159 related articles for article (PubMed ID: 2730570)
1. A 13C-n.m.r. investigation of the ionizations within an inhibitor--alpha-chymotrypsin complex. Evidence that both alpha-chymotrypsin and trypsin stabilize a hemiketal oxyanion by similar mechanisms.
Finucane MD; Hudson EA; Malthouse JP
Biochem J; 1989 Mar; 258(3):853-9. PubMed ID: 2730570
[TBL] [Abstract][Full Text] [Related]
2. A study of the stabilization of tetrahedral adducts by trypsin and delta-chymotrypsin.
Finucane MD; Malthouse JP
Biochem J; 1992 Sep; 286 ( Pt 3)(Pt 3):889-900. PubMed ID: 1417749
[TBL] [Abstract][Full Text] [Related]
3. A 13C-n.m.r. investigation of ionizations within a trypsin-inhibitor complex. Evidence that the pKa of histidine-57 is raised by interaction with the hemiketal oxyanion.
Primrose WU; Scott AI; Mackenzie NE; Malthouse JP
Biochem J; 1985 Nov; 231(3):677-82. PubMed ID: 4074329
[TBL] [Abstract][Full Text] [Related]
4. 13C NMR study of the ionizations within a trypsin-chloromethyl ketone inhibitor complex.
Malthouse JP; Primrose WU; Mackenzie NE; Scott AI
Biochemistry; 1985 Jul; 24(14):3478-87. PubMed ID: 4041423
[TBL] [Abstract][Full Text] [Related]
5. A study of the stabilization of the oxyanion of tetrahedral adducts by trypsin, chymotrypsin and subtilisin.
O'Connell TP; Malthouse JP
Biochem J; 1995 Apr; 307 ( Pt 2)(Pt 2):353-9. PubMed ID: 7733869
[TBL] [Abstract][Full Text] [Related]
6. Determination of the ionization state of the active-site histidine in a subtilisin-(chloromethane inhibitor) derivative by 13C-NMR.
O'Connell TP; Malthouse JP
Biochem J; 1996 Jul; 317 ( Pt 1)(Pt 1):35-40. PubMed ID: 8694783
[TBL] [Abstract][Full Text] [Related]
7. 15N and 1H NMR spectroscopy of the catalytic histidine in chloromethyl ketone-inhibited complexes of serine proteases.
Tsilikounas E; Rao T; Gutheil WG; Bachovchin WW
Biochemistry; 1996 Feb; 35(7):2437-44. PubMed ID: 8652587
[TBL] [Abstract][Full Text] [Related]
8. A 13C-NMR study of the role of Asn-155 in stabilizing the oxyanion of a subtilisin tetrahedral adduct.
O'connell TP; Day RM; Torchilin EV; Bachovchin WW; Malthouse JG
Biochem J; 1997 Sep; 326 ( Pt 3)(Pt 3):861-6. PubMed ID: 9307038
[TBL] [Abstract][Full Text] [Related]
9. 13C-NMR study of the inhibition of delta-chymotrypsin by a tripeptide-glyoxal inhibitor.
Djurdjevic-Pahl A; Hewage C; Malthouse JP
Biochem J; 2002 Mar; 362(Pt 2):339-47. PubMed ID: 11853541
[TBL] [Abstract][Full Text] [Related]
10. 13C and 1H NMR studies of ionizations and hydrogen bonding in chymotrypsin-glyoxal inhibitor complexes.
Spink E; Cosgrove S; Rogers L; Hewage C; Malthouse JP
J Biol Chem; 2007 Mar; 282(11):7852-61. PubMed ID: 17213185
[TBL] [Abstract][Full Text] [Related]
11. A study of the relaxation parameters of a 13C-enriched methylene carbon and a 13C-enriched perdeuteromethylene carbon attached to chymotrypsin.
Malthouse JP; Finucane MD
Biochem J; 1991 Dec; 280 ( Pt 3)(Pt 3):649-57. PubMed ID: 1764028
[TBL] [Abstract][Full Text] [Related]
12. 13C NMR study of how the oxyanion pKa values of subtilisin and chymotrypsin tetrahedral adducts are affected by different amino acid residues binding in enzyme subsites S1-S4.
O'Sullivan DB; O'Connell TP; Mahon MM; Koenig A; Milne JJ; Fitzpatrick TB; Malthouse JP
Biochemistry; 1999 May; 38(19):6187-94. PubMed ID: 10320347
[TBL] [Abstract][Full Text] [Related]
13. Complex of alpha-chymotrypsin and N-acetyl-L-leucyl-L-phenylalanyl trifluoromethyl ketone: structural studies with NMR spectroscopy.
Liang TC; Abeles RH
Biochemistry; 1987 Dec; 26(24):7603-8. PubMed ID: 3427096
[TBL] [Abstract][Full Text] [Related]
14. Chloroketone hydrolysis by chymotrypsin and N-methylhistidyl-57-chymotrypsin: implications for the mechanism of chymotrypsin inactivation by chloroketones.
Prorok M; Albeck A; Foxman BM; Abeles RH
Biochemistry; 1994 Aug; 33(32):9784-90. PubMed ID: 8068658
[TBL] [Abstract][Full Text] [Related]
15. Zymogen activation in serine proteinases. Proton magnetic resonance pH titration studies of the two histidines of bovine chymotrypsinogen A and chymotrypsin Aalpha.
Markley JL; Ibañez IB
Biochemistry; 1978 Oct; 17(22):4627-40. PubMed ID: 31898
[TBL] [Abstract][Full Text] [Related]
16. Properties of the His57-Asp102 dyad of rat trypsin D189S in the zymogen, activated enzyme, and alpha1-proteinase inhibitor complexed forms.
Kaslik G; Westler WM; Gráf L; Markley JL
Arch Biochem Biophys; 1999 Feb; 362(2):254-64. PubMed ID: 9989934
[TBL] [Abstract][Full Text] [Related]
17. Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin.
Neidhart D; Wei Y; Cassidy C; Lin J; Cleland WW; Frey PA
Biochemistry; 2001 Feb; 40(8):2439-47. PubMed ID: 11327865
[TBL] [Abstract][Full Text] [Related]
18. Enzymic and physicochemical properties of Streptomyces griseus trypsin.
Olafson RW; Smillie LB
Biochemistry; 1975 Mar; 14(6):1161-7. PubMed ID: 235280
[TBL] [Abstract][Full Text] [Related]
19. Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor.
Mac Sweeney A; Birrane G; Walsh MA; O'Connell T; Malthouse JP; Higgins TM
Acta Crystallogr D Biol Crystallogr; 2000 Mar; 56(Pt 3):280-6. PubMed ID: 10713514
[TBL] [Abstract][Full Text] [Related]
20. Correlations of the basicity of His 57 with transition state analogue binding, substrate reactivity, and the strength of the low-barrier hydrogen bond in chymotrypsin.
Lin J; Cassidy CS; Frey PA
Biochemistry; 1998 Aug; 37(34):11940-8. PubMed ID: 9718318
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]