatt Y; Strover J; Widya M; Thompson A; Morgan G; Collins I; Davies F
    BMC Biochem; 2014 Feb; 15():3. PubMed ID: 24524643
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.
    Newbatt Y; Hardcastle A; McAndrew PC; Strover JA; Mirza A; Morgan GJ; Burke R; Davies FE; Collins I; van Montfort RL
    J Biomol Screen; 2013 Mar; 18(3):298-308. PubMed ID: 23139381
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular mechanisms of human IRE1 activation through dimerization and ligand binding.
    Joshi A; Newbatt Y; McAndrew PC; Stubbs M; Burke R; Richards MW; Bhatia C; Caldwell JJ; McHardy T; Collins I; Bayliss R
    Oncotarget; 2015 May; 6(15):13019-35. PubMed ID: 25968568
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.
    Han D; Upton JP; Hagen A; Callahan J; Oakes SA; Papa FR
    Biochem Biophys Res Commun; 2008 Jan; 365(4):777-83. PubMed ID: 18035051
    [TBL] [Abstract][Full Text] [Related]  

  • 15. An interdomain helix in IRE1α mediates the conformational change required for the sensor's activation.
    Ricci D; Tutton S; Marrocco I; Ying M; Blumenthal D; Eletto D; Vargas J; Boyle S; Fazelinia H; Qian L; Suresh K; Taylor D; Paton JC; Paton AW; Tang CA; Hu CA; Radhakrishnan R; Gidalevitz T; Argon Y
    J Biol Chem; 2021; 296():100781. PubMed ID: 34000298
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Opposite Roles of RNase and Kinase Activities of Inositol-Requiring Enzyme 1 (IRE1) on HSV-1 Replication.
    Su A; Wang H; Li Y; Wang X; Chen D; Wu Z
    Viruses; 2017 Aug; 9(9):. PubMed ID: 28832521
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Pharmacological Targeting of IRE1 in Cancer.
    Raymundo DP; Doultsinos D; Guillory X; Carlesso A; Eriksson LA; Chevet E
    Trends Cancer; 2020 Dec; 6(12):1018-1030. PubMed ID: 32861679
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung.
    Thamsen M; Ghosh R; Auyeung VC; Brumwell A; Chapman HA; Backes BJ; Perara G; Maly DJ; Sheppard D; Papa FR
    PLoS One; 2019; 14(1):e0209824. PubMed ID: 30625178
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.
    Ali MM; Bagratuni T; Davenport EL; Nowak PR; Silva-Santisteban MC; Hardcastle A; McAndrews C; Rowlands MG; Morgan GJ; Aherne W; Collins I; Davies FE; Pearl LH
    EMBO J; 2011 Mar; 30(5):894-905. PubMed ID: 21317875
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational Modeling.
    Carlesso A; Chintha C; Gorman AM; Samali A; Eriksson LA
    Int J Mol Sci; 2019 Nov; 20(22):. PubMed ID: 31698846
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.