234 related articles for article (PubMed ID: 27244671)
1. The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.
Hoxhaj G; Caddye E; Najafov A; Houde VP; Johnson C; Dissanayake K; Toth R; Campbell DG; Prescott AR; MacKintosh C
Elife; 2016 Apr; 5():. PubMed ID: 27244671
[TBL] [Abstract][Full Text] [Related]
2. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
Zoncu R; Bar-Peled L; Efeyan A; Wang S; Sancak Y; Sabatini DM
Science; 2011 Nov; 334(6056):678-83. PubMed ID: 22053050
[TBL] [Abstract][Full Text] [Related]
3. Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly.
Stransky LA; Forgac M
J Biol Chem; 2015 Nov; 290(45):27360-27369. PubMed ID: 26378229
[TBL] [Abstract][Full Text] [Related]
4. Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.
Jung J; Genau HM; Behrends C
Mol Cell Biol; 2015 Jul; 35(14):2479-94. PubMed ID: 25963655
[TBL] [Abstract][Full Text] [Related]
5. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Bar-Peled L; Schweitzer LD; Zoncu R; Sabatini DM
Cell; 2012 Sep; 150(6):1196-208. PubMed ID: 22980980
[TBL] [Abstract][Full Text] [Related]
6. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.
Ögmundsdóttir MH; Heublein S; Kazi S; Reynolds B; Visvalingam SM; Shaw MK; Goberdhan DC
PLoS One; 2012; 7(5):e36616. PubMed ID: 22574197
[TBL] [Abstract][Full Text] [Related]
7. Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.
Oshiro N; Rapley J; Avruch J
J Biol Chem; 2014 Jan; 289(5):2658-74. PubMed ID: 24337580
[TBL] [Abstract][Full Text] [Related]
8. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Rebsamen M; Pochini L; Stasyk T; de Araújo ME; Galluccio M; Kandasamy RK; Snijder B; Fauster A; Rudashevskaya EL; Bruckner M; Scorzoni S; Filipek PA; Huber KV; Bigenzahn JW; Heinz LX; Kraft C; Bennett KL; Indiveri C; Huber LA; Superti-Furga G
Nature; 2015 Mar; 519(7544):477-81. PubMed ID: 25561175
[TBL] [Abstract][Full Text] [Related]
9. Amino acids and mTORC1: from lysosomes to disease.
Efeyan A; Zoncu R; Sabatini DM
Trends Mol Med; 2012 Sep; 18(9):524-33. PubMed ID: 22749019
[TBL] [Abstract][Full Text] [Related]
10. Rag GTPase in amino acid signaling.
Kim J; Kim E
Amino Acids; 2016 Apr; 48(4):915-928. PubMed ID: 26781224
[TBL] [Abstract][Full Text] [Related]
11. Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.
Schweitzer LD; Comb WC; Bar-Peled L; Sabatini DM
Cell Rep; 2015 Sep; 12(9):1445-55. PubMed ID: 26299971
[TBL] [Abstract][Full Text] [Related]
12. Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway.
Wang Z; Liu S; Kakizaki M; Hirose Y; Ishikawa Y; Funato H; Yanagisawa M; Yu Y; Liu Q
J Biol Chem; 2014 Nov; 289(46):31950-31959. PubMed ID: 25278019
[TBL] [Abstract][Full Text] [Related]
13. Amino acid signalling upstream of mTOR.
Jewell JL; Russell RC; Guan KL
Nat Rev Mol Cell Biol; 2013 Mar; 14(3):133-9. PubMed ID: 23361334
[TBL] [Abstract][Full Text] [Related]
14. Regulation of mTORC1 by amino acids.
Bar-Peled L; Sabatini DM
Trends Cell Biol; 2014 Jul; 24(7):400-6. PubMed ID: 24698685
[TBL] [Abstract][Full Text] [Related]
15. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Sancak Y; Bar-Peled L; Zoncu R; Markhard AL; Nada S; Sabatini DM
Cell; 2010 Apr; 141(2):290-303. PubMed ID: 20381137
[TBL] [Abstract][Full Text] [Related]
16. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.
Efeyan A; Zoncu R; Chang S; Gumper I; Snitkin H; Wolfson RL; Kirak O; Sabatini DD; Sabatini DM
Nature; 2013 Jan; 493(7434):679-83. PubMed ID: 23263183
[TBL] [Abstract][Full Text] [Related]
17. Dynamics of mTORC1 activation in response to amino acids.
Manifava M; Smith M; Rotondo S; Walker S; Niewczas I; Zoncu R; Clark J; Ktistakis NT
Elife; 2016 Oct; 5():. PubMed ID: 27725083
[TBL] [Abstract][Full Text] [Related]
18. Metabolism. Differential regulation of mTORC1 by leucine and glutamine.
Jewell JL; Kim YC; Russell RC; Yu FX; Park HW; Plouffe SW; Tagliabracci VS; Guan KL
Science; 2015 Jan; 347(6218):194-8. PubMed ID: 25567907
[TBL] [Abstract][Full Text] [Related]
19. Pharmacological inhibition of lysosomes activates the MTORC1 signaling pathway in chondrocytes in an autophagy-independent manner.
Newton PT; Vuppalapati KK; Bouderlique T; Chagin AS
Autophagy; 2015; 11(9):1594-607. PubMed ID: 26259639
[TBL] [Abstract][Full Text] [Related]
20. LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.
Milkereit R; Persaud A; Vanoaica L; Guetg A; Verrey F; Rotin D
Nat Commun; 2015 May; 6():7250. PubMed ID: 25998567
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]