227 related articles for article (PubMed ID: 27291296)
1. Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor.
Goldgof GM; Durrant JD; Ottilie S; Vigil E; Allen KE; Gunawan F; Kostylev M; Henderson KA; Yang J; Schenken J; LaMonte GM; Manary MJ; Murao A; Nachon M; Murray R; Prescott M; McNamara CW; Slayman CW; Amaro RE; Suzuki Y; Winzeler EA
Sci Rep; 2016 Jun; 6():27806. PubMed ID: 27291296
[TBL] [Abstract][Full Text] [Related]
2. Spiroindolone NITD609 is a novel antimalarial drug that targets the P-type ATPase PfATP4.
Turner H
Future Med Chem; 2016; 8(2):227-38. PubMed ID: 26824174
[TBL] [Abstract][Full Text] [Related]
3. The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs.
Spillman NJ; Kirk K
Int J Parasitol Drugs Drug Resist; 2015 Dec; 5(3):149-62. PubMed ID: 26401486
[TBL] [Abstract][Full Text] [Related]
4. Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials.
Spillman NJ; Allen RJ; McNamara CW; Yeung BK; Winzeler EA; Diagana TT; Kirk K
Cell Host Microbe; 2013 Feb; 13(2):227-37. PubMed ID: 23414762
[TBL] [Abstract][Full Text] [Related]
5. Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials.
Dennis ASM; Lehane AM; Ridgway MC; Holleran JP; Kirk K
Antimicrob Agents Chemother; 2018 Jun; 62(6):. PubMed ID: 29555632
[TBL] [Abstract][Full Text] [Related]
6. Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials.
Flannery EL; McNamara CW; Kim SW; Kato TS; Li F; Teng CH; Gagaring K; Manary MJ; Barboa R; Meister S; Kuhen K; Vinetz JM; Chatterjee AK; Winzeler EA
ACS Chem Biol; 2015 Feb; 10(2):413-20. PubMed ID: 25322084
[TBL] [Abstract][Full Text] [Related]
7. Biochemical characterization and chemical inhibition of PfATP4-associated Na
Rosling JEO; Ridgway MC; Summers RL; Kirk K; Lehane AM
J Biol Chem; 2018 Aug; 293(34):13327-13337. PubMed ID: 29986883
[TBL] [Abstract][Full Text] [Related]
8. A Basis for Rapid Clearance of Circulating Ring-Stage Malaria Parasites by the Spiroindolone KAE609.
Zhang R; Suwanarusk R; Malleret B; Cooke BM; Nosten F; Lau YL; Dao M; Lim CT; Renia L; Tan KS; Russell B
J Infect Dis; 2016 Jan; 213(1):100-4. PubMed ID: 26136472
[TBL] [Abstract][Full Text] [Related]
9. The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound.
Bouwman SA; Zoleko-Manego R; Renner KC; Schmitt EK; Mombo-Ngoma G; Grobusch MP
Travel Med Infect Dis; 2020; 36():101765. PubMed ID: 32561392
[TBL] [Abstract][Full Text] [Related]
10. The Spiroindolone KAE609 Does Not Induce Dormant Ring Stages in Plasmodium falciparum Parasites.
Chavchich M; Van Breda K; Rowcliffe K; Diagana TT; Edstein MD
Antimicrob Agents Chemother; 2016 Sep; 60(9):5167-74. PubMed ID: 27297484
[TBL] [Abstract][Full Text] [Related]
11. Spiroindolones, a potent compound class for the treatment of malaria.
Rottmann M; McNamara C; Yeung BK; Lee MC; Zou B; Russell B; Seitz P; Plouffe DM; Dharia NV; Tan J; Cohen SB; Spencer KR; González-Páez GE; Lakshminarayana SB; Goh A; Suwanarusk R; Jegla T; Schmitt EK; Beck HP; Brun R; Nosten F; Renia L; Dartois V; Keller TH; Fidock DA; Winzeler EA; Diagana TT
Science; 2010 Sep; 329(5996):1175-80. PubMed ID: 20813948
[TBL] [Abstract][Full Text] [Related]
12. KBE009: An antimalarial bestatin-like inhibitor of the Plasmodium falciparum M1 aminopeptidase discovered in an Ugi multicomponent reaction-derived peptidomimetic library.
