137 related articles for article (PubMed ID: 27248988)
1. Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration.
Xu X; Zhao X; Yang Z; Wang H; Meng X; Su C; Liu M; Fawcett JP; Yang Y; Gu J
Molecules; 2016 May; 21(6):. PubMed ID: 27248988
[TBL] [Abstract][Full Text] [Related]
2. Overcoming clopidogrel resistance: discovery of vicagrel as a highly potent and orally bioavailable antiplatelet agent.
Shan J; Zhang B; Zhu Y; Jiao B; Zheng W; Qi X; Gong Y; Yuan F; Lv F; Sun H
J Med Chem; 2012 Apr; 55(7):3342-52. PubMed ID: 22428882
[TBL] [Abstract][Full Text] [Related]
3. Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma.
Liu C; Lu Y; Sun H; Yang J; Liu Y; Lai X; Gong Y; Liu X; Li Y; Zhang Y; Chen X; Zhong D
J Pharm Biomed Anal; 2018 Feb; 149():394-402. PubMed ID: 29154109
[TBL] [Abstract][Full Text] [Related]
4. Pharmacokinetics of vicagrel, a promising analog of clopidogrel, in rats and beagle dogs.
Qiu Z; Li N; Wang X; Tian F; Liu Q; Song L; Fan Z; Lu Y; Chen X
J Pharm Sci; 2013 Feb; 102(2):741-9. PubMed ID: 23192851
[TBL] [Abstract][Full Text] [Related]
5. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y
Liu C; Zhang Y; Chen W; Lu Y; Li W; Liu Y; Lai X; Gong Y; Liu X; Li Y; Chen X; Li X; Sun H; Yang J; Zhong D
Eur J Pharm Sci; 2019 Jan; 127():151-160. PubMed ID: 30326264
[TBL] [Abstract][Full Text] [Related]
6. Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation.
Jia YM; Ge PX; Zhou H; Ji JZ; Tai T; Gu TT; Zhu T; Li YF; Mi QY; Huang BB; Xie HG
Biomed Pharmacother; 2019 Jul; 115():108906. PubMed ID: 31060007
[TBL] [Abstract][Full Text] [Related]
7. Aspirin Attenuates the Bioactivation of and Platelet Response to Vicagrel in Mice.
Jia YM; Gu TT; Ji JZ; Tai T; Zhang MR; Huang BB; Zhou H; Mi QY; Xie HG
J Cardiovasc Pharmacol; 2018 Nov; 72(5):252-258. PubMed ID: 30358688
[TBL] [Abstract][Full Text] [Related]
8. Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel.
Qiu Z; Li N; Song L; Lu Y; Jing J; Parekha HS; Gao W; Tian F; Wang X; Ren S; Chen X
Pharm Res; 2014 Jan; 31(1):238-51. PubMed ID: 24037619
[TBL] [Abstract][Full Text] [Related]
9. Overcoming Clopidogrel Resistance: Three Promising Novel Antiplatelet Drugs Developed in China.
Xie HG; Jia YM; Tai T; Ji JZ
J Cardiovasc Pharmacol; 2017 Dec; 70(6):356-361. PubMed ID: 28817486
[TBL] [Abstract][Full Text] [Related]
10. Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel.
Payne CD; Li YG; Small DS; Ernest CS; Farid NA; Jakubowski JA; Brandt JT; Salazar DE; Winters KJ
J Cardiovasc Pharmacol; 2007 Nov; 50(5):555-62. PubMed ID: 18030066
[TBL] [Abstract][Full Text] [Related]
11. Platelet inhibitory activity, tolerability, and safety of vicagrel, a novel thienopyridine P2Y12 inhibitor.
Li H; Chen H; Chen W; Xu H; Yuan F; Yang M; Sun H; Yang J; Liu Y; Lai X; Gong Y; Liu X; Li Y; Sheng L; Liu C; Li X
Medicine (Baltimore); 2020 Jan; 99(4):e18683. PubMed ID: 31977858
[TBL] [Abstract][Full Text] [Related]
12. Impacts of CYP2C19 genetic polymorphisms on bioavailability and effect on platelet adhesion of vicagrel, a novel thienopyridine P2Y
Zhang Y; Zhu X; Zhan Y; Li X; Liu C; Zhu Y; Zhang H; Wei H; Xia Y; Sun H; Liu Y; Lai X; Gong Y; Liu X; Li Y; Ding Y; Zhong D
Br J Clin Pharmacol; 2020 Sep; 86(9):1860-1874. PubMed ID: 32267573
[TBL] [Abstract][Full Text] [Related]
13. Enhanced responsiveness of platelets to vicagrel in IL-10-deficient mice through STAT3-dependent up-regulation of the hydrolase arylacetamide deacetylase in the intestine.
Jia YM; Zhou H; Tai T; Gu TT; Ji JZ; Mi QY; Huang BB; Li YF; Zhu T; Xie HG
Br J Pharmacol; 2019 Jun; 176(11):1717-1727. PubMed ID: 30825385
[TBL] [Abstract][Full Text] [Related]
14. Bioequivalence and tolerability of two clopidogrel salt preparations, besylate and bisulfate: a randomized, open-label, crossover study in healthy Korean male subjects.
Kim SD; Kang W; Lee HW; Park DJ; Ahn JH; Kim MJ; Kim EY; Kim SW; Nam HS; Na HJ; Yoon YR
Clin Ther; 2009 Apr; 31(4):793-803. PubMed ID: 19446152
[TBL] [Abstract][Full Text] [Related]
15. Comparison of formation of thiolactones and active metabolites of prasugrel and clopidogrel in rats and dogs.
Hagihara K; Kazui M; Ikenaga H; Nanba T; Fusegawa K; Takahashi M; Kurihara A; Okazaki O; Farid NA; Ikeda T
Xenobiotica; 2009 Mar; 39(3):218-26. PubMed ID: 19280520
[TBL] [Abstract][Full Text] [Related]
16. Semi-mechanistic population pharmacokinetics analysis reveals distinct CYP2C19 dependency in the bioactivation of vicagrel and clopidogrel to active metabolite M15-2.
Zhang L; Sun H; Liu Y; Lai X; Gong Y; Liu X; Li YG; He Y; Zhang EY; Yan X
Eur J Pharm Sci; 2022 Oct; 177():106264. PubMed ID: 35868434
[TBL] [Abstract][Full Text] [Related]
17. Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans.
Farid NA; Kurihara A; Wrighton SA
J Clin Pharmacol; 2010 Feb; 50(2):126-42. PubMed ID: 19948947
[TBL] [Abstract][Full Text] [Related]
18. Differential inhibitory effects of proton pump inhibitors on the metabolism and antiplatelet activities of clopidogrel and prasugrel.
Chen CH; Yang JC; Uang YS; Lin CJ
Biopharm Drug Dispos; 2012 Jul; 33(5):278-83. PubMed ID: 22623337
[TBL] [Abstract][Full Text] [Related]
19. P2Y12, a new platelet ADP receptor, target of clopidogrel.
Herbert JM; Savi P
Semin Vasc Med; 2003 May; 3(2):113-22. PubMed ID: 15199474
[TBL] [Abstract][Full Text] [Related]
20. Development and validation of a UPLC-MS/MS method for simultaneous determination of vicagrel and its major metabolites in rat or human plasma: An optimized novel strategy for the stabilization of vicagrel.
Tai T; Zhou H; Zhu T; Jia YM; Ji JZ; Li YF; Mi QY; Xie HG
J Pharm Biomed Anal; 2020 Feb; 179():112955. PubMed ID: 31866139
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
