301 related articles for article (PubMed ID: 27297692)
1. GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism.
Averous J; Lambert-Langlais S; Mesclon F; Carraro V; Parry L; Jousse C; Bruhat A; Maurin AC; Pierre P; Proud CG; Fafournoux P
Sci Rep; 2016 Jun; 6():27698. PubMed ID: 27297692
[TBL] [Abstract][Full Text] [Related]
2. Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver.
Nikonorova IA; Mirek ET; Signore CC; Goudie MP; Wek RC; Anthony TG
J Biol Chem; 2018 Apr; 293(14):5005-5015. PubMed ID: 29449374
[TBL] [Abstract][Full Text] [Related]
3. GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells.
Mazor KM; Stipanuk MH
Amino Acids; 2016 Dec; 48(12):2831-2842. PubMed ID: 27613409
[TBL] [Abstract][Full Text] [Related]
4. A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling.
Brüggenthies JB; Fiore A; Russier M; Bitsina C; Brötzmann J; Kordes S; Menninger S; Wolf A; Conti E; Eickhoff JE; Murray PJ
J Biol Chem; 2022 Dec; 298(12):102629. PubMed ID: 36273589
[TBL] [Abstract][Full Text] [Related]
5. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
Ye J; Palm W; Peng M; King B; Lindsten T; Li MO; Koumenis C; Thompson CB
Genes Dev; 2015 Nov; 29(22):2331-6. PubMed ID: 26543160
[TBL] [Abstract][Full Text] [Related]
6. Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.
Al-Baghdadi RJT; Nikonorova IA; Mirek ET; Wang Y; Park J; Belden WJ; Wek RC; Anthony TG
Sci Rep; 2017 Apr; 7(1):1272. PubMed ID: 28455513
[TBL] [Abstract][Full Text] [Related]
7. Phosphorylation of eIF2α triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma.
Wengrod J; Wang D; Weiss S; Zhong H; Osman I; Gardner LB
Sci Signal; 2015 Mar; 8(367):ra27. PubMed ID: 25759478
[TBL] [Abstract][Full Text] [Related]
8. mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4.
Park Y; Reyna-Neyra A; Philippe L; Thoreen CC
Cell Rep; 2017 May; 19(6):1083-1090. PubMed ID: 28494858
[TBL] [Abstract][Full Text] [Related]
9. ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation.
Xu D; Dai W; Kutzler L; Lacko HA; Jefferson LS; Dennis MD; Kimball SR
J Nutr; 2020 May; 150(5):1022-1030. PubMed ID: 31875479
[TBL] [Abstract][Full Text] [Related]
10. The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
Farooq Z; Kusuma F; Burke P; Dufour CR; Lee D; Tabatabaei N; Toboz P; Radovani E; Greenblatt JF; Rehman J; Class J; Khoutorsky A; Fonseca BD; Richner JM; Mercier E; Bourque G; Giguère V; Subramaniam AR; Han J; Tahmasebi S
J Biol Chem; 2022 Sep; 298(9):102277. PubMed ID: 35863436
[TBL] [Abstract][Full Text] [Related]
11. Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.
Silva RC; Sattlegger E; Castilho BA
J Cell Sci; 2016 Dec; 129(24):4521-4533. PubMed ID: 27852836
[TBL] [Abstract][Full Text] [Related]
12. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.
Nikonorova IA; Al-Baghdadi RJT; Mirek ET; Wang Y; Goudie MP; Wetstein BB; Dixon JL; Hine C; Mitchell JR; Adams CM; Wek RC; Anthony TG
J Biol Chem; 2017 Apr; 292(16):6786-6798. PubMed ID: 28242759
[TBL] [Abstract][Full Text] [Related]
13. Resistance exercise enhances long-term mTORC1 sensitivity to leucine.
D'Hulst G; Masschelein E; De Bock K
Mol Metab; 2022 Dec; 66():101615. PubMed ID: 36252815
[TBL] [Abstract][Full Text] [Related]
14. GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress.
Kato Y; Kunimasa K; Takahashi M; Harada A; Nagasawa I; Osawa M; Sugimoto Y; Tomida A
Mol Pharmacol; 2020 Dec; 98(6):669-676. PubMed ID: 33033108
[TBL] [Abstract][Full Text] [Related]
15. The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.
Guo F; Cavener DR
Cell Metab; 2007 Feb; 5(2):103-14. PubMed ID: 17276353
[TBL] [Abstract][Full Text] [Related]
16. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.
Zhang P; McGrath BC; Reinert J; Olsen DS; Lei L; Gill S; Wek SA; Vattem KM; Wek RC; Kimball SR; Jefferson LS; Cavener DR
Mol Cell Biol; 2002 Oct; 22(19):6681-8. PubMed ID: 12215525
[TBL] [Abstract][Full Text] [Related]
17. Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells.
Darnell AM; Subramaniam AR; O'Shea EK
Mol Cell; 2018 Jul; 71(2):229-243.e11. PubMed ID: 30029003
[TBL] [Abstract][Full Text] [Related]
18. The Gcn2-eIF2α pathway connects iron and amino acid homeostasis in
Caballero-Molada M; Planes MD; Benlloch H; Atares S; Naranjo MA; Serrano R
Biochem J; 2018 Apr; 475(8):1523-1534. PubMed ID: 29626156
[TBL] [Abstract][Full Text] [Related]
19. Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway.
Carraro V; Maurin AC; Lambert-Langlais S; Averous J; Chaveroux C; Parry L; Jousse C; Ord D; Ord T; Fafournoux P; Bruhat A
PLoS One; 2010 Dec; 5(12):e15716. PubMed ID: 21203563
[TBL] [Abstract][Full Text] [Related]
20. Genetic removal of eIF2α kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity.
Zimmermann HR; Yang W; Beckelman BC; Kasica NP; Zhou X; Galli LD; Ryazanov AG; Ma T
J Neurochem; 2018 Jul; 146(2):133-144. PubMed ID: 29337352
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