González-Bacerio J; Maluf SEC; Méndez Y; Pascual I; Florent I; Melo PMS; Budu A; Ferreira JC; Moreno E; Carmona AK; Rivera DG; Alonso Del Rivero M; Gazarini ML
Bioorg Med Chem; 2017 Sep; 25(17):4628-4636. PubMed ID: 28728898
[TBL] [Abstract][Full Text] [Related]
13. Search for novel
Reghunandanan K; T P A; Krishnan N; K M D; Prasad R; Nelson-Sathi S; Chandramohanadas R
J Biomol Struct Dyn; 2024 Aug; 42(12):6200-6211. PubMed ID: 37424150
[TBL] [Abstract][Full Text] [Related]
14. Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites.
Frame IJ; Deniskin R; Rinderspacher A; Katz F; Deng SX; Moir RD; Adjalley SH; Coburn-Flynn O; Fidock DA; Willis IM; Landry DW; Akabas MH
ACS Chem Biol; 2015 Mar; 10(3):775-83. PubMed ID: 25602169
[TBL] [Abstract][Full Text] [Related]
15. Diverse chemotypes disrupt ion homeostasis in the Malaria parasite.
Lehane AM; Ridgway MC; Baker E; Kirk K
Mol Microbiol; 2014 Oct; 94(2):327-39. PubMed ID: 25145582
[TBL] [Abstract][Full Text] [Related]
16. Stereoselective Total Synthesis of KAE609 via Direct Catalytic Asymmetric Alkynylation to Ketimine.
Takada H; Kumagai N; Shibasaki M
Org Lett; 2015 Oct; 17(19):4762-5. PubMed ID: 26367505
[TBL] [Abstract][Full Text] [Related]
17. Metabolic responses in blood-stage malaria parasites associated with increased and decreased sensitivity to PfATP4 inhibitors.
Tewari SG; Elahi R; Kwan B; Rajaram K; Bhatnagar S; Reifman J; Prigge ST; Vaidya AB; Wallqvist A
Malar J; 2023 Feb; 22(1):56. PubMed ID: 36788578
[TBL] [Abstract][Full Text] [Related]
18. Efficacy of Cipargamin (KAE609) in a Randomized, Phase II Dose-Escalation Study in Adults in Sub-Saharan Africa With Uncomplicated Plasmodium falciparum Malaria.
Schmitt EK; Ndayisaba G; Yeka A; Asante KP; Grobusch MP; Karita E; Mugerwa H; Asiimwe S; Oduro A; Fofana B; Doumbia S; Su G; Csermak Renner K; Venishetty VK; Sayyed S; Straimer J; Demin I; Barsainya S; Boulton C; Gandhi P
Clin Infect Dis; 2022 May; 74(10):1831-1839. PubMed ID: 34410358
[TBL] [Abstract][Full Text] [Related]
19. Reconstructing the Qo site of Plasmodium falciparum bc 1 complex in the yeast enzyme.
Vallières C; Fisher N; Meunier B
PLoS One; 2013; 8(8):e71726. PubMed ID: 23951230
[TBL] [Abstract][Full Text] [Related]
20. QSAR, docking and ADMET studies of artemisinin derivatives for antimalarial activity targeting plasmepsin II, a hemoglobin-degrading enzyme from P. falciparum.
Qidwai T; Yadav DK; Khan F; Dhawan S; Bhakuni RS
Curr Pharm Des; 2012; 18(37):6133-54. PubMed ID: 22670592
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]